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Series GSE161124 Query DataSets for GSE161124
Status Public on Nov 10, 2020
Title Expression Data from Young Uteroplacental Insufficiency-induced Low Birth Weight Adult Guinea Pig Offspring
Organism Cavia porcellus
Experiment type Expression profiling by array
Summary We aimed to gain mechanistic insights into the impact of uteroplacental insufficiency upon hepatic cholestrol metabolism pathways in young adult offspring.Uterine artery ablation-induced low birth weight (LBW) and normal birth weight (NBW) male and female guinea pig offspring were fed a control diet from weaning until postnatal day 150.
Analysis of whole hepatic transcriptome results identified that between LBW and NBW offspring livers, 51 (29 up-regulated and 22 down-regulated) and 31 (8 up-regulated and 23 down-regulated) genes were differentially expressed in males and females respectively (fold change| >= 2 and p-value < 0.05). KEGG pathway analysis of these differentially expressed genes revealed that “Cholesterol metabolism” was an enriched pathway in LBW males but not females (p<0.05).
 
Overall design A whole-Transcript Expression Analysis Gene Titan was conducted (Genome Québec Innovation Centre, QU, Canada) on guinea pig livers of 5 NBW males, 5 LBW males, 5 NBW females and 5 LBW females.
 
Contributor(s) Sarr O, Mathers KE, Vanderboor C, Devgan A, Hardy DB, Zhao L, Regnault TR
Citation(s) 34230622
Submission date Nov 09, 2020
Last update date Dec 01, 2021
Contact name Ousseynou Sarr
E-mail(s) osarr@uwo.ca
Phone 2262685936
Organization name Western universitry
Department Physiology & Pharmacology
Street address 1811 Creekside Street
City London
State/province United States
ZIP/Postal code N5X4L8
Country Canada
 
Platforms (1)
GPL29378 [GuiGene-1_1-st] Affymetrix Guinea Pig Gene 1.1 ST Array [transcript (gene) version]
Samples (20)
GSM4889900 NBW male liver, biological rep1
GSM4889901 NBW male liver, biological rep2
GSM4889902 NBW male liver, biological rep3
Relations
BioProject PRJNA675617

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE161124_RAW.tar 86.4 Mb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file

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