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Status |
Public on Nov 10, 2020 |
Title |
Expression Data from Young Uteroplacental Insufficiency-induced Low Birth Weight Adult Guinea Pig Offspring |
Organism |
Cavia porcellus |
Experiment type |
Expression profiling by array
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Summary |
We aimed to gain mechanistic insights into the impact of uteroplacental insufficiency upon hepatic cholestrol metabolism pathways in young adult offspring.Uterine artery ablation-induced low birth weight (LBW) and normal birth weight (NBW) male and female guinea pig offspring were fed a control diet from weaning until postnatal day 150. Analysis of whole hepatic transcriptome results identified that between LBW and NBW offspring livers, 51 (29 up-regulated and 22 down-regulated) and 31 (8 up-regulated and 23 down-regulated) genes were differentially expressed in males and females respectively (fold change| >= 2 and p-value < 0.05). KEGG pathway analysis of these differentially expressed genes revealed that “Cholesterol metabolism” was an enriched pathway in LBW males but not females (p<0.05).
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Overall design |
A whole-Transcript Expression Analysis Gene Titan was conducted (Genome Québec Innovation Centre, QU, Canada) on guinea pig livers of 5 NBW males, 5 LBW males, 5 NBW females and 5 LBW females.
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Contributor(s) |
Sarr O, Mathers KE, Vanderboor C, Devgan A, Hardy DB, Zhao L, Regnault TR |
Citation(s) |
34230622 |
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Submission date |
Nov 09, 2020 |
Last update date |
Dec 01, 2021 |
Contact name |
Ousseynou Sarr |
E-mail(s) |
osarr@uwo.ca
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Phone |
2262685936
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Organization name |
Western universitry
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Department |
Physiology & Pharmacology
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Street address |
1811 Creekside Street
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City |
London |
State/province |
United States |
ZIP/Postal code |
N5X4L8 |
Country |
Canada |
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Platforms (1) |
GPL29378 |
[GuiGene-1_1-st] Affymetrix Guinea Pig Gene 1.1 ST Array [transcript (gene) version] |
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Samples (20)
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GSM4889903 |
NBW male liver, biological rep4 |
GSM4889904 |
NBW male liver, biological rep5 |
GSM4889905 |
LBW male liver, biological rep1 |
GSM4889906 |
LBW male liver, biological rep2 |
GSM4889907 |
LBW male liver, biological rep3 |
GSM4889908 |
LBW male liver, biological rep4 |
GSM4889909 |
LBW male liver, biological rep5 |
GSM4889910 |
NBW female liver, biological rep1 |
GSM4889911 |
NBW female liver, biological rep2 |
GSM4889912 |
NBW female liver, biological rep3 |
GSM4889913 |
NBW female liver, biological rep4 |
GSM4889914 |
NBW female liver, biological rep5 |
GSM4889915 |
LBW female liver, biological rep1 |
GSM4889916 |
LBW female liver, biological rep2 |
GSM4889917 |
LBW female liver, biological rep3 |
GSM4889918 |
LBW female liver, biological rep4 |
GSM4889919 |
LBW female liver, biological rep5 |
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Relations |
BioProject |
PRJNA675617 |
Supplementary file |
Size |
Download |
File type/resource |
GSE161124_RAW.tar |
86.4 Mb |
(http)(custom) |
TAR (of CEL, CHP) |
Processed data included within Sample table |
Processed data provided as supplementary file |
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