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| Status |
Public on Feb 18, 2022 |
| Title |
Olig2 Defines a Unique Subset of Neural Stem Cells That Produce Specific Olfactory Bulb Interneuron Subtypes in the Subventricular Zone of Postnatal and Adult Mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Distinct neural stem cells reside in different regions of the subventricular zone and generate multiple olfactory bulb interneuron subtypes in the adult mouse brain. This study shows that the basic helix-loop-helix type transcription factor Olig2 defines a ventrally enriched subset of NSCs in the early postnatal and adult SVZ and plays an important role in the subtype specification of olfactory bulb interneurons produced by adult NSCs.
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| Overall design |
E18.5, P14 and adult mouse NSCs were analyzed using 10X single-cell rna-seq
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| Contributor(s) |
Adam M, Campbell K, Nakafuku M |
| Citation(s) |
35132995 |
| Submission date |
May 13, 2021 |
| Last update date |
May 20, 2022 |
| Contact name |
Steve Potter |
| Organization name |
Cincinnati Children's Hospital Research Foundation
|
| Department |
Developmental Biology
|
| Street address |
240 Albert Sabin Way
|
| City |
Cincinnati |
| State/province |
Ohio |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA729735 |
| SRA |
SRP319681 |
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