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| Status |
Public on Oct 15, 2004 |
| Title |
Effect of Oxandrolone on Muscle in Duchenne Muscular Dystrophy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Three subjects with Duchenne muscular dystrophy (8.3, 10.4, and 16.7 years old) were studied. Baseline studies included stable isotope infusion followed by gastrocnemius muscle biopsy to determine myosin heavy chain synthesis rates. RNA was isolated from the muscle biopsy as well. The subjects were then treated for 3 months with oxandrolone (a synthetic anabolic steroid, 0.1 mg/kg/day) and the studies repeated.
Keywords = muscle
Keywords = Duschenne muscular dystrophy
Keywords = oxandrolone
Keywords = androgen
Keywords: parallel sample
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| Contributor(s) |
Olney RC, Balagopal P, Darmaun D, Mougey E, Dokler M, Sieck G, Hammond D |
| Citation(s) |
16263771 |
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| Submission date |
Sep 15, 2004 |
| Last update date |
Aug 10, 2018 |
| Contact name |
Robert C. Olney |
| E-mail(s) |
rolney@nemours.org
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| Phone |
904-390-3674
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| Fax |
904-858-3948
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| Organization name |
Nemours Children's Clinic
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| Department |
Pediatrics
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| Lab |
Cellular and Molecular Laboratory
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| Street address |
807 Children's Way
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| City |
Jacksonville |
| State/province |
FL |
| ZIP/Postal code |
32207 |
| Country |
USA |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL97 |
[HG-U133B] Affymetrix Human Genome U133B Array |
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| Samples (12)
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| GSM30669 |
DMD Subject 1, baseline, HU133A |
| GSM30670 |
DMD Subject 2, baseline, HU133A |
| GSM30671 |
DMD Subject 3, baseline, HU133A |
| GSM30672 |
DMD Subject 1, post-oxandrolone, HU133A |
| GSM30673 |
DMD Subject 2, post-oxandrolone, HU133A |
| GSM30674 |
DMD Subject 3, post-oxandrolone, HU133A |
| GSM30675 |
DMD Subject 1, baseline, HU133B |
| GSM30676 |
DMD Subject 2, baseline, HU133B |
| GSM30677 |
DMD Subject 3, baseline, HU133B |
| GSM30678 |
DMD Subject 1, post-oxandrolone, HU133B |
| GSM30679 |
DMD Subject 2, post-oxandrolone, HU133B |
| GSM30680 |
DMD Subject 3, post-oxandrolone, HU133B |
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| Relations |
| BioProject |
PRJNA90307 |
| Supplementary data files not provided |
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