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| Status |
Public on Aug 07, 2022 |
| Title |
Transcriptomic analysis of the livers of Bnc2 heterozygous or wild-type mice fed with a pro-fibrogenic NASH diet |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
The Ayu21-18 mouse line (B6;CBA-Bnc2Gt(pU21)18Imeg/Orl; Infrafrontier EM-05043) was used to generate mice with heterozygous inactivation of Bnc2,which were compared to their wild-type (WT) littermates. Mice were fed a pro-fibrogenic NASH diet for 7.5 weeks and livers were used used to prepare RNA.
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| Overall design |
Adult male mice were fed with a CDAA-HFSC diet consisting of ad libitum feeding with a choline-deficient, L-amino acid-defined (CDAA) diet supplemented with 35% sucrose, 21% fat and 2% cholesterol. Control mice were fed with a chow diet containing 12% sucrose and 7% fat (Ssniff, custom diets). Livers were used to prepare RNA which was then processed for analysis using MoGene-2_0-st Affymetrix microarrays according to standard procedures.
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| Contributor(s) |
Bobowski-Gerard M, Gheeraert C, Eeckhoute J |
| Citation(s) |
36088459 |
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| Submission date |
Oct 07, 2021 |
| Last update date |
Sep 27, 2022 |
| Contact name |
Jérôme Eeckhoute |
| E-mail(s) |
jerome.eeckhoute@inserm.fr
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| Organization name |
CNRS
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| Lab |
INSERM UMR 1011, Université Lille-Nord de France
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| Street address |
Bâtiment J&K, Faculté de Médecine de Lille-Pôle Recherche, Boulevard du Professeur Leclerc
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| City |
Lille |
| ZIP/Postal code |
59045 |
| Country |
France |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (20)
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| GSM5617700 |
Liver of WT mouse under CDAA-HSFC diet #1 |
| GSM5617701 |
Liver of WT mouse under CDAA-HSFC diet #2 |
| GSM5617702 |
Liver of WT mouse under CDAA-HSFC diet #3 |
| GSM5617703 |
Liver of WT mouse under CDAA-HSFC diet #4 |
| GSM5617704 |
Liver of WT mouse under CDAA-HSFC diet #5 |
| GSM5617705 |
Liver of WT mouse under CDAA-HSFC diet #6 |
| GSM5617706 |
Liver of WT mouse under CDAA-HSFC diet #7 |
| GSM5617707 |
Liver of WT mouse under CDAA-HSFC diet #8 |
| GSM5617708 |
Liver of WT mouse under CDAA-HSFC diet #9 |
| GSM5617709 |
Liver of WT mouse under CDAA-HSFC diet #10 |
| GSM5617710 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #1 |
| GSM5617711 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #2 |
| GSM5617712 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #3 |
| GSM5617713 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #4 |
| GSM5617714 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #5 |
| GSM5617715 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #6 |
| GSM5617716 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #7 |
| GSM5617717 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #8 |
| GSM5617718 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #9 |
| GSM5617719 |
Liver of Bnc2 heterozygous mouse under CDAA-HSFC diet #10 |
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| This SubSeries is part of SuperSeries: |
| GSE185529 |
BNC2 regulated genes in myofibroblasts and liver fibrosis |
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| Relations |
| BioProject |
PRJNA769442 |
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