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Series GSE210598 Query DataSets for GSE210598
Status Public on Dec 23, 2022
Title Genomic profiles of asbestos-induced mesothelioma developed in wild-type and BRCA1+/- SD rats
Organism Rattus norvegicus
Experiment type Genome variation profiling by genome tiling array
Summary Intraperitoneal administration of crocidolite or chrysotile is an established method to induce peritoneal malignant mesothelioma(MM), which shares common genetic alterations to those in humans. We conducted high-resolution microarray comparative genomic hybridization mesothelioma tissues obtained from both wild-type and BRCA1+/- rats to evaluate the involvement of BRCA1 haploinsufficiency in carcinogenesis.
Overall design The carcinogenesis protocol was started with 37 BRCA1+/- and 37 wild-type Jcl: SD rats. 26/37 (70.2%) of BRCA1+/- rats and 27/37 (72.9%) wild-type rats developed MMs in total. Genomes of 8 samples from MMs for each genotype (16 in total) were profiled on Agilent 180K rat genome CGH microarrays.
Contributor(s) Luo Y, Akatsuka S, Toyokuni S
Citation(s) 36541514
Submission date Aug 05, 2022
Last update date Dec 25, 2022
Contact name Shinya Toyokuni
Organization name Nagoya University
Department Pathology
Street address 65 Tsuruma-Cho, Showa-Ku
City Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
Platforms (1)
GPL10451 Agilent-027064 SurePrint G3 Rat CGH Microarray 4x180K
Samples (16)
GSM6433299 Mesothelioma_52805
GSM6433300 Mesothelioma_52813
GSM6433301 Mesothelioma_52406
BioProject PRJNA866397

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE210598_RAW.tar 799.4 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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