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| Status |
Public on Dec 23, 2022 |
| Title |
Genomic profiles of asbestos-induced mesothelioma developed in wild-type and BRCA1+/- SD rats |
| Organism |
Rattus norvegicus |
| Experiment type |
Genome variation profiling by genome tiling array
|
| Summary |
Intraperitoneal administration of crocidolite or chrysotile is an established method to induce peritoneal malignant mesothelioma(MM), which shares common genetic alterations to those in humans. We conducted high-resolution microarray comparative genomic hybridization mesothelioma tissues obtained from both wild-type and BRCA1+/- rats to evaluate the involvement of BRCA1 haploinsufficiency in carcinogenesis.
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| Overall design |
The carcinogenesis protocol was started with 37 BRCA1+/- and 37 wild-type Jcl: SD rats. 26/37 (70.2%) of BRCA1+/- rats and 27/37 (72.9%) wild-type rats developed MMs in total. Genomes of 8 samples from MMs for each genotype (16 in total) were profiled on Agilent 180K rat genome CGH microarrays.
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| Contributor(s) |
Luo Y, Akatsuka S, Toyokuni S |
| Citation(s) |
36541514 |
| |
| Submission date |
Aug 05, 2022 |
| Last update date |
Dec 25, 2022 |
| Contact name |
Shinya Toyokuni |
| E-mail(s) |
akatsuka@med.nagoya-u.ac.jp
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| Organization name |
Nagoya University
|
| Department |
Pathology
|
| Street address |
65 Tsuruma-Cho, Showa-Ku
|
| City |
Nagoya |
| State/province |
Aichi |
| ZIP/Postal code |
466-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL10451 |
Agilent-027064 SurePrint G3 Rat CGH Microarray 4x180K |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA866397 |
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