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| Status |
Public on Feb 26, 2024 |
| Title |
Circulating microRNAs associated to cerebrospinal fluid amyloid-β and phosphorylated tau levels as potential non-invasive biomarkers for mild cognitive impairment and Alzheimer’s disease |
| Organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by high throughput sequencing
|
| Summary |
To identify the potential biomarkers of Alzheimer's disease (AD) based on circulating microRNAs (miRNAs), we developed a new approach using feature selection and linear mixed model. The miRNA sequencing data of 105 plasma and 112 serum samples from 112 subjects including 28 AD cases, 63 mild cognitive impairment (MCI), and 21 controls were used to identify cerebrospinal fluid biomarkers associated miRNAs. The potential of these miRNAs as biomarkers of AD or MCI was researched and validated via both internal and external dataset. Patient classification was effectuated in compliance with the NIA-AA criteria for “MCI due to AD” and “Dementia due to AD”.
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| Overall design |
The recognition of potential biomarkers for Alzheimer’s disease based on the microRNA sequencing data of 105 plasma and 112 serum samples from 112 subjects.
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| |
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| Contributor(s) |
Briedé JJ, Krauskopf J |
| Citation(s) |
38407050 |
| |
| Submission date |
Oct 14, 2022 |
| Last update date |
Feb 26, 2024 |
| Contact name |
Qingfeng Wen |
| E-mail(s) |
q.wen@maastrichtuniversity.nl
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| Phone |
0620144388
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| Organization name |
Maastricht University
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| Department |
Department of Toxicogenomics
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| Street address |
Universiteitssingel 40
|
| City |
Maastricht |
| State/province |
Limburg |
| ZIP/Postal code |
6229ER |
| Country |
Netherlands |
| |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (217)
|
| GSM6640106 |
Plasma,MCI,3 |
| GSM6640107 |
Plasma,AD,7 |
| GSM6640108 |
Plasma,MCI,4 |
| GSM6640109 |
Plasma,MCI,5 |
| GSM6640110 |
Plasma,MCI,6 |
| GSM6640111 |
Plasma,MCI,7 |
| GSM6640112 |
Plasma,MCI,8 |
| GSM6640113 |
Plasma,AD,8 |
| GSM6640114 |
Plasma,MCI,9 |
| GSM6640115 |
Plasma,MCI,10 |
| GSM6640116 |
Plasma,MCI,11 |
| GSM6640117 |
Plasma,MCI,12 |
| GSM6640118 |
Plasma,MCI,13 |
| GSM6640119 |
Plasma,MCI,14 |
| GSM6640120 |
Plasma,MCI,15 |
| GSM6640121 |
Plasma,MCI,16 |
| GSM6640122 |
Plasma,AD,9 |
| GSM6640123 |
Plasma,MCI,17 |
| GSM6640124 |
Plasma,MCI,18 |
| GSM6640125 |
Plasma,MCI,19 |
| GSM6640126 |
Plasma,AD,10 |
| GSM6640127 |
Plasma,AD,11 |
| GSM6640128 |
Plasma,MCI,20 |
| GSM6640129 |
Plasma,MCI,21 |
| GSM6640130 |
Plasma,MCI,23 |
| GSM6640131 |
Plasma,AD,12 |
| GSM6640132 |
Plasma,MCI,24 |
| GSM6640133 |
Plasma,AD,13 |
| GSM6640134 |
Plasma,MCI,25 |
| GSM6640135 |
Plasma,MCI,26 |
| GSM6640136 |
Plasma,MCI,27 |
| GSM6640137 |
Plasma,MCI,28 |
| GSM6640138 |
Plasma,MCI,29 |
| GSM6640139 |
Plasma,Control,1 |
| GSM6640140 |
Plasma,AD,14 |
| GSM6640141 |
Plasma,MCI,30 |
| GSM6640142 |
Plasma,MCI,31 |
| GSM6640143 |
Plasma,AD,15 |
| GSM6640144 |
Plasma,Control,2 |
| GSM6640145 |
Plasma,AD,16 |
| GSM6640146 |
Plasma,Control,3 |
| GSM6640147 |
Plasma,AD,17 |
| GSM6640148 |
Plasma,MCI,32 |
| GSM6640149 |
Plasma,AD,18 |
| GSM6640150 |
Plasma,Control,4 |
| GSM6640151 |
Plasma,MCI,33 |
| GSM6640152 |
Plasma,MCI,34 |
| GSM6640153 |
Plasma,MCI,35 |
| GSM6640154 |
Plasma,Control,5 |
| GSM6640155 |
Plasma,MCI,36 |
| GSM6640156 |
Plasma,MCI,37 |
| GSM6640157 |
Plasma,MCI,38 |
| GSM6640158 |
Plasma,AD,19 |
| GSM6640159 |
Plasma,AD,20 |
| GSM6640160 |
Plasma,MCI,40 |
| GSM6640161 |
Plasma,MCI,41 |
| GSM6640162 |
Plasma,AD,21 |
| GSM6640163 |
Plasma,AD,22 |
| GSM6640164 |
Plasma,AD,23 |
| GSM6640165 |
Plasma,AD,24 |
| GSM6640166 |
Plasma,AD,25 |
| GSM6640167 |
Plasma,MCI,42 |
| GSM6640168 |
Plasma,MCI,43 |
| GSM6640169 |
Plasma,AD,26 |
| GSM6640170 |
Plasma,AD,27 |
| GSM6640171 |
Plasma,MCI,44 |
| GSM6640172 |
Plasma,MCI,45 |
| GSM6640173 |
Plasma,MCI,46 |
| GSM6640174 |
Plasma,MCI,47 |
| GSM6640175 |
Plasma,MCI,48 |
| GSM6640176 |
Plasma,MCI,49 |
| GSM6640177 |
Plasma,MCI,50 |
| GSM6640178 |
Plasma,MCI,51 |
| GSM6640179 |
Plasma,MCI,52 |
| GSM6640180 |
Plasma,Control,6 |
| GSM6640181 |
Plasma,Control,7 |
| GSM6640182 |
Plasma,MCI,53 |
| GSM6640183 |
Plasma,MCI,54 |
| GSM6640184 |
Plasma,Control,8 |
| GSM6640185 |
Plasma,MCI,55 |
| GSM6640186 |
Plasma,MCI,56 |
| GSM6640187 |
Plasma,MCI,57 |
| GSM6640188 |
Plasma,Control,9 |
| GSM6640189 |
Plasma,MCI,58 |
| GSM6640190 |
Plasma,Control,10 |
| GSM6640191 |
Plasma,Control,11 |
| GSM6640192 |
Plasma,MCI,59 |
| GSM6640193 |
Plasma,Control,12 |
| GSM6640194 |
Plasma,Control,13 |
| GSM6640195 |
Plasma,MCI,60 |
| GSM6640196 |
Plasma,MCI,61 |
| GSM6640197 |
Plasma,Control,14 |
| GSM6640198 |
Plasma,AD,28 |
| GSM6640199 |
Plasma,Control,15 |
| GSM6640200 |
Plasma,Control,16 |
| GSM6640201 |
Plasma,Control,17 |
| GSM6640202 |
Plasma,MCI,62 |
| GSM6640203 |
Plasma,Control,18 |
| GSM6640204 |
Plasma,Control,19 |
| GSM6640205 |
Plasma,Control,20 |
| GSM6640206 |
Plasma,Control,21 |
| GSM6640207 |
Plasma,MCI,63 |
| GSM6640208 |
Serum,AD,1 |
| GSM6640209 |
Serum,AD,2 |
| GSM6640210 |
Serum,AD,3 |
| GSM6640211 |
Serum,AD,4 |
| GSM6640212 |
Serum,AD,5 |
| GSM6640213 |
Serum,MCI,1 |
| GSM6640214 |
Serum,MCI,2 |
| GSM6640215 |
Serum,AD,6 |
| GSM6640216 |
Serum,MCI,3 |
| GSM6640217 |
Serum,AD,7 |
| GSM6640218 |
Serum,MCI,4 |
| GSM6640219 |
Serum,MCI,5 |
| GSM6640220 |
Serum,MCI,6 |
| GSM6640221 |
Serum,MCI,7 |
| GSM6640222 |
Serum,MCI,8 |
| GSM6640223 |
Serum,AD,8 |
| GSM6640224 |
Serum,MCI,9 |
| GSM6640225 |
Serum,MCI,10 |
| GSM6640226 |
Serum,MCI,11 |
| GSM6640227 |
Serum,MCI,12 |
| GSM6640228 |
Serum,MCI,13 |
| GSM6640229 |
Serum,MCI,14 |
| GSM6640230 |
Serum,MCI,15 |
| GSM6640231 |
Serum,MCI,16 |
| GSM6640232 |
Serum,AD,9 |
| GSM6640233 |
Serum,MCI,17 |
| GSM6640234 |
Serum,MCI,18 |
| GSM6640235 |
Serum,MCI,19 |
| GSM6640236 |
Serum,AD,10 |
| GSM6640237 |
Serum,AD,11 |
| GSM6640238 |
Serum,MCI,20 |
| GSM6640239 |
Serum,MCI,21 |
| GSM6640240 |
Serum,MCI,22 |
| GSM6640241 |
Serum,MCI,23 |
| GSM6640242 |
Serum,AD,12 |
| GSM6640243 |
Serum,MCI,24 |
| GSM6640244 |
Serum,AD,13 |
| GSM6640245 |
Serum,MCI,25 |
| GSM6640246 |
Serum,MCI,26 |
| GSM6640247 |
Serum,MCI,27 |
| GSM6640248 |
Serum,MCI,28 |
| GSM6640249 |
Serum,MCI,29 |
| GSM6640250 |
Serum,Control,1 |
| GSM6640251 |
Serum,AD,14 |
| GSM6640252 |
Serum,MCI,30 |
| GSM6640253 |
Serum,MCI,31 |
| GSM6640254 |
Serum,AD,15 |
| GSM6640255 |
Serum,Control,2 |
| GSM6640256 |
Serum,AD,16 |
| GSM6640257 |
Serum,Control,3 |
| GSM6640258 |
Serum,AD,17 |
| GSM6640259 |
Serum,MCI,32 |
| GSM6640260 |
Serum,AD,18 |
| GSM6640261 |
Serum,Control,4 |
| GSM6640262 |
Serum,MCI,33 |
| GSM6640263 |
Serum,MCI,34 |
| GSM6640264 |
Serum,MCI,35 |
| GSM6640265 |
Serum,Control,5 |
| GSM6640266 |
Serum,MCI,36 |
| GSM6640267 |
Serum,MCI,37 |
| GSM6640268 |
Serum,MCI,38 |
| GSM6640269 |
Serum,MCI,39 |
| GSM6640270 |
Serum,AD,19 |
| GSM6640271 |
Serum,AD,20 |
| GSM6640272 |
Serum,MCI,40 |
| GSM6640273 |
Serum,MCI,41 |
| GSM6640274 |
Serum,AD,21 |
| GSM6640275 |
Serum,AD,22 |
| GSM6640276 |
Serum,AD,23 |
| GSM6640277 |
Serum,AD,24 |
| GSM6640278 |
Serum,AD,25 |
| GSM6640279 |
Serum,MCI,42 |
| GSM6640280 |
Serum,MCI,43 |
| GSM6640281 |
Serum,AD,26 |
| GSM6640282 |
Serum,AD,27 |
| GSM6640283 |
Serum,MCI,44 |
| GSM6640284 |
Serum,MCI,45 |
| GSM6640285 |
Serum,MCI,46 |
| GSM6640286 |
Serum,MCI,47 |
| GSM6640287 |
Serum,MCI,48 |
| GSM6640288 |
Serum,MCI,49 |
| GSM6640289 |
Serum,MCI,50 |
| GSM6640290 |
Serum,MCI,51 |
| GSM6640291 |
Serum,MCI,52 |
| GSM6640292 |
Serum,Control,6 |
| GSM6640293 |
Serum,Control,7 |
| GSM6640294 |
Serum,MCI,53 |
| GSM6640295 |
Serum,MCI,54 |
| GSM6640296 |
Serum,Control,8 |
| GSM6640297 |
Serum,MCI,55 |
| GSM6640298 |
Serum,MCI,56 |
| GSM6640299 |
Serum,MCI,57 |
| GSM6640300 |
Serum,Control,9 |
| GSM6640301 |
Serum,MCI,58 |
| GSM6640302 |
Serum,Control,10 |
| GSM6640303 |
Serum,Control,11 |
| GSM6640304 |
Serum,MCI,59 |
| GSM6640305 |
Serum,Control,12 |
| GSM6640306 |
Serum,Control,13 |
| GSM6640307 |
Serum,MCI,60 |
| GSM6640308 |
Serum,MCI,61 |
| GSM6640309 |
Serum,Control,14 |
| GSM6640310 |
Serum,AD,28 |
| GSM6640311 |
Serum,Control,15 |
| GSM6640312 |
Serum,Control,16 |
| GSM6640313 |
Serum,Control,17 |
| GSM6640314 |
Serum,MCI,62 |
| GSM6640315 |
Serum,Control,18 |
| GSM6640316 |
Serum,Control,19 |
| GSM6640317 |
Serum,Control,20 |
| GSM6640318 |
Serum,Control,21 |
| GSM6640319 |
Serum,MCI,63 |
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| Relations |
| BioProject |
PRJNA890618 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE215789_miR.Counts_plasma.csv.gz |
87.3 Kb |
(ftp)(http) |
CSV |
| GSE215789_miR.Counts_serum.csv.gz |
80.0 Kb |
(ftp)(http) |
CSV |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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