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| Status |
Public on Jun 10, 2010 |
| Title |
Effect of 52 weeks of chronic exposure to TCDD AND PCB126 on hepatic gene expression |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
|
| Summary |
This study investigates the effects of the aryl hydrocarbon receptor (AhR) ligands TCDD and PCB126 on hepatic gene expression in female sprague dawley rats. Rats were treated with toxicological equivalent doses of TCDD (100ng/kg/day) (Toxic equivalence factor (TEF) = 1.0), PCB126 (30ng, 300ng or 1000ng/kg/day) (TEF = 0.1) or a vehicle control of corn oil:acetone (99:1) 5 days a week for 52 weeks.
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| Overall design |
There are 3 control chips and representing animals treated with vehicle control. There are 3 biological replicates (3 chips) for each treatment group (eg. TCDD, PCB126), each biological replicate is derived from 2 individual animals. A total of 15 chips were analyzed.
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| Contributor(s) |
Ovando BJ, Ellison CA, Vezina CM, Olson JR |
| Citation(s) |
20959002 |
| |
| Submission date |
Jun 09, 2010 |
| Last update date |
Feb 21, 2017 |
| Contact name |
Corie Ellison |
| Organization name |
University at Buffalo
|
| Department |
Pharmacology and Toxicology
|
| Lab |
James Olson
|
| Street address |
102 Farber hall
|
| City |
Buffalo |
| State/province |
NY |
| ZIP/Postal code |
14214 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL85 |
[RG_U34A] Affymetrix Rat Genome U34 Array |
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| Samples (15)
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| Relations |
| BioProject |
PRJNA128739 |
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