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| Status |
Public on Oct 01, 2010 |
| Title |
Lack of chemokine signaling through CXCR5 causes mortality, ventricular dilatation and deranged matrix during pressure overload |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Inflammatory mechanisms have been suggested to play a role in the development of heart failure (HF), but a role for chemokines is largely unknown. The aim of this study was to analyze the role of the chemokine CXCL13 and its receptor CXCR5 in cardiac pathophysiology leading to HF
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| Overall design |
A microarray study was performed on seven mice harboring a systemic knockout of the CXCR5 (CXCR5-/-) and seven wildtype mice. Four of the knockouts and four of the wild type mice were subjected to aorta banding and three of each to sham operations.
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| Contributor(s) |
Wæhre A, Nygård S, Christensen G |
| Citation(s) |
21533157 |
| Submission date |
Jun 10, 2010 |
| Last update date |
Mar 04, 2019 |
| Contact name |
Ståle Nygård |
| E-mail(s) |
stale.nygard@medisin.uio.no
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| Phone |
+47 95129127
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| Organization name |
University of Oslo
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| Street address |
Institute for Experimental Medical Research, Oslo University Hospital - Ulleval
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| City |
Oslo |
| ZIP/Postal code |
0407 |
| Country |
Norway |
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| Platforms (1) |
| GPL6246 |
[MoGene-1_0-st] Affymetrix Mouse Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (14)
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| GSM554832 |
left ventricle, aorta banding, cxcr5 knockout, rep1 |
| GSM554833 |
left ventricle, aorta banding, cxcr5 knockout, rep2 |
| GSM554834 |
left ventricle, aorta banding, cxcr5 knockout, rep3 |
| GSM554835 |
left ventricle, aorta banding, cxcr5 knockout, rep4 |
| GSM554836 |
left ventricle, aorta banding, wildtype, rep1 |
| GSM554837 |
left ventricle, aorta banding, wildtype, rep2 |
| GSM554838 |
left ventricle, aorta banding, wildtype, rep3 |
| GSM554839 |
left ventricle, aorta banding, wildtype, rep4 |
| GSM554840 |
left ventricle, sham, cxcr5 knockout, rep1 |
| GSM554841 |
left ventricle, sham, cxcr5 knockout, rep2 |
| GSM554842 |
left ventricle, sham, cxcr5 knockout, rep3 |
| GSM554843 |
left ventricle, sham, wildtype, rep1 |
| GSM554844 |
left ventricle, sham, wildtype, rep2 |
| GSM554845 |
left ventricle, sham, wildtype, rep3 |
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| Relations |
| BioProject |
PRJNA127413 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE22295_RAW.tar |
53.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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