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| Status |
Public on Jan 29, 2024 |
| Title |
Association of SNPs in the PAI1 Gene with Disease Recurrence and Clinical Outcome in Bladder Cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Bladder cancer is one of the most common cancer types worldwide and is characterized by a high rate of recurrence. Previous studies have demonstrated that plasminogen activator inhibi-tor-1 (PAI1) plays an important role in bladder cancer development. The aim of our retrospective study was to assess the effects of PAI1 mutational status in bladder tumors. In this study, we evaluated the mutational status of PAI1 in a series of independent cohorts, comprised of a total of 660 subjects. We identified two clinically relevant 3’ untranslated region (UTR) single nucleotide polymorphisms (SNPs) in PAI1. Caucasian patients with at least one of the SNPs had high risk of recurrence and shorter survival. Additional studies using cell lines demonstrated that one SNP increased the anti-apoptotic effect of PAI1, and another lose the control of cancer cellular growth. This study underscores the relevance and influence of these SNPs in bladder cancer.
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| Overall design |
We transfected mock, PAI1 WT, or PAI1 mutant plasmids in 2 human urothelial cell lines, and then performed microarray
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| Web link |
https://www.mdpi.com/1422-0067/24/5/4943
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| |
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| Contributor(s) |
Furuya H, Rosser C |
| Citation(s) |
36902377 |
| |
| Submission date |
Feb 01, 2023 |
| Last update date |
Jan 30, 2024 |
| Contact name |
Hideki Furuya |
| E-mail(s) |
hideki.furuya@cshs.org
|
| Phone |
3104234607
|
| Organization name |
Cedars Sinai Medical Center
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| Department |
Surgery
|
| Street address |
110 N. George Burns Road, Davis 2025
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90048 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA930502 |
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