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| Status |
Public on Apr 23, 2024 |
| Title |
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia |
| Organisms |
Homo sapiens; Mus musculus |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by high throughput sequencing
|
| Summary |
Here we report a new fusion gene, STRN3-RARA, in acute promyelocytic leukemia (APL). It cooperates with UTX deficiency to drive full-blown APL in mice. Although STRN3-RARA leukemia quickly relapses after all-trans retinoic acid treatment, it can be restrained by cepharanthine.
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| Overall design |
Refer to individual Series
|
| Web link |
https://ashpublications.org/blood/article-abstract/142/17/1494/497635/Identifying-STRN3-RARA-as-a-new-fusion-gene-for?redirectedFrom=fulltext
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| |
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| Citation(s) |
37624915 |
| |
| Submission date |
Feb 08, 2023 |
| Last update date |
Apr 24, 2024 |
| Contact name |
Xaingyu Pan |
| E-mail(s) |
pangxueyu233@outlook.com
|
| Organization name |
Sichuan University
|
| Department |
State Key Laboratory of Biotherapy, West China Hospital, Sihcuan University.
|
| Lab |
Chen & Liu Lab
|
| Street address |
No.17 Renming road section3
|
| City |
Chengdu, Cihna |
| State/province |
Sichuan |
| ZIP/Postal code |
610041 |
| Country |
China |
| |
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| Platforms (2) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (22)
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| This SuperSeries is composed of the following SubSeries: |
| GSE224813 |
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia [CUT&TAG] |
| GSE224815 |
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia [RNA-seq] |
| GSE239350 |
Identifying STRN3-RARA as a new fusion gene for acute promyelocytic leukemia [RNA-seq 2] |
|
| Relations |
| BioProject |
PRJNA932745 |
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