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| Status |
Public on Apr 05, 2023 |
| Title |
Transcriptomic changes in the medial prefrontal cortex of juvenile rat offspring after induced birth with oxytocin |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report changes in the medial prefrontal cortical transcriptome of male and female rat offspring after induced birth with oxytocin using RNA-seq analysis.
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| Overall design |
We performed RNA-seq analysis to examine differential gene expression in the mPFC of P45 male and female rat offspring after elective birth induction with oxytocin or saline (n=6 animals/sex/treatment). With an FDR adjusted p ≤ 0.05 and linear FC ≥ 2, we identified a small number of mostly non-overlapping genes that were significantly differently expressed in male and female oxytocin-exposed offspring.
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| Contributor(s) |
Palanisamy A |
| Citation(s) |
38327784 |
| Submission date |
Apr 04, 2023 |
| Last update date |
Feb 15, 2024 |
| Contact name |
Arvind Palanisamy |
| E-mail(s) |
arvind.palanisamy@wustl.edu
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| Organization name |
Washington University School of Medicine
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| Department |
Anesthesiology
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| Street address |
660 S Euclid Ave
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| City |
St. Louis |
| State/province |
MO |
| ZIP/Postal code |
63110 |
| Country |
USA |
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| Platforms (1) |
| GPL25947 |
Illumina NovaSeq 6000 (Rattus norvegicus) |
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| Samples (24)
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| GSM7142545 |
mPFC, sal_m3 |
| GSM7142546 |
mPFC, sal_m2 |
| GSM7142547 |
mPFC, sal_m1 |
| GSM7142548 |
mPFC, sal_f6 |
| GSM7142549 |
mPFC, sal_f5 |
| GSM7142550 |
mPFC, sal_f4 |
| GSM7142551 |
mPFC, sal_f3 |
| GSM7142552 |
mPFC, sal_f2 |
| GSM7142553 |
mPFC, sal_f1 |
| GSM7142554 |
mPFC, oxt_m6 |
| GSM7142555 |
mPFC, oxt_m5 |
| GSM7142556 |
mPFC, oxt_m4 |
| GSM7142557 |
mPFC, oxt_m3 |
| GSM7142558 |
mPFC, oxt_m2 |
| GSM7142559 |
mPFC, oxt_m1 |
| GSM7142560 |
mPFC, oxt_f6 |
| GSM7142561 |
mPFC, oxt_f5 |
| GSM7142562 |
mPFC, oxt_f4 |
| GSM7142563 |
mPFC, oxt_f3 |
| GSM7142564 |
mPFC, oxt_f2 |
| GSM7142565 |
mPFC, oxt_f1 |
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| Relations |
| BioProject |
PRJNA952158 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE228913_RAW.tar |
9.1 Mb |
(http)(custom) |
TAR (of SF) |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data provided as supplementary file |
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