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| Status |
Public on Oct 01, 2011 |
| Title |
Cannabinoid Receptor 1 Dependent Effects of Isopropoyl dodeycl fluorophosphonate on Hepatic Gene Expression |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
We tested the effects of isopropoyl dodecyl fluorophosphonate (IDFP) (10 mg/kg, i.p.), a pharmacological inhibitor of endocannabinoid degradation, on hepatic gene expression in mice. To determine if increased cannabinoid receptor 1 signaling is responsible for IDFP induced effects a subset of mice were pretreated with the cannabinoid receptor 1 antagonist (AM251) (10 mg/kg, i.p.).
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| Overall design |
Total RNA obtained from liver of mice treated with DMSO (n=6), IDFP (n=8), or AM251/IDFP (n=5) (all 10 mg/kg i.p.) for 4 hours.
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| |
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| Contributor(s) |
Ruby MA, Krauss RM |
| Citation(s) |
22073164 |
| |
| Submission date |
Jul 15, 2010 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Max Ruby |
| E-mail(s) |
mruby@chori.org
|
| Organization name |
Children's Hospital Oakland Reserach Institue
|
| Lab |
Krauss
|
| Street address |
5700 Martin Luther King Jr. Way
|
| City |
OAKLAND |
| State/province |
CA |
| ZIP/Postal code |
94609 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (19)
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| Relations |
| BioProject |
PRJNA127797 |
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