|
| Status |
Public on Jul 31, 2024 |
| Title |
Chronic sleep fragmentation reduces left ventricular contractile function and alters gene expression related to innate immune response and circadian rhythm in the mouse heart |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Purpose: The purpose of this study was to comprehensively identify the gene expression changes that occur after chronic sleep fragmentation. Method: We conducted total microarray analysis of the heart in mice following 5 weeks of sleep fragmentation. Results: The microarray analysis revealed significant and dramatic gene expression changes in the mouse heart as a result of chronic sleep fragmentation. Conclusion: This study provides valuable insights into the biological impact of chronic sleep fragmentation, shedding light on the molecular mechanisms involved.
|
| |
|
| Overall design |
Microarray analysis was conducted on 21-week-old female C57BL/6N mice who were subjected to either 5 weeks of sleep fragmentation or left undisturbed.
|
| |
|
| Contributor(s) |
Zhong L, Wang D, Li B, Yi X, Xiao Y, Li X, Li M, Gao S |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jul 03, 2023 |
| Last update date |
Jul 31, 2024 |
| Contact name |
Ling Zhong |
| E-mail(s) |
zhongling1222@gmail.com
|
| Organization name |
Peking Union Medical College Hospital
|
| Department |
Department of Endocrinology
|
| Street address |
Wangfujing Street
|
| City |
Beijing |
| ZIP/Postal code |
100730 |
| Country |
China |
| |
|
| Platforms (1) |
| GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
|
| Samples (6)
|
| GSM7528390 |
heart_sleep fragmented_5 weeks_Control 1 |
| GSM7528391 |
heart_sleep fragmented_5 weeks_Control 2 |
| GSM7528392 |
heart_sleep fragmented_5 weeks_Control 3 |
|
| Relations |
| BioProject |
PRJNA990695 |
Less...
More...