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Status |
Public on Jul 31, 2024 |
Title |
Chronic sleep fragmentation reduces left ventricular contractile function and alters gene expression related to innate immune response and circadian rhythm in the mouse heart |
Organism |
Mus musculus |
Experiment type |
Expression profiling by array
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Summary |
Purpose: The purpose of this study was to comprehensively identify the gene expression changes that occur after chronic sleep fragmentation. Method: We conducted total microarray analysis of the heart in mice following 5 weeks of sleep fragmentation. Results: The microarray analysis revealed significant and dramatic gene expression changes in the mouse heart as a result of chronic sleep fragmentation. Conclusion: This study provides valuable insights into the biological impact of chronic sleep fragmentation, shedding light on the molecular mechanisms involved.
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Overall design |
Microarray analysis was conducted on 21-week-old female C57BL/6N mice who were subjected to either 5 weeks of sleep fragmentation or left undisturbed.
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Contributor(s) |
Zhong L, Wang D, Li B, Yi X, Xiao Y, Li X, Li M, Gao S |
Citation missing |
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Submission date |
Jul 03, 2023 |
Last update date |
Jul 31, 2024 |
Contact name |
Ling Zhong |
E-mail(s) |
zhongling1222@gmail.com
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Organization name |
Peking Union Medical College Hospital
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Department |
Department of Endocrinology
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Street address |
Wangfujing Street
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City |
Beijing |
ZIP/Postal code |
100730 |
Country |
China |
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Platforms (1) |
GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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Samples (6)
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GSM7528390 |
heart_sleep fragmented_5 weeks_Control 1 |
GSM7528391 |
heart_sleep fragmented_5 weeks_Control 2 |
GSM7528392 |
heart_sleep fragmented_5 weeks_Control 3 |
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Relations |
BioProject |
PRJNA990695 |