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Series GSE241162 Query DataSets for GSE241162
Status Public on May 30, 2024
Title Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment - microarray
Organism Mus musculus
Experiment type Expression profiling by array
Summary To understand transcriptional aberrations induced by oncogenic Calreticulin (Calr) in myeloproliferative neoplasms we used a cell line – 32D, generated from the murine myeloid precursor cells, to overexpress human thrombopoietin receptor (MPL) together with human Calr. Cells expressing oncogenic Calr show increased JAK/STAT signaling independent of extrinsic stimuli like IL3.
 
Overall design A total of 8 samples were prepared, split in two groups. 4 replicates from 32D cells transduced with MPL + Calr(WT) and 4 replicates from 32D cells transduced with MPL + Calr(ins5).
 
Contributor(s) Schmidt D, Zeiser R, Andrieux G, Boerries M
Citation missing Has this study been published? Please login to update or notify GEO.
Submission date Aug 18, 2023
Last update date May 31, 2024
Contact name Geoffroy Andrieux
Organization name University clinics Freiburg
Street address Breisacherstr 153
City Freiburg
ZIP/Postal code 79110
Country Germany
 
Platforms (1)
GPL23038 [Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay)
Samples (8)
GSM7717553 32D-MPL-Calr(WT) 6
GSM7717554 32D-MPL-Calr(WT) 3
GSM7717555 32D-MPL-Calr(WT) 2
This SubSeries is part of SuperSeries:
GSE241365 Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment
Relations
BioProject PRJNA1006665

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE241162_RAW.tar 9.1 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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