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| Status |
Public on May 30, 2024 |
| Title |
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment - microarray |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To understand transcriptional aberrations induced by oncogenic Calreticulin (Calr) in myeloproliferative neoplasms we used a cell line – 32D, generated from the murine myeloid precursor cells, to overexpress human thrombopoietin receptor (MPL) together with human Calr. Cells expressing oncogenic Calr show increased JAK/STAT signaling independent of extrinsic stimuli like IL3.
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| Overall design |
A total of 8 samples were prepared, split in two groups. 4 replicates from 32D cells transduced with MPL + Calr(WT) and 4 replicates from 32D cells transduced with MPL + Calr(ins5).
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| Contributor(s) |
Schmidt D, Zeiser R, Andrieux G, Boerries M |
| Citation(s) |
38885318 |
| |
| Submission date |
Aug 18, 2023 |
| Last update date |
Sep 09, 2024 |
| Contact name |
Geoffroy Andrieux |
| Organization name |
University clinics Freiburg
|
| Street address |
Breisacherstr 153
|
| City |
Freiburg |
| ZIP/Postal code |
79110 |
| Country |
Germany |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE241365 |
Oncogenic Calreticulin Induces Immune Escape by Stimulating TGF-β Expression and Regulatory T Cell Expansion in the Bone Marrow Microenvironment |
|
| Relations |
| BioProject |
PRJNA1006665 |
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