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| Status |
Public on Feb 20, 2012 |
| Title |
Fish oil/pectin temporally alters gene expression profiles in exfoliated rat colonocytes throughout oncogenesis |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
We have demonstrated that fish oil/pectin (FO/P) diets protect against colon cancer compared to corn oil/cellulose (CO/C) by upregulating apoptosis and suppressing proliferation.
To elucidate the mechanisms whereby FO/P diets induce apoptosis and suppress proliferation during the tumorigenic process, we analyzed the temporal gene expression profiles from exfoliated rat colonocytes.
KEYWORDS: Fish oil/pectin, pectin, exfoliated colonocytes, gene expression, apoptosis, colon cancer, chemoprevention
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| Overall design |
Rats consumed diets containing FO/P or CO/C and were injected with azoxymethane (AOM, 2x, 15 mg/kg BW, s.c.). Feces collected at the initiation, aberrant crypt foci (ACF), and tumor stages of colon cancer (24 h (n=20), 7 wk (n=37), and 28 wk (n=28) after AOM injection, respectively) was used for poly A(+) RNA extraction. Gene expression signatures were determined using Codelink arrays.
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| Contributor(s) |
Lupton JR, Turner ND |
| Citation(s) |
21508209 |
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| Submission date |
Feb 12, 2011 |
| Last update date |
Jun 06, 2014 |
| Contact name |
Youngmi Cho |
| E-mail(s) |
ym473@tamu.edu
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| Phone |
979-845-4887
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| Organization name |
Texas A&M University
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| Department |
Faculty of Nutrition
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| Street address |
2253 TAMU
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| City |
College Station |
| State/province |
TX |
| ZIP/Postal code |
77840 |
| Country |
USA |
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| Platforms (1) |
| GPL2896 |
GE Healthcare/Amersham Biosciences CodeLink™ Rat Whole Genome Bioarray |
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| Samples (89)
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| Relations |
| BioProject |
PRJNA137145 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE27266_RAW.tar |
149.6 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
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