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| Status |
Public on Jul 29, 2013 |
| Title |
Rapamycin extends life span, but has limited effects on aging in mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Rapamycin extends life span in mice, but it remains unclear if this compound also delays mammalian aging. Here, we present results from a comprehensive large-scale assessment of a wide rage of structural and functional aging phenotypes in mice. Rapamycin extended life span but showed few effects on a large number of systemic aging phenotypes, suggesting that rapamycin's effects on aging are largely limited to the regulation of age-related mortality and carcinogenesis.
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| |
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| Overall design |
Total RNA obtained from 2-4 male mice of each analysed group (25 weeks old controls, 25 month old controls, 25 month old rapamycin treated)
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| Contributor(s) |
Beckers J, Horsch M |
| Citation(s) |
23863708 |
| |
| Submission date |
Sep 20, 2012 |
| Last update date |
Jun 14, 2018 |
| Contact name |
Martin Irmler |
| Organization name |
Helmholtz Zentrum München GmbH
|
| Department |
Institute of Experimental Genetics
|
| Lab |
Gene Regulation & Epigenetics
|
| Street address |
Ingolstaedter Landstrasse 1
|
| City |
Neuherberg |
| State/province |
Bayern |
| ZIP/Postal code |
85764 |
| Country |
Germany |
| |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (30)
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| Relations |
| BioProject |
PRJNA175551 |
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