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| Status |
Public on Oct 10, 2012 |
| Title |
A comparative analysis of genistein and daidzein in affecting lipid metabolism in rat liver |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by array
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| Summary |
Effects of soy isoflavones, genistein and daidzein, on the hepatic gene expression profile and indices for lipid metabolism were compared in rats.
The GeneChip data was normalized and summarized by using SuperNORM data service (Skylight Biotech Inc.). Significance of expressional change among groups was tested by 2-way ANOVA on the normalized CEL data, which was deposited in a tab-separated ASCII text format. Principal components were identified on the summarized gene data.
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| Overall design |
Three groups of rats were fed with an experimental diet containing 2 g/kg of either genistein or daidzein, or a control diet free of isoflavone for 14 days. The basal composition of the experimental diet was (in g/kg): casein, 200; palm oil, 100; corn starch, 150; cellulose, 20; mineral mixture (AIN-93G), 35; vitamin mixture (AIN-93), 10; L-cystine, 3.0; choline bitartrate, 2.0 and sucrose to 1 kg.
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| Contributor(s) |
Takahashi Y, Odbayar T, Ide T, Konishi T |
| Citation(s) |
19430610 |
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| Submission date |
Oct 09, 2012 |
| Last update date |
Jul 31, 2017 |
| Contact name |
Tomokazu Konishi |
| E-mail(s) |
konishi@akita-pu.ac.jp
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| Phone |
+81-18-872-1603
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| Organization name |
Akita Prefectural University
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| Department |
Bioresource Sciences
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| Lab |
Molecular Genetics
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| Street address |
Shimoshinjyo Nishi
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| City |
Akita |
| State/province |
Akita |
| ZIP/Postal code |
010-0195 |
| Country |
Japan |
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| Platforms (1) |
| GPL1355 |
[Rat230_2] Affymetrix Rat Genome 230 2.0 Array |
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| Samples (15)
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| GSM1016822 |
Non-isoflavone diet, biological rep4 |
| GSM1016823 |
Non-isoflavone diet, biological rep5 |
| GSM1016824 |
Daidzein diet, biological rep1 |
| GSM1016825 |
Daidzein diet, biological rep2 |
| GSM1016826 |
Daidzein diet, biological rep3 |
| GSM1016827 |
Daidzein diet, biological rep4 |
| GSM1016828 |
Daidzein diet, biological rep5 |
| GSM1016829 |
Genistein diet, biological rep1 |
| GSM1016830 |
Genistein diet, biological rep3 |
| GSM1016831 |
Genistein diet, biological rep2 |
| GSM1016832 |
Genistein diet, biological rep4 |
| GSM1016833 |
Genistein diet, biological rep5 |
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| Relations |
| BioProject |
PRJNA176925 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE41420_RAW.tar |
35.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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