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Series GSE49951 Query DataSets for GSE49951
Status Public on Jan 17, 2014
Title A Genomic Portrait of the Genetic Architecture and Regulatory Impact of microRNA Expression in Response to Infection
Organism Homo sapiens
Experiment type Non-coding RNA profiling by array
Summary Identification of changes in microRNA expression, remodelling of relationships between microRNA and mRNA expression levels, and genetic polymorphisms associated with inter-individual variation in the dendritic cell immune response to Mycobacterium tuberculosis infection.
 
Overall design We characterised genome-wide changes in microRNA expression, and of the broader miRNA-mdeiated regulatory system, in response to Mycobacterium tuberculosis (MTB) infection, and assessed the extent to which this response is under genetic control. To do so, we profiled microRNA expression levels in primary dendritic cells from 65 individuals before and after infection with MTB for 18 hours.
 
Contributor(s) Siddle KJ, Deschamps M, Tailleux L, Nédélec Y, Pothlichet J, Lugo-Villarino G, Libri V, Gicquel B, Neyrolles O, Laval G, Patin E, Barreiro LB, Quintana-Murci L
Citation(s) 24482540
Submission date Aug 18, 2013
Last update date Jun 07, 2015
Contact name Katherine Siddle
Organization name Institut Pasteur
Street address 28 rue du Dr Roux
City Paris
ZIP/Postal code 75015
Country France
 
Platforms (1)
GPL16770 Agilent-031181 Unrestricted_Human_miRNA_V16.0_Microarray (miRBase release 16.0 miRNA ID version)
Samples (142)
GSM1210581 HumanDC RNA Sample9 Non-infected 18hours rep1
GSM1210582 HumanDC RNA Sample9 MTB-infected 18hours rep1
GSM1210583 HumanDC RNA Sample23 Non-infected 18hours rep1
Relations
BioProject PRJNA215681

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE49951_RAW.tar 1.1 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

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