|
| Status |
Public on Apr 16, 2014 |
| Title |
Steroid Receptor Coactivator 1 is an Integrator of Glucose and NAD(+)/NADH Homeostasis |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
SRC-1 affects the expression of complex I of the mitochondrial electron transport chain, a set of enzymes responsible for the conversion of NADH to NAD(+). NAD(+) and NADH were subsequently identified as metabolites that underlie SRC-1's response to glucose deprivation. Knockdown of SRC-1 in glycolytic cancer cells abrogated their ability to grow in the absence of glucose consistent with SRC-1's role in promoting cellular adaptation to reduced glucose availability
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| |
|
| Overall design |
RNA profiling was used to examine the effects of SRC-1 perturbation on gene expression in the absence or presence of glucose.
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| |
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| Contributor(s) |
Motamed M, Rajapakshe KI, Hartig SM, Coarfa C, Moses RE, Lonard DM, O'Malley BW |
| Citation(s) |
24438340 |
| |
| Submission date |
Apr 16, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
David Lonard |
| E-mail(s) |
dlonard@bcm.edu
|
| Organization name |
Baylor College of Medicine
|
| Department |
Mol & Cell Biology-Mol.Regulation
|
| Lab |
BCM-Michael Debakey Center, Room M809, MS: BCM130
|
| Street address |
1 Baylor Plaza
|
| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (8)
|
|
| Relations |
| BioProject |
PRJNA244751 |
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