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| Status |
Public on Jan 01, 2015 |
| Title |
Affymetrix SNP array data for adult acute lymphoblastic leukemia samples |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
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| Summary |
Copy number variation (CNV) and loss of heterozygosity (LOH) were investigated in adult Chinese patients with acute lymphoblastic leukemia (ALL), and these patients were screened for adult ALL prognostic genes.The most frequent CNVs are gain at chr13q, loss at chr6 and recurrent LOH at chr17p and 1p33. In Ph- B-ALL patients, the most frequent CNVs are gain at chr7, loss at chr9p and recurrent LOH at chr15q. In T-ALL, the most frequent CNVs are gain at chr20 and 7q, loss at chr2p and recurrent LOH also at chr15q.
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| Overall design |
Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from cryopreserved bone marrow samples.
Copy number analysis of Affymetrix SNP 6.0 arrays was performed for 33 newly diagnosis adult ALL samples, 11 paried complete remission(CR) ALL samples and 1 relapse ALL. There are also 5 healthy donor samples which were used as references for copy number inference.
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| Contributor(s) |
Tian Y, Yingchang M |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Apr 23, 2014 |
| Last update date |
Nov 27, 2018 |
| Contact name |
Tian Yuan |
| E-mail(s) |
mdyuantian@163.com
|
| Organization name |
Peking Union Medical College
|
| Department |
Institute of Hematology and Blood Disease Hospital
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| Lab |
State Key Laboratory of Experimental Hematology
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| Street address |
No.288 Nanjing Road
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| City |
Tianjin |
| ZIP/Postal code |
300020 |
| Country |
China |
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| Platforms (1) |
| GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
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| Samples (50)
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| Relations |
| BioProject |
PRJNA245224 |
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