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| Status |
Public on May 17, 2014 |
| Title |
Molecular effects of capsaicin on human gingival epithelial cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
In order to explain the molecular mechanisms of capsaicin-induced proliferation of gingival epithelial cells (GECs), a microarray analysis was performed. Several cell proliferation related genes were significantly up-regulated. These data suggest that TRPV1 signaling in GEC may induce transcriptional upregulation of growth factors, which results in an increased proliferation rate.
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| Overall design |
Simian virus 40 (SV40) T-antigen-immortalized human gingival epithelial cell line, epi4, were stimulated with 1 μM capsaicin for 4 hours. Total RNA was isolated and subjected to gene expression analysis using Agilent whole human genome oligo microarray.
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| Contributor(s) |
Takahashi N |
| Citation(s) |
25266715 |
| Submission date |
May 16, 2014 |
| Last update date |
Jan 23, 2019 |
| Contact name |
Naoki Takahashi |
| Organization name |
Niigata University Faculty of Dentistry
|
| Department |
Oral Biological Science
|
| Street address |
2-5274 Gakko-cho, Chuo-ku
|
| City |
Niigata |
| ZIP/Postal code |
9518514 |
| Country |
Japan |
| |
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| Platforms (1) |
| GPL6480 |
Agilent-014850 Whole Human Genome Microarray 4x44K G4112F (Probe Name version) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA248012 |
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