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| Status |
Public on Feb 02, 2018 |
| Title |
Transcriptomic analysis of the peripheral nervous system of Schwann cell-conditional FASN knockout mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Myelination calls for a tremendous surge in cell metabolism towards lipids and membrane production. However, functional relevance of de novo fatty acid synthesis in myelinating cells remains unclear. We generated mutant mice in which the enzyme fatty acid synthase (FASN) was depleted conditionally in Schwann cells, the myelinating glial cells of the peripheral nervous system. To address how lack of FASN was affecting the development of the peripheral nervous system, we screened with an Affymetrix Transcriptomic approach the transcriptome of sciatic nerves and roots of P60 FASN mutant mice, comparing to control mice.
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| Overall design |
N = 3 sample per condition, 2 tissues analyzed: sciatic nerve and roots, 2 genotypes: DhhCre+ Fasn lox/lox (mutant) and DhhCre- Fasn lox/lox (control)
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| Contributor(s) |
Montani L, Suter U |
| Citation(s) |
29434029 |
| |
| Submission date |
Jul 27, 2015 |
| Last update date |
Aug 06, 2018 |
| Contact name |
Laura Montani |
| Organization name |
IMHS - ETH Zürich
|
| Street address |
Otto Stern Weg 7
|
| City |
Zürich |
| State/province |
ZH |
| ZIP/Postal code |
8093 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL11180 |
[HT_MG-430_PM] Affymetrix HT MG-430 PM Array Plate |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA291057 |
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