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Status |
Public on Sep 13, 2016 |
Title |
Comparative expression analysis of carfilzomib-resistant and parental LP-1 human multiple myeloma cells |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
LP-1 cells were exposed to stepwise increasing concentrations of carfilzomib over a period of 18 weeks: cells adapted to growth in 4 nM carfilzomib by 4 weeks, in 6 nM in another 6 weeks and in 12 nM after a further 8 weeks. The resulting cell culture, denoted LP-1/Cfz, retained resistance to carfilzomib even when tested after removal of selective pressure for approximately 8 weeks.
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Overall design |
LP-1/Cfz cells were profiled for gene expression after 1 week of growth in the absence of carfilzomib together with parental LP-1 cells which had not been selected in the drug (triplicate samples).
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Contributor(s) |
Riz I, Hawley TS, Hawley RG |
Citation(s) |
27626179 |
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Submission date |
Feb 18, 2016 |
Last update date |
Mar 25, 2019 |
Contact name |
Robert Hawley |
Organization name |
George Washington University
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Department |
Anatomy and Regenerative Biology
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Street address |
2300 I Street NW, Suite 431
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City |
Washington |
State/province |
DC |
ZIP/Postal code |
20037 |
Country |
USA |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (6)
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Relations |
BioProject |
PRJNA312517 |