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| Status |
Public on Jun 10, 2016 |
| Title |
Liver tissue from liver specific Vps33b knockout (Vps33bfl/fl-AlfpCre) and control (Vps33bfl/fl) mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Liver tissue from Vps33b liver ko (Vps33bfl/fl-AlfpCre) mice is a model of liver disease associated with ARC syndrome, an autosomal recessive inherited metabolic disorder cause by mutations in VPS33B or VIPAS39.
ARC is a multisystem disorder, with liver and kidneys affected in particular. Defects in hepatocyte polarity have been identified.
Affymetrix arrays were used to characterise the changes in the liver transcriptome when Vps33b is not expressed.
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| Overall design |
Mouse liver tissue, 10 samples in total, 4 from control mice, 6 from ko mice.
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| Contributor(s) |
Gissen P, Hanley J, Blerida B, Straatman-Iwanowska A, Rogerson C, Anne-Marie L, Smith H |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| |
| Submission date |
Jun 09, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Paul Gissen |
| Organization name |
UCL
|
| Department |
LMCB
|
| Street address |
Gower Street
|
| City |
London |
| State/province |
London |
| ZIP/Postal code |
WC1E 6BT |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA325273 |
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