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| Status |
Public on Jun 23, 2020 |
| Title |
Resistance to Palbociclib involves multiple mechanisms amenable to targeting with drug holidays or drug switching to improve therapeutic outcome [Affymetrix] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
SNP genotyping by SNP array
|
| Summary |
Combination of CDK4/6 inhibitors and endocrine therapy has been shown to improve clinical outcome in advanced estrogen receptor-positive breast cancer. However, not all patients will benefit and relapse is inevitable making the identification of new therapeutic strategies/biomarkers of particular importance.
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| |
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| Overall design |
Affymetrix Genome-wide Human SNP Array 6.0 arrays were performed according to the manufacturer's directions on DNA extracted from the target cell lines using QIAamp DNA mini kit according to the manusfacturer’s instructions (Qiagen).
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| |
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| Contributor(s) |
Gao Q, Santos RR, Martin LA |
| Citation(s) |
32307447 |
| |
| Submission date |
May 17, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Alice Gao |
| E-mail(s) |
alice.gao@icr.ac.uk
|
| Organization name |
The Institute of Cancer Research
|
| Department |
Breast Cancer Now
|
| Lab |
Molecular Cell Biology
|
| Street address |
237 Fulham Road
|
| City |
London |
| State/province |
London |
| ZIP/Postal code |
SW3 6JB |
| Country |
United Kingdom |
| |
|
| Platforms (1) |
| GPL6801 |
[GenomeWideSNP_6] Affymetrix Genome-Wide Human SNP 6.0 Array |
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| Samples (8)
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| This SubSeries is part of SuperSeries: |
| GSE99003 |
Resistance to Palbociclib involves multiple mechanisms amenable to targeting with drug holidays or drug switching to improve therapeutic outcome |
|
| Relations |
| BioProject |
PRJNA386961 |
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