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| Status |
Public on Oct 06, 2017 |
| Title |
Genomic profiles of oxidative stress-induced renal cell carcinomas developed in Mutyh deficient mice |
| Organism |
Mus musculus |
| Experiment type |
Genome variation profiling by array
Genome variation profiling by genome tiling array
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| Summary |
Intraperitoneal administration of ferric nitrilotriacetate initiates Fenton reaction in the renal proximal tubules in rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatment. We performed high-resolution microarray comparative genomic hybridization to identify characteristics in the genomic profiles of oxidative stress-induced RCCs and simultaneously developed malignant lymphomas in the mice. The results highlighted a substantial difference in the predisposition to chromosomal changes between animal species.
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| Overall design |
The carcinogenesis protocol was performed for two groups of wild type mice and Mutyh deficient mice. Genomes of 4 renal cell carcinomas and 5 malignant lymphomas from the treated groups were profiled on Agilent 180K mouse genome CGH microarrays. Three spontaneous malignant lymphomas from the untreated control groups were also analyzed with the same Agilent CGH microarrays.
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| Contributor(s) |
Li G, Akatsuka S, Toyokuni S |
| Citation(s) |
29027306 |
| |
| Submission date |
Jun 01, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Shinya Toyokuni |
| E-mail(s) |
akatsuka@med.nagoya-u.ac.jp
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| Organization name |
Nagoya University
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| Department |
Pathology
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| Street address |
65 Tsuruma-Cho, Showa-Ku
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| City |
Nagoya |
| State/province |
Aichi |
| ZIP/Postal code |
466-8550 |
| Country |
Japan |
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| Platforms (1) |
| GPL10449 |
Agilent-027411 SurePrint G3 Mouse CGH Microarray 4x180K (Feature Number version) |
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| Samples (12)
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| Relations |
| BioProject |
PRJNA388755 |
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