GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE99535 Query DataSets for GSE99535
Status Public on Oct 06, 2017
Title Genomic profiles of oxidative stress-induced renal cell carcinomas developed in Mutyh deficient mice
Organism Mus musculus
Experiment type Genome variation profiling by array
Genome variation profiling by genome tiling array
Summary Intraperitoneal administration of ferric nitrilotriacetate initiates Fenton reaction in the renal proximal tubules in rodents that ultimately leads to a high incidence of renal cell carcinoma (RCC) after repeated treatment. We performed high-resolution microarray comparative genomic hybridization to identify characteristics in the genomic profiles of oxidative stress-induced RCCs and simultaneously developed malignant lymphomas in the mice. The results highlighted a substantial difference in the predisposition to chromosomal changes between animal species.
Overall design The carcinogenesis protocol was performed for two groups of wild type mice and Mutyh deficient mice. Genomes of 4 renal cell carcinomas and 5 malignant lymphomas from the treated groups were profiled on Agilent 180K mouse genome CGH microarrays. Three spontaneous malignant lymphomas from the untreated control groups were also analyzed with the same Agilent CGH microarrays.
Contributor(s) Li G, Akatsuka S, Toyokuni S
Citation(s) 29027306
Submission date Jun 01, 2017
Last update date Jul 25, 2021
Contact name Shinya Toyokuni
Organization name Nagoya University
Department Pathology
Street address 65 Tsuruma-Cho, Showa-Ku
City Nagoya
State/province Aichi
ZIP/Postal code 466-8550
Country Japan
Platforms (1)
GPL10449 Agilent-027411 SurePrint G3 Mouse CGH Microarray 4x180K (Feature Number version)
Samples (12)
GSM2645618 Renal cell carcinoma 1
GSM2645619 Renal cell carcinoma 2
GSM2645620 Renal cell carcinoma 3
BioProject PRJNA388755

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE99535_RAW.tar 609.1 Mb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap