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Nail disease

MedGen UID:
10171
•Concept ID:
C0027339
•
Disease or Syndrome
Synonym: Nail disorder
SNOMED CT: Nail disease (17790008); Disorder of nail (17790008)
 
Monarch Initiative: MONDO:0002884

Definition

A disease involving the nail. [from MONDO]

Professional guidelines

PubMed

Nail psoriasis and nail lichen planus: Updates on diagnosis and management.
Hwang JK, Grover C, Iorizzo M, Lebwohl MG, Piraccini BM, Rigopoulos DG, Lipner SR
J Am Acad Dermatol 2024 Mar;90(3):585-596. Epub 2023 Nov 24 doi: 10.1016/j.jaad.2023.11.024. PMID: 38007038
Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Biotin for the treatment of nail disease: what is the evidence?
Lipner SR, Scher RK
J Dermatolog Treat 2018 Jun;29(4):411-414. Epub 2017 Nov 9 doi: 10.1080/09546634.2017.1395799. PMID: 29057689

Recent clinical studies

Etiology

Management of nail psoriasis.
Thomas L, Azad J, Takwale A
Clin Exp Dermatol 2021 Jan;46(1):3-8. Epub 2020 Aug 2 doi: 10.1111/ced.14314. PMID: 32741010
Diagnosis using nail matrix.
Richert B, Caucanas M, André J
Dermatol Clin 2015 Apr;33(2):243-55. Epub 2015 Feb 21 doi: 10.1016/j.det.2014.12.005. PMID: 25828714
Scoring nail psoriasis.
Klaassen KM, van de Kerkhof PC, Bastiaens MT, Plusjé LG, Baran RL, Pasch MC
J Am Acad Dermatol 2014 Jun;70(6):1061-6. Epub 2014 Mar 31 doi: 10.1016/j.jaad.2014.02.010. PMID: 24698704
Drug-related nail disease.
Piraccini BM, Alessandrini A
Clin Dermatol 2013 Sep-Oct;31(5):618-26. doi: 10.1016/j.clindermatol.2013.06.013. PMID: 24079591
Understanding nail disorders.
Baran R, Kechijian P
Eur J Dermatol 2001 Mar-Apr;11(2):159-62. PMID: 11275819

Diagnosis

Nail psoriasis and nail lichen planus: Updates on diagnosis and management.
Hwang JK, Grover C, Iorizzo M, Lebwohl MG, Piraccini BM, Rigopoulos DG, Lipner SR
J Am Acad Dermatol 2024 Mar;90(3):585-596. Epub 2023 Nov 24 doi: 10.1016/j.jaad.2023.11.024. PMID: 38007038
Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Challenge of Nail Psoriasis: An Update Review.
Ji C, Wang H, Bao C, Zhang L, Ruan S, Zhang J, Gong T, Cheng B
Clin Rev Allergy Immunol 2021 Dec;61(3):377-402. Epub 2021 Sep 3 doi: 10.1007/s12016-021-08896-9. PMID: 34478047
The pathogenesis of psoriatic arthritis.
Veale DJ, Fearon U
Lancet 2018 Jun 2;391(10136):2273-2284. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)30830-4. PMID: 29893226
Psoriatic arthritis: state of the art review.
Coates LC, Helliwell PS
Clin Med (Lond) 2017 Feb;17(1):65-70. doi: 10.7861/clinmedicine.17-1-65. PMID: 28148584Free PMC Article

Therapy

Isolated nail lichen planus: An expert consensus on treatment of the classical form.
Iorizzo M, Tosti A, Starace M, Baran R, Daniel CR 3rd, Di Chiacchio N, Goettmann S, Grover C, Haneke E, Lipner SR, Rich P, Richert B, Rigopoulos D, Rubin AI, Zaiac M, Piraccini BM
J Am Acad Dermatol 2020 Dec;83(6):1717-1723. Epub 2020 Feb 26 doi: 10.1016/j.jaad.2020.02.056. PMID: 32112995
Psoriatic arthritis for dermatologists.
Gottlieb A, Merola JF
J Dermatolog Treat 2020 Nov;31(7):662-679. Epub 2019 May 7 doi: 10.1080/09546634.2019.1605142. PMID: 31014154
Photoonycholysis: new findings.
Baran R, Mascaro JM, Aguilera P
J Eur Acad Dermatol Venereol 2019 Jan;33(1):56-62. Epub 2018 Jul 20 doi: 10.1111/jdv.15151. PMID: 29953667
Biotin for the treatment of nail disease: what is the evidence?
Lipner SR, Scher RK
J Dermatolog Treat 2018 Jun;29(4):411-414. Epub 2017 Nov 9 doi: 10.1080/09546634.2017.1395799. PMID: 29057689
Onychomycosis.
Welsh O, Vera-Cabrera L, Welsh E
Clin Dermatol 2010 Mar 4;28(2):151-9. doi: 10.1016/j.clindermatol.2009.12.006. PMID: 20347657

Prognosis

Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
Disease burden and treatment challenges of psoriatic arthritis in Africa and the Middle East.
Bedaiwi M, Al-Homood IA, El-Garf A, Uthman I, Sunna N, Nassier R, Mohamed H, Al Saleh J
Rheumatol Int 2019 Aug;39(8):1321-1329. Epub 2019 May 27 doi: 10.1007/s00296-019-04319-3. PMID: 31134289
The pathogenesis of psoriatic arthritis.
Veale DJ, Fearon U
Lancet 2018 Jun 2;391(10136):2273-2284. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)30830-4. PMID: 29893226
The burden of nail psoriasis: an introduction.
Baran R
Dermatology 2010;221 Suppl 1:1-5. Epub 2010 Aug 9 doi: 10.1159/000316169. PMID: 20733309
Hutchinson's sign: a reappraisal.
Baran R, Kechijian P
J Am Acad Dermatol 1996 Jan;34(1):87-90. doi: 10.1016/s0190-9622(96)90839-7. PMID: 8543700

Clinical prediction guides

Nail psoriasis and nail lichen planus: Updates on diagnosis and management.
Hwang JK, Grover C, Iorizzo M, Lebwohl MG, Piraccini BM, Rigopoulos DG, Lipner SR
J Am Acad Dermatol 2024 Mar;90(3):585-596. Epub 2023 Nov 24 doi: 10.1016/j.jaad.2023.11.024. PMID: 38007038
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
Management of nail psoriasis.
Thomas L, Azad J, Takwale A
Clin Exp Dermatol 2021 Jan;46(1):3-8. Epub 2020 Aug 2 doi: 10.1111/ced.14314. PMID: 32741010
The pathogenesis of psoriatic arthritis.
Veale DJ, Fearon U
Lancet 2018 Jun 2;391(10136):2273-2284. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)30830-4. PMID: 29893226
Psoriatic arthritis: state of the art review.
Coates LC, Helliwell PS
Clin Med (Lond) 2017 Feb;17(1):65-70. doi: 10.7861/clinmedicine.17-1-65. PMID: 28148584Free PMC Article

Recent systematic reviews

Dermoscopic features of nail psoriasis: a systematic review.
Rachadi H, Chiheb S
Int J Dermatol 2024 Aug;63(8):1013-1019. Epub 2024 Mar 22 doi: 10.1111/ijd.17138. PMID: 38520074
Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology.
Ortner VK, Mandel VD, Bertugno S, Philipsen PA, Haedersdal M
Exp Dermatol 2022 Jun;31(6):828-840. Epub 2022 Apr 22 doi: 10.1111/exd.14572. PMID: 35353919Free PMC Article
Photodynamic therapy for onychomycosis: A systematic review.
Bhatta AK, Keyal U, Wang XL
Photodiagnosis Photodyn Ther 2016 Sep;15:228-35. Epub 2016 Jul 28 doi: 10.1016/j.pdpdt.2016.07.010. PMID: 27477248
Treatment recommendations for psoriatic arthritis.
Ritchlin CT, Kavanaugh A, Gladman DD, Mease PJ, Helliwell P, Boehncke WH, de Vlam K, Fiorentino D, Fitzgerald O, Gottlieb AB, McHugh NJ, Nash P, Qureshi AA, Soriano ER, Taylor WJ; Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
Ann Rheum Dis 2009 Sep;68(9):1387-94. Epub 2008 Oct 24 doi: 10.1136/ard.2008.094946. PMID: 18952643Free PMC Article
Therapies for psoriatic nail disease. A systematic review.
Cassell S, Kavanaugh AF
J Rheumatol 2006 Jul;33(7):1452-6. Epub 2006 May 15 PMID: 16724366

Supplemental Content

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