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Nail disease

MedGen UID:
10171
•Concept ID:
C0027339
•
Disease or Syndrome
Synonym: Nail disorder
SNOMED CT: Nail disease (17790008); Disorder of nail (17790008)
 
Monarch Initiative: MONDO:0002884

Definition

A disease involving the nail. [from MONDO]

Professional guidelines

PubMed

Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
Biotin for the treatment of nail disease: what is the evidence?
Lipner SR, Scher RK
J Dermatolog Treat 2018 Jun;29(4):411-414. Epub 2017 Nov 9 doi: 10.1080/09546634.2017.1395799. PMID: 29057689

Recent clinical studies

Etiology

Prevalence and Characteristics of Onychomycosis in Patients with Knee Osteoarthritis: A Single-centre Prospective Cross-sectional Study.
Cho S, Lee H, Hwang JY, Choi JS, Kim HJ, Kim TW, Kang SB
Acta Derm Venereol 2021 Aug 25;101(8):adv00526. doi: 10.2340/00015555-3895. PMID: 34405245Free PMC Article
International Treatment Recommendations Update: A Report from the GRAPPA 2016 Annual Meeting.
Coates LC, Chandran V, Ogdie A, O'Sullivan D, Brooke M, Steinkoenig I, Mease PJ, Ritchlin CT, Kavanaugh A
J Rheumatol 2017 May;44(5):684-685. doi: 10.3899/jrheum.170144. PMID: 28461525
Chronic paronychia treatment: Square flap technique.
Ferreira Vieira d'Almeida L, Papaiordanou F, Araújo Machado E, Loda G, Baran R, Nakamura R
J Am Acad Dermatol 2016 Aug;75(2):398-403. Epub 2016 Mar 4 doi: 10.1016/j.jaad.2016.02.1154. PMID: 26946988
Understanding nail disorders.
Baran R, Kechijian P
Eur J Dermatol 2001 Mar-Apr;11(2):159-62. PMID: 11275819
Fungal nail disease: a guide to good practice (report of a Working Group of the British Society for Medical Mycology).
Denning DW, Evans EG, Kibbler CC, Richardson MD, Roberts MM, Rogers TR, Warnock DW, Warren RE
BMJ 1995 Nov 11;311(7015):1277-81. doi: 10.1136/bmj.311.7015.1277. PMID: 7496239Free PMC Article

Diagnosis

Optimal diagnosis and management of common nail disorders.
Lee DK, Lipner SR
Ann Med 2022 Dec;54(1):694-712. doi: 10.1080/07853890.2022.2044511. PMID: 35238267Free PMC Article
Pathology of the Nail Unit.
Ruben BS
Dermatol Clin 2021 Apr;39(2):319-336. doi: 10.1016/j.det.2020.12.009. PMID: 33745643
Psoriatic arthritis: state of the art review.
Coates LC, Helliwell PS
Clin Med (Lond) 2017 Feb;17(1):65-70. doi: 10.7861/clinmedicine.17-1-65. PMID: 28148584Free PMC Article
Diagnosing onychomycosis.
Gupta AK, Ricci MJ
Dermatol Clin 2006 Jul;24(3):365-9. doi: 10.1016/j.det.2006.03.008. PMID: 16798434
Understanding nail disorders.
Baran R, Kechijian P
Eur J Dermatol 2001 Mar-Apr;11(2):159-62. PMID: 11275819

Therapy

Emerging drugs for the treatment of onychomycosis.
Gupta AK, Stec N
Expert Opin Emerg Drugs 2019 Dec;24(4):213-220. Epub 2019 Oct 31 doi: 10.1080/14728214.2019.1685493. PMID: 31652088
Photoonycholysis: new findings.
Baran R, Mascaro JM, Aguilera P
J Eur Acad Dermatol Venereol 2019 Jan;33(1):56-62. Epub 2018 Jul 20 doi: 10.1111/jdv.15151. PMID: 29953667
Matricectomy and nail ablation.
Baran R, Haneke E
Hand Clin 2002 Nov;18(4):693-6, viii; discussion 697. doi: 10.1016/s0749-0712(02)00038-0. PMID: 12516982
Nail fungal infections and treatment.
Baran R
Hand Clin 2002 Nov;18(4):625-8, vi; discussion 629. doi: 10.1016/s0749-0712(02)00037-9. PMID: 12516977
Photoonycholysis.
Baran R, Juhlin L
Photodermatol Photoimmunol Photomed 2002 Aug;18(4):202-7. doi: 10.1034/j.1600-0781.2002.00760.x. PMID: 12390677

Prognosis

Nail disorders to be kept in mind.
Arnal C, Richert B
Hand Surg Rehabil 2024 Apr;43S:101640. Epub 2024 Jan 10 doi: 10.1016/j.hansur.2024.101640. PMID: 38215878
The pathogenesis of psoriatic arthritis.
Veale DJ, Fearon U
Lancet 2018 Jun 2;391(10136):2273-2284. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)30830-4. PMID: 29893226
Onychomycosis in patients with nail psoriasis: a point to point discussion.
Rigopoulos D, Papanagiotou V, Daniel R 3rd, Piraccini BM
Mycoses 2017 Jan;60(1):6-10. Epub 2016 Aug 15 doi: 10.1111/myc.12542. PMID: 27523738
Psoriatic nail disease, a predictor of psoriatic arthritis.
Baran R, Sigurgeirsson B
Br J Dermatol 2014 Nov;171(5):935-6. doi: 10.1111/bjd.13398. PMID: 25409998
Hutchinson's sign: a reappraisal.
Baran R, Kechijian P
J Am Acad Dermatol 1996 Jan;34(1):87-90. doi: 10.1016/s0190-9622(96)90839-7. PMID: 8543700

Clinical prediction guides

Nail psoriasis and nail lichen planus: Updates on diagnosis and management.
Hwang JK, Grover C, Iorizzo M, Lebwohl MG, Piraccini BM, Rigopoulos DG, Lipner SR
J Am Acad Dermatol 2024 Mar;90(3):585-596. Epub 2023 Nov 24 doi: 10.1016/j.jaad.2023.11.024. PMID: 38007038
Nail Psoriasis: Diagnosis, Assessment, Treatment Options, and Unmet Clinical Needs.
Kaeley GS, Eder L, Aydin SZ, Rich P, Bakewell CJ
J Rheumatol 2021 Aug;48(8):1208-1220. Epub 2021 Feb 15 doi: 10.3899/jrheum.201471. PMID: 33589557
The pathogenesis of psoriatic arthritis.
Veale DJ, Fearon U
Lancet 2018 Jun 2;391(10136):2273-2284. Epub 2018 Jun 1 doi: 10.1016/S0140-6736(18)30830-4. PMID: 29893226
Psoriatic arthritis: state of the art review.
Coates LC, Helliwell PS
Clin Med (Lond) 2017 Feb;17(1):65-70. doi: 10.7861/clinmedicine.17-1-65. PMID: 28148584Free PMC Article
Photoonycholysis.
Baran R, Juhlin L
Photodermatol Photoimmunol Photomed 2002 Aug;18(4):202-7. doi: 10.1034/j.1600-0781.2002.00760.x. PMID: 12390677

Recent systematic reviews

Nail changes in pemphigus: a systematic review and meta-analysis.
Ng CX, Lau Xer Min N, Choi EC, Long V, Chandran NS
Int J Dermatol 2024 Oct;63(10):1308-1317. Epub 2024 Jun 17 doi: 10.1111/ijd.17257. PMID: 38887088
Dermoscopic features of nail psoriasis: a systematic review.
Rachadi H, Chiheb S
Int J Dermatol 2024 Aug;63(8):1013-1019. Epub 2024 Mar 22 doi: 10.1111/ijd.17138. PMID: 38520074
Imaging of the nail unit in psoriatic patients:A systematic scoping review of techniques and terminology.
Ortner VK, Mandel VD, Bertugno S, Philipsen PA, Haedersdal M
Exp Dermatol 2022 Jun;31(6):828-840. Epub 2022 Apr 22 doi: 10.1111/exd.14572. PMID: 35353919Free PMC Article
Case Report: Coral Reef Pathogen Aspergillus sydowii Causing Black Grain Mycetoma.
Vera-Cabrera L, Cardenas-de la Garza JA, Cuellar-Barboza A, Gallardo-Rocha A, Molina-Torres CA, Escalante-Fuentes W, Ocampo-Candiani J
Am J Trop Med Hyg 2021 Jan 4;104(3):871-873. doi: 10.4269/ajtmh.20-1352. PMID: 33399044Free PMC Article
Photodynamic therapy for onychomycosis: A systematic review.
Bhatta AK, Keyal U, Wang XL
Photodiagnosis Photodyn Ther 2016 Sep;15:228-35. Epub 2016 Jul 28 doi: 10.1016/j.pdpdt.2016.07.010. PMID: 27477248

Supplemental Content

Table of contents

    Clinical resources

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