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Trigeminal nerve disorder

MedGen UID:
101823
•Concept ID:
C0152177
•
Disease or Syndrome
Synonym: Trigeminal nerve disease
SNOMED CT: Trigeminal nerve disorder (64309007); Disorder of the fifth cranial nerve (64309007); Disorders of the fifth nerve (64309007); Disorders of the Vth cranial nerve (64309007)
 
Monarch Initiative: MONDO:0003543

Definition

A non-neoplastic or neoplastic disorder affecting the trigeminal nerve (fifth cranial nerve). [from NCI]

Professional guidelines

PubMed

Signs and symptoms, quality of life and psychosocial data in 1331 post-traumatic trigeminal neuropathy patients seen in two tertiary referral centres in two countries.
Van der Cruyssen F, Peeters F, Gill T, De Laat A, Jacobs R, Politis C, Renton T
J Oral Rehabil 2020 Oct;47(10):1212-1221. Epub 2020 Aug 2 doi: 10.1111/joor.13058. PMID: 32687637Free PMC Article

Recent clinical studies

Etiology

Signs and symptoms, quality of life and psychosocial data in 1331 post-traumatic trigeminal neuropathy patients seen in two tertiary referral centres in two countries.
Van der Cruyssen F, Peeters F, Gill T, De Laat A, Jacobs R, Politis C, Renton T
J Oral Rehabil 2020 Oct;47(10):1212-1221. Epub 2020 Aug 2 doi: 10.1111/joor.13058. PMID: 32687637Free PMC Article
The safety and efficacy of preoperative embolization of meningioma with N-butyl cyanoacrylate.
Ishihara H, Ishihara S, Niimi J, Neki H, Kakehi Y, Uemiya N, Kohyama S, Yamane F, Kato H, Suzuki T, Adachi J, Mishima K, Nishikawa R
Interv Neuroradiol 2015 Oct;21(5):624-30. Epub 2015 Jun 26 doi: 10.1177/1591019915590537. PMID: 26116646Free PMC Article
Cold-induced corneal edema in patients with trigeminal nerve dysfunction.
Baratz KH, Trocme SD, Bourne WM
Am J Ophthalmol 1991 Nov 15;112(5):548-56. doi: 10.1016/s0002-9394(14)76857-6. PMID: 1951593

Diagnosis

Trigeminal trophic syndrome in a pediatric patient with diffuse intrinsic pontine glioma.
Hoover E, Jay R, Witman P
Pediatr Dermatol 2023 Mar;40(2):345-348. Epub 2022 Nov 21 doi: 10.1111/pde.15164. PMID: 36411544
Signs and symptoms, quality of life and psychosocial data in 1331 post-traumatic trigeminal neuropathy patients seen in two tertiary referral centres in two countries.
Van der Cruyssen F, Peeters F, Gill T, De Laat A, Jacobs R, Politis C, Renton T
J Oral Rehabil 2020 Oct;47(10):1212-1221. Epub 2020 Aug 2 doi: 10.1111/joor.13058. PMID: 32687637Free PMC Article
Upbeat nystagmus is a useful sign in the regional diagnosis of trigeminal nerve disorder with multiple sclerosis.
Nakamagoe K, Tozaka N, Nohara S, Kawakami R, Yamada S, Koganezawa T, Tamaoka A
Mult Scler Relat Disord 2018 Jan;19:59-61. Epub 2017 Nov 9 doi: 10.1016/j.msard.2017.11.008. PMID: 29136526
Primary Malignant Lymphoma of the Trigeminal Nerve: Case Report and Literature Review.
Ogiwara T, Horiuchi T, Sekiguchi N, Kakizawa Y, Hongo K
World Neurosurg 2015 Aug;84(2):592.e3-7. Epub 2015 Mar 19 doi: 10.1016/j.wneu.2015.03.019. PMID: 25797078

Therapy

Zanubrutinib in patients with previously treated B-cell malignancies intolerant of previous Bruton tyrosine kinase inhibitors in the USA: a phase 2, open-label, single-arm study.
Shadman M, Flinn IW, Levy MY, Porter RF, Burke JM, Zafar SF, Misleh J, Kingsley EC, Yimer HA, Freeman B, Rao SS, Chaudhry A, Tumula PK, Gandhi MD, Manda S, Chen DY, By K, Xu L, Liu Y, Crescenzo R, Idoine A, Zhang X, Cohen A, Huang J, Sharman JP
Lancet Haematol 2023 Jan;10(1):e35-e45. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00320-9. PMID: 36400069
The safety and efficacy of preoperative embolization of meningioma with N-butyl cyanoacrylate.
Ishihara H, Ishihara S, Niimi J, Neki H, Kakehi Y, Uemiya N, Kohyama S, Yamane F, Kato H, Suzuki T, Adachi J, Mishima K, Nishikawa R
Interv Neuroradiol 2015 Oct;21(5):624-30. Epub 2015 Jun 26 doi: 10.1177/1591019915590537. PMID: 26116646Free PMC Article
Cold-induced corneal edema in patients with trigeminal nerve dysfunction.
Baratz KH, Trocme SD, Bourne WM
Am J Ophthalmol 1991 Nov 15;112(5):548-56. doi: 10.1016/s0002-9394(14)76857-6. PMID: 1951593

Prognosis

Signs and symptoms, quality of life and psychosocial data in 1331 post-traumatic trigeminal neuropathy patients seen in two tertiary referral centres in two countries.
Van der Cruyssen F, Peeters F, Gill T, De Laat A, Jacobs R, Politis C, Renton T
J Oral Rehabil 2020 Oct;47(10):1212-1221. Epub 2020 Aug 2 doi: 10.1111/joor.13058. PMID: 32687637Free PMC Article

Clinical prediction guides

Signs and symptoms, quality of life and psychosocial data in 1331 post-traumatic trigeminal neuropathy patients seen in two tertiary referral centres in two countries.
Van der Cruyssen F, Peeters F, Gill T, De Laat A, Jacobs R, Politis C, Renton T
J Oral Rehabil 2020 Oct;47(10):1212-1221. Epub 2020 Aug 2 doi: 10.1111/joor.13058. PMID: 32687637Free PMC Article
Upbeat nystagmus is a useful sign in the regional diagnosis of trigeminal nerve disorder with multiple sclerosis.
Nakamagoe K, Tozaka N, Nohara S, Kawakami R, Yamada S, Koganezawa T, Tamaoka A
Mult Scler Relat Disord 2018 Jan;19:59-61. Epub 2017 Nov 9 doi: 10.1016/j.msard.2017.11.008. PMID: 29136526
Primary Malignant Lymphoma of the Trigeminal Nerve: Case Report and Literature Review.
Ogiwara T, Horiuchi T, Sekiguchi N, Kakizawa Y, Hongo K
World Neurosurg 2015 Aug;84(2):592.e3-7. Epub 2015 Mar 19 doi: 10.1016/j.wneu.2015.03.019. PMID: 25797078

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