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Tongue cancer

MedGen UID:
102262
•Concept ID:
C0153349
•
Neoplastic Process
Synonyms: Cancer of the Tongue; Cancer of Tongue; Cancer, Tongue; Cancers, Tongue; Tongue Cancer; Tongue Cancers
SNOMED CT: CA - Cancer of tongue (363375006); Cancer of tongue (363375006); Malignant tumor of tongue (363375006)
 
Monarch Initiative: MONDO:0004631

Definition

A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas. [from NCI]

Professional guidelines

PubMed

Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Controversies in relation to neck management in N0 early oral tongue cancer.
Hanai N, Asakage T, Kiyota N, Homma A, Hayashi R
Jpn J Clin Oncol 2019 Apr 1;49(4):297-305. doi: 10.1093/jjco/hyy196. PMID: 30668761
Japanese Clinical Practice Guideline for Head and Neck Cancer.
Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T
Auris Nasus Larynx 2017 Aug;44(4):375-380. Epub 2017 Mar 18 doi: 10.1016/j.anl.2017.02.004. PMID: 28325607

Curated

NCCN, Head and Neck, 2.2022

Recent clinical studies

Etiology

Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Classification of tongue cancer resection and treatment algorithm.
Mannelli G, Arcuri F, Agostini T, Innocenti M, Raffaini M, Spinelli G
J Surg Oncol 2018 Apr;117(5):1092-1099. Epub 2018 Feb 12 doi: 10.1002/jso.24991. PMID: 29432642
Tongue cancer during pregnancy: Surgery and more, a multidisciplinary challenge.
Tagliabue M, Elrefaey SH, Peccatori F, Favia G, Navach V, Pignataro L, Capaccio P, Venturino M, Tredici S, Alterio D, Mosca F, Pugni L, Scarfone G, Cossu Rocca M, Calabrese L
Crit Rev Oncol Hematol 2016 Feb;98:1-11. Epub 2015 Oct 9 doi: 10.1016/j.critrevonc.2015.09.006. PMID: 26476748
Human papillomavirus and tonsillar and base of tongue cancer.
Ramqvist T, Grün N, Dalianis T
Viruses 2015 Mar 20;7(3):1332-43. doi: 10.3390/v7031332. PMID: 25803099Free PMC Article

Diagnosis

Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Deep learning model for tongue cancer diagnosis using endoscopic images.
Heo J, Lim JH, Lee HR, Jang JY, Shin YS, Kim D, Lim JY, Park YM, Koh YW, Ahn SH, Chung EJ, Lee DY, Seok J, Kim CH
Sci Rep 2022 Apr 15;12(1):6281. doi: 10.1038/s41598-022-10287-9. PMID: 35428854Free PMC Article
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Contemplating Resectability.
Shuman AG
Hastings Cent Rep 2017 Nov;47(6):3-4. doi: 10.1002/hast.777. PMID: 29171050

Therapy

Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Effects of flavonoids on tongue squamous cell carcinoma.
Gutiérrez-Venegas G, Sánchez-Carballido MA, Delmas Suárez C, Gómez-Mora JA, Bonneau N
Cell Biol Int 2020 Mar;44(3):686-720. Epub 2019 Dec 4 doi: 10.1002/cbin.11266. PMID: 31758641
Mechanisms correlated with chemotherapy resistance in tongue cancers.
Han G, Xu C, Yu D
J Cancer Res Ther 2018 Jan;14(1):1-5. doi: 10.4103/jcrt.JCRT_763_17. PMID: 29516950
Japanese Clinical Practice Guideline for Head and Neck Cancer.
Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T
Auris Nasus Larynx 2017 Aug;44(4):375-380. Epub 2017 Mar 18 doi: 10.1016/j.anl.2017.02.004. PMID: 28325607

Prognosis

Tongue cancer treatment and oncological outcomes: The role of glossectomy classification.
De Berardinis R, Tagliabue M, Belloni P, Gandini S, Scaglione D, Maffini F, Margherini S, Riccio S, Giugliano G, Bruschini R, Chu F, Ansarin M
Surg Oncol 2022 Jun;42:101751. Epub 2022 Apr 6 doi: 10.1016/j.suronc.2022.101751. PMID: 35447523
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Mechanisms correlated with chemotherapy resistance in tongue cancers.
Han G, Xu C, Yu D
J Cancer Res Ther 2018 Jan;14(1):1-5. doi: 10.4103/jcrt.JCRT_763_17. PMID: 29516950
Classification of tongue cancer resection and treatment algorithm.
Mannelli G, Arcuri F, Agostini T, Innocenti M, Raffaini M, Spinelli G
J Surg Oncol 2018 Apr;117(5):1092-1099. Epub 2018 Feb 12 doi: 10.1002/jso.24991. PMID: 29432642

Clinical prediction guides

Margin distance in oral tongue cancer surgery: A systematic review of survival and recurrence outcomes.
Spence RN, Efthymiou V, Goss D, Varvares MA
Oral Oncol 2023 Dec;147:106609. Epub 2023 Nov 8 doi: 10.1016/j.oraloncology.2023.106609. PMID: 37948894
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma.
Näsman A, Bersani C, Lindquist D, Du J, Ramqvist T, Dalianis T
Anticancer Res 2017 Oct;37(10):5319-5328. doi: 10.21873/anticanres.11958. PMID: 28982840
Human papillomavirus and tonsillar and base of tongue cancer.
Ramqvist T, Grün N, Dalianis T
Viruses 2015 Mar 20;7(3):1332-43. doi: 10.3390/v7031332. PMID: 25803099Free PMC Article
Biomarkers in tongue cancer: understanding the molecular basis and their clinical implications.
Zheng M, Li L, Tang YL, Liang XH
Postgrad Med J 2010 May;86(1015):292-8. Epub 2010 Apr 14 doi: 10.1136/pgmj.2009.086504. PMID: 20392934

Recent systematic reviews

Margin distance in oral tongue cancer surgery: A systematic review of survival and recurrence outcomes.
Spence RN, Efthymiou V, Goss D, Varvares MA
Oral Oncol 2023 Dec;147:106609. Epub 2023 Nov 8 doi: 10.1016/j.oraloncology.2023.106609. PMID: 37948894
Functional considerations between flap and non-flap reconstruction in oral tongue cancer: A systematic review.
Cortina LE, Moverman DJ, Zhao Y, Goss D, Zenga J, Puram SV, Varvares MA
Oral Oncol 2023 Dec;147:106596. Epub 2023 Oct 13 doi: 10.1016/j.oraloncology.2023.106596. PMID: 37839153
Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis.
Elseragy A, Bello IO, Wahab A, Coletta RD, Mäkitie AA, Leivo I, Almangush A, Salo T
Head Neck 2022 Jun;44(6):1481-1491. Epub 2022 Feb 28 doi: 10.1002/hed.27022. PMID: 35229398Free PMC Article
Age and risk of recurrence in oral tongue squamous cell carcinoma: Systematic review.
Lenze NR, Farquhar DR, Dorismond C, Sheth S, Zevallos JP, Blumberg J, Lumley C, Patel S, Hackman T, Weissler MC, Yarbrough WG, Olshan AF, Zanation AM
Head Neck 2020 Dec;42(12):3755-3768. Epub 2020 Sep 11 doi: 10.1002/hed.26464. PMID: 32914472
Speech and swallowing following tongue cancer surgery and free flap reconstruction--a systematic review.
Lam L, Samman N
Oral Oncol 2013 Jun;49(6):507-24. Epub 2013 Apr 6 doi: 10.1016/j.oraloncology.2013.03.001. PMID: 23566773

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