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Tongue cancer

MedGen UID:
102262
•Concept ID:
C0153349
•
Neoplastic Process
Synonyms: Cancer of the Tongue; Cancer of Tongue; Cancer, Tongue; Cancers, Tongue; Tongue Cancer; Tongue Cancers
SNOMED CT: CA - Cancer of tongue (363375006); Cancer of tongue (363375006); Malignant tumor of tongue (363375006)
 
Monarch Initiative: MONDO:0004631

Definition

A malignant neoplasm affecting the tongue. The vast majority of cases are carcinomas. [from NCI]

Professional guidelines

PubMed

Improving oral squamous cell carcinoma diagnosis and treatment with fluorescence molecular imaging.
Fu J, Alhaskawi A, Dong Y, Jin F, Chen J, Zou X, Zhou H, Liu Z, Abdalbary SA, Lu H
Photodiagnosis Photodyn Ther 2023 Dec;44:103760. Epub 2023 Aug 25 doi: 10.1016/j.pdpdt.2023.103760. PMID: 37634605
Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Japanese Clinical Practice Guideline for Head and Neck Cancer.
Nibu KI, Hayashi R, Asakage T, Ojiri H, Kimata Y, Kodaira T, Nagao T, Nakashima T, Fujii T, Fujii H, Homma A, Matsuura K, Monden N, Beppu T, Hanai N, Kirita T, Kamei Y, Otsuki N, Kiyota N, Zenda S, Omura K, Omori K, Akimoto T, Kawabata K, Kishimoto S, Kitano H, Tohnai I, Nakatsuka T
Auris Nasus Larynx 2017 Aug;44(4):375-380. Epub 2017 Mar 18 doi: 10.1016/j.anl.2017.02.004. PMID: 28325607

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals.
Tota JE, Engels EA, Lingen MW, Agrawal N, Kerr AR, Zumsteg ZS, Cheung LC, Katki HA, Abnet CC, Chaturvedi AK
J Clin Oncol 2024 May 20;42(15):1745-1753. Epub 2023 Nov 30 doi: 10.1200/JCO.23.00729. PMID: 38033283Free PMC Article
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Tongue cancer during pregnancy: Surgery and more, a multidisciplinary challenge.
Tagliabue M, Elrefaey SH, Peccatori F, Favia G, Navach V, Pignataro L, Capaccio P, Venturino M, Tredici S, Alterio D, Mosca F, Pugni L, Scarfone G, Cossu Rocca M, Calabrese L
Crit Rev Oncol Hematol 2016 Feb;98:1-11. Epub 2015 Oct 9 doi: 10.1016/j.critrevonc.2015.09.006. PMID: 26476748
Human papillomavirus and tonsillar and base of tongue cancer.
Ramqvist T, Grün N, Dalianis T
Viruses 2015 Mar 20;7(3):1332-43. doi: 10.3390/v7031332. PMID: 25803099Free PMC Article

Diagnosis

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals.
Tota JE, Engels EA, Lingen MW, Agrawal N, Kerr AR, Zumsteg ZS, Cheung LC, Katki HA, Abnet CC, Chaturvedi AK
J Clin Oncol 2024 May 20;42(15):1745-1753. Epub 2023 Nov 30 doi: 10.1200/JCO.23.00729. PMID: 38033283Free PMC Article
Orofacial Pain: Molecular Mechanisms, Diagnosis, and Treatment 2021.
Matsuka Y
Int J Mol Sci 2022 Apr 27;23(9) doi: 10.3390/ijms23094826. PMID: 35563219Free PMC Article
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Contemplating Resectability.
Shuman AG
Hastings Cent Rep 2017 Nov;47(6):3-4. doi: 10.1002/hast.777. PMID: 29171050

Therapy

Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Brachytherapy and osteoradionecrosis in patients with base of tongue cancer.
Danielsson D, Hagel E, Dybeck-Udd S, Sjöström M, Kjeller G, Bengtsson M, Abtahi J, von Beckerath M, Thor A, Halle M, Friesland S, Mercke C, Westermark A, Högmo A, Munck-Wikland E
Acta Otolaryngol 2023 Jan;143(1):77-84. Epub 2023 Jan 3 doi: 10.1080/00016489.2022.2161627. PMID: 36595465
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
Genetically Determined Chronic Low-Grade Inflammation and Hundreds of Health Outcomes in the UK Biobank and the FinnGen Population: A Phenome-Wide Mendelian Randomization Study.
Si S, Li J, Tewara MA, Xue F
Front Immunol 2021;12:720876. Epub 2021 Jul 27 doi: 10.3389/fimmu.2021.720876. PMID: 34386016Free PMC Article
Mechanisms correlated with chemotherapy resistance in tongue cancers.
Han G, Xu C, Yu D
J Cancer Res Ther 2018 Jan;14(1):1-5. doi: 10.4103/jcrt.JCRT_763_17. PMID: 29516950

Prognosis

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals.
Tota JE, Engels EA, Lingen MW, Agrawal N, Kerr AR, Zumsteg ZS, Cheung LC, Katki HA, Abnet CC, Chaturvedi AK
J Clin Oncol 2024 May 20;42(15):1745-1753. Epub 2023 Nov 30 doi: 10.1200/JCO.23.00729. PMID: 38033283Free PMC Article
Three-dimensional assessment of tongue cancer prognosis by preoperative MRI.
Li C, Zhu L, Guo Y, Ji T, Ren Z
Oral Dis 2023 Jul;29(5):2006-2011. Epub 2022 Apr 25 doi: 10.1111/odi.14212. PMID: 35426211
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial.
Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Bly A, Gray P, Harjula K, Heikkilä K, Hokkanen M, Karttunen H, Kuortti M, Nieminen P, Nummela M, Paavonen J, Palmroth J, Petäjä T, Pukkala E, Soderlund-Strand A, Veivo U, Dillner J
BMJ Open 2021 Dec 30;11(12):e050669. doi: 10.1136/bmjopen-2021-050669. PMID: 35149535Free PMC Article
PRPF19 promotes tongue cancer growth and chemoradiotherapy resistance.
He Y, Huang C, Cai K, Liu P, Chen X, Xu YI, Ming Z, Liu Q, Xie Q, Xia X, Sun Y, Luo J, Wei R
Acta Biochim Biophys Sin (Shanghai) 2021 Jul 5;53(7):893-902. doi: 10.1093/abbs/gmab059. PMID: 33954334
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342

Clinical prediction guides

Inflammatory Tongue Conditions and Risk of Oral Tongue Cancer Among the US Elderly Individuals.
Tota JE, Engels EA, Lingen MW, Agrawal N, Kerr AR, Zumsteg ZS, Cheung LC, Katki HA, Abnet CC, Chaturvedi AK
J Clin Oncol 2024 May 20;42(15):1745-1753. Epub 2023 Nov 30 doi: 10.1200/JCO.23.00729. PMID: 38033283Free PMC Article
Margin distance in oral tongue cancer surgery: A systematic review of survival and recurrence outcomes.
Spence RN, Efthymiou V, Goss D, Varvares MA
Oral Oncol 2023 Dec;147:106609. Epub 2023 Nov 8 doi: 10.1016/j.oraloncology.2023.106609. PMID: 37948894
Compartmental tongue surgery for intermediate-advanced squamous cell carcinoma: A multicentric study.
Calabrese L, Tagliabue M, Grammatica A, De Berardinis R, Corso F, Gazzini L, Abousiam M, Fazio E, Mattavelli D, Fontanella W, Giannini L, Bresciani L, Bruschini R, Gandini S, Piazza C, Ansarin M
Head Neck 2023 Nov;45(11):2862-2873. Epub 2023 Sep 20 doi: 10.1002/hed.27517. PMID: 37727894
Global patterns and trends in cancers of the lip, tongue and mouth.
Miranda-Filho A, Bray F
Oral Oncol 2020 Mar;102:104551. Epub 2020 Jan 25 doi: 10.1016/j.oraloncology.2019.104551. PMID: 31986342
Human papillomavirus and tonsillar and base of tongue cancer.
Ramqvist T, Grün N, Dalianis T
Viruses 2015 Mar 20;7(3):1332-43. doi: 10.3390/v7031332. PMID: 25803099Free PMC Article

Recent systematic reviews

Margin distance in oral tongue cancer surgery: A systematic review of survival and recurrence outcomes.
Spence RN, Efthymiou V, Goss D, Varvares MA
Oral Oncol 2023 Dec;147:106609. Epub 2023 Nov 8 doi: 10.1016/j.oraloncology.2023.106609. PMID: 37948894
Functional considerations between flap and non-flap reconstruction in oral tongue cancer: A systematic review.
Cortina LE, Moverman DJ, Zhao Y, Goss D, Zenga J, Puram SV, Varvares MA
Oral Oncol 2023 Dec;147:106596. Epub 2023 Oct 13 doi: 10.1016/j.oraloncology.2023.106596. PMID: 37839153
Tonsillectomy as Prevention of Tonsil and Base of Tongue Cancer: Systematic Review and Meta-analysis on the Immuno-Oncological Effect of One Among the Most Common Surgeries in the World.
Virgilio E, Bonfili D, Bettoni S, Vona L, Mercuri J, D'Agostino F, Baldinu M, Salvemini C, Montali F, Costi R
Anticancer Res 2023 Sep;43(9):3881-3889. doi: 10.21873/anticanres.16575. PMID: 37648322
Emerging histopathologic markers in early-stage oral tongue cancer: A systematic review and meta-analysis.
Elseragy A, Bello IO, Wahab A, Coletta RD, Mäkitie AA, Leivo I, Almangush A, Salo T
Head Neck 2022 Jun;44(6):1481-1491. Epub 2022 Feb 28 doi: 10.1002/hed.27022. PMID: 35229398Free PMC Article
Speech and swallowing following tongue cancer surgery and free flap reconstruction--a systematic review.
Lam L, Samman N
Oral Oncol 2013 Jun;49(6):507-24. Epub 2013 Apr 6 doi: 10.1016/j.oraloncology.2013.03.001. PMID: 23566773

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    Clinical resources

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Reviews

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