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Tongue carcinoma

MedGen UID:
154320
•Concept ID:
C0558353
•
Neoplastic Process
Synonyms: Cancer of the Tongue; Cancer of Tongue; Carcinoma of the Tongue; Carcinoma of Tongue; Tongue Cancer; Tongue Carcinoma; tongue carcinoma
SNOMED CT: Tongue carcinoma (269516007)
 
Monarch Initiative: MONDO:0850154

Definition

A malignant tumor arising from the epithelium that covers the tongue. The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas. [from NCI]

Professional guidelines

PubMed

Prognostic outcomes of treatment naïve oral tongue squamous cell carcinoma (OTSCC): a comprehensive analysis of 14 years.
Faisal M, Dhanani R, Ullah S, Bakar MA, Irfan N, Malik KI, Loya A, Boban EM, Hussain R, Jamshed A
Eur Arch Otorhinolaryngol 2021 Aug;278(8):3045-3053. Epub 2020 Nov 25 doi: 10.1007/s00405-020-06482-x. PMID: 33236214
Management of advanced carcinoma of the base of tongue.
Karatzanis AD, Psychogios G, Mantsopoulos K, Zenk J, Velegrakis GA, Waldfahrer F, Iro H
J Surg Oncol 2012 Nov;106(6):713-8. Epub 2012 Apr 24 doi: 10.1002/jso.23135. PMID: 22532105
Surgery and postoperative radiotherapy a valid treatment for advanced oropharyngeal carcinoma.
Lybak S, Liavaag PG, Monge OR, Olofsson J
Eur Arch Otorhinolaryngol 2011 Mar;268(3):449-56. Epub 2010 Aug 28 doi: 10.1007/s00405-010-1344-6. PMID: 20803151Free PMC Article

Recent clinical studies

Etiology

Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Tongue carcinoma in young adults: a review of the literature.
Paderno A, Morello R, Piazza C
Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180. doi: 10.14639/0392-100X-1932. PMID: 29984792Free PMC Article
Carcinoma Tongue--Clinicopathological Presentation.
Majumder KR, Karmakar R, Alam MM, Rahman T
Mymensingh Med J 2015 Oct;24(4):787-93. PMID: 26620021
Ultrasonic partial glossectomy.
Pons Y, Gauthier J, Clément P, Conessa C
Head Neck Oncol 2009 Jun 24;1:21. doi: 10.1186/1758-3284-1-21. PMID: 19552821Free PMC Article
Total glossectomy.
Razack MS, Sako K, Bakamjian VY, Shedd DP
Am J Surg 1983 Oct;146(4):509-11. doi: 10.1016/0002-9610(83)90242-8. PMID: 6625097

Diagnosis

Preoperative MRI for oral tongue squamous cell carcinoma: timing and correlation to histopathology.
Rozendorn N, Greenberg G, Madgar O, Gluck I, Vered M, Alon E, Dobriyan A
Int J Oral Maxillofac Surg 2023 Mar;52(3):291-295. Epub 2022 Aug 8 doi: 10.1016/j.ijom.2022.07.003. PMID: 35953345
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Prognostic Role of Tumor-Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma.
Hori Y, Kubota A, Yokose T, Furukawa M, Matsushita T, Katsumata N, Oridate N
Laryngoscope 2021 Nov;131(11):2512-2518. Epub 2021 May 6 doi: 10.1002/lary.29589. PMID: 33955550Free PMC Article
Diagnosis System for Swallowing and Peristalsis Function for Artificial Tongue and Esophagus Development.
Yambe T, Shiraishi Y, Inoue Y, Yamada A
Annu Int Conf IEEE Eng Med Biol Soc 2020 Jul;2020:5128-5131. doi: 10.1109/EMBC44109.2020.9176039. PMID: 33019140
Bcl-xL overexpression and its association with the progress of tongue carcinoma.
Zhang K, Jiao K, Xing Z, Zhang L, Yang J, Xie X, Yang L
Int J Clin Exp Pathol 2014;7(11):7360-77. Epub 2014 Oct 15 PMID: 25550772Free PMC Article

Therapy

The role of electrochemotherapy with intratumoral bleomycin for early tongue carcinoma.
Zimmermann CE, Faesser HA, Gassling V, Wiltfang J
Acta Otolaryngol 2021 Apr;141(4):424-431. Epub 2021 Feb 16 doi: 10.1080/00016489.2020.1871511. PMID: 33591860
Mutational signatures and the genomic landscape of betel quid chewing-associated tongue carcinoma.
Zhang W, Wang M, Wu Q, Zhu Q, Jiao Y, Zhu Y, Yang B, Ni S, Yu J, Sun H, Zeng YX
Cancer Med 2019 Feb;8(2):701-711. Epub 2019 Jan 22 doi: 10.1002/cam4.1888. PMID: 30672146Free PMC Article
Sam68 reduces cisplatin-induced apoptosis in tongue carcinoma.
Chen S, Li H, Zhuang S, Zhang J, Gao F, Wang X, Chen W, Song M
J Exp Clin Cancer Res 2016 Jul 29;35(1):123. doi: 10.1186/s13046-016-0390-3. PMID: 27473117Free PMC Article
Carcinoma Tongue--Clinicopathological Presentation.
Majumder KR, Karmakar R, Alam MM, Rahman T
Mymensingh Med J 2015 Oct;24(4):787-93. PMID: 26620021
Ultrasonic partial glossectomy.
Pons Y, Gauthier J, Clément P, Conessa C
Head Neck Oncol 2009 Jun 24;1:21. doi: 10.1186/1758-3284-1-21. PMID: 19552821Free PMC Article

Prognosis

Pattern and localization of perineural invasion predict poor survival in oral tongue carcinoma.
Caponio VCA, Troiano G, Togni L, Zhurakivska K, Santarelli A, Laino L, Rubini C, Lo Muzio L, Mascitti M
Oral Dis 2023 Mar;29(2):411-422. Epub 2021 May 30 doi: 10.1111/odi.13900. PMID: 33964054
Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Prognostic Role of Tumor-Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma.
Hori Y, Kubota A, Yokose T, Furukawa M, Matsushita T, Katsumata N, Oridate N
Laryngoscope 2021 Nov;131(11):2512-2518. Epub 2021 May 6 doi: 10.1002/lary.29589. PMID: 33955550Free PMC Article
Tongue carcinoma in young adults: a review of the literature.
Paderno A, Morello R, Piazza C
Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180. doi: 10.14639/0392-100X-1932. PMID: 29984792Free PMC Article
Total glossectomy.
Razack MS, Sako K, Bakamjian VY, Shedd DP
Am J Surg 1983 Oct;146(4):509-11. doi: 10.1016/0002-9610(83)90242-8. PMID: 6625097

Clinical prediction guides

Squamous cell carcinoma of the tongue: subtypes and morphological features affecting prognosis.
Matsuo K, Akiba J, Kusukawa J, Yano H
Am J Physiol Cell Physiol 2022 Dec 1;323(6):C1611-C1623. Epub 2022 Oct 17 doi: 10.1152/ajpcell.00098.2022. PMID: 36252129
Prognostic Role of Tumor-Infiltrating Lymphocytes and Tumor Budding in Early Oral Tongue Carcinoma.
Hori Y, Kubota A, Yokose T, Furukawa M, Matsushita T, Katsumata N, Oridate N
Laryngoscope 2021 Nov;131(11):2512-2518. Epub 2021 May 6 doi: 10.1002/lary.29589. PMID: 33955550Free PMC Article
High expression of Notch2 drives tongue squamous cell carcinoma carcinogenesis.
Gan RH, Lin LS, Zheng DP, Zhao Y, Ding LC, Zheng DL, Lu YG
Exp Cell Res 2021 Feb 1;399(1):112452. Epub 2020 Dec 28 doi: 10.1016/j.yexcr.2020.112452. PMID: 33382997
Tongue carcinoma in young adults: a review of the literature.
Paderno A, Morello R, Piazza C
Acta Otorhinolaryngol Ital 2018 Jun;38(3):175-180. doi: 10.14639/0392-100X-1932. PMID: 29984792Free PMC Article
Carcinoma Tongue--Clinicopathological Presentation.
Majumder KR, Karmakar R, Alam MM, Rahman T
Mymensingh Med J 2015 Oct;24(4):787-93. PMID: 26620021

Recent systematic reviews

Elective node dissection versus observation for management of patients with early-stage cT1/T2N0 tongue carcinoma: A systematic review and meta-analysis of prospective studies.
Alsini AY, Alsubaie HM, Marzouki HZ, Abu-Zaid A, Al-Qahtani K
Clin Otolaryngol 2021 Jul;46(4):720-728. Epub 2021 May 6 doi: 10.1111/coa.13781. PMID: 33840160
Level IV neck dissection as an elective treatment for oral tongue carcinoma-a systematic review and meta-analysis.
Weisz Shabtay N, Ronen O
Oral Surg Oral Med Oral Pathol Oral Radiol 2020 Oct;130(4):363-372. Epub 2020 Jun 13 doi: 10.1016/j.oooo.2020.04.810. PMID: 32540318
Utility of intraoral ultrasound in managing oral tongue squamous cell carcinoma: Systematic review.
Tarabichi O, Bulbul MG, Kanumuri VV, Faquin WC, Juliano AF, Cunnane ME, Varvares MA
Laryngoscope 2019 Mar;129(3):662-670. Epub 2018 Aug 27 doi: 10.1002/lary.27403. PMID: 30151976

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