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Metastatic Malignant Neoplasm in the Skin

MedGen UID:
102287
Concept ID:
C0153687
Neoplastic Process
Synonyms: Cancer metastatic to skin; Cutaneous metastasis; Dermal metastasis; Malignant infiltration of skin; Metastases to Skin; Metastasis to skin; Metastasis to Skin; Metastatic malignant neoplasm of skin; Metastatic malignant neoplasm to skin; Metastatic Malignant Neoplasm to the Skin; Metastatic Neoplasm to the Skin; Metastatic Tumor to the Skin; Secondary cancer of skin; Secondary malignant neoplasm of skin; Skin Metastases; Skin Metastasis; Skin secondaries
SNOMED CT: Secondary malignant neoplasm of skin (94579000); Metastatic malignant neoplasm to skin (94579000); Cancer metastatic to skin (94579000); Metastatic malignant neoplasm of skin (94579000); Dermal metastasis (94579000); Cutaneous metastasis (94579000); Malignant infiltration of skin (94579000); Skin secondaries (94579000); Secondary cancer of skin (94579000); Metastasis to skin (94579000)

Definition

The spread of a malignant neoplasm to the skin. This may be from a primary skin malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Skin

Professional guidelines

PubMed

Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085
Davis LE, Shalin SC, Tackett AJ
Cancer Biol Ther 2019;20(11):1366-1379. Epub 2019 Aug 1 doi: 10.1080/15384047.2019.1640032. PMID: 31366280Free PMC Article
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208

Recent clinical studies

Etiology

Perez M, Abisaad JA, Rojas KD, Marchetti MA, Jaimes N
J Am Acad Dermatol 2022 Aug;87(2):255-268. Epub 2022 Feb 14 doi: 10.1016/j.jaad.2021.12.066. PMID: 35176397
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Turner N, Ware O, Bosenberg M
Clin Exp Metastasis 2018 Aug;35(5-6):379-391. Epub 2018 May 2 doi: 10.1007/s10585-018-9893-y. PMID: 29722002
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Diagnosis

Rojas KD, Perez ME, Marchetti MA, Nichols AJ, Penedo FJ, Jaimes N
J Am Acad Dermatol 2022 Aug;87(2):271-288. Epub 2022 Feb 14 doi: 10.1016/j.jaad.2022.01.053. PMID: 35176398
Ickrath F, Stoevesandt J, Schulmeyer L, Glatzel C, Goebeler M, Kerstan A
J Dtsch Dermatol Ges 2021 Jul;19(7):973-982. Epub 2021 May 7 doi: 10.1111/ddg.14447. PMID: 33960613
Khalil J, Kurban M, Abbas O
Int J Dermatol 2021 Feb;60(2):159-165. Epub 2020 Sep 2 doi: 10.1111/ijd.15165. PMID: 32880923
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194

Therapy

Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Ickrath F, Stoevesandt J, Schulmeyer L, Glatzel C, Goebeler M, Kerstan A
J Dtsch Dermatol Ges 2021 Jul;19(7):973-982. Epub 2021 May 7 doi: 10.1111/ddg.14447. PMID: 33960613
Rebecca VW, Somasundaram R, Herlyn M
Nat Commun 2020 Jun 5;11(1):2858. doi: 10.1038/s41467-020-15546-9. PMID: 32504051Free PMC Article
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Concetta Fargnoli M, Forsea AM, Frenard C, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NWJ, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:83-102. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.008. PMID: 32113942
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348

Prognosis

Rindler K, Bauer WM, Jonak C, Wielscher M, Shaw LE, Rojahn TB, Thaler FM, Porkert S, Simonitsch-Klupp I, Weninger W, Mayerhoefer ME, Farlik M, Brunner PM
Front Immunol 2021;12:666935. Epub 2021 Apr 21 doi: 10.3389/fimmu.2021.666935. PMID: 33968070Free PMC Article
Strickley JD, Jenson AB, Jung JY
Hematol Oncol Clin North Am 2019 Feb;33(1):173-197. doi: 10.1016/j.hoc.2018.08.008. PMID: 30497674
Turner N, Ware O, Bosenberg M
Clin Exp Metastasis 2018 Aug;35(5-6):379-391. Epub 2018 May 2 doi: 10.1007/s10585-018-9893-y. PMID: 29722002
Elder DE
Pathology 2016 Feb;48(2):147-54. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.002. PMID: 27020387
Elder DE
Arch Pathol Lab Med 2011 Mar;135(3):342-6. doi: 10.5858/2009-0479-RA.1. PMID: 21366458

Clinical prediction guides

Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Lezcano C, Pulitzer M, Moy AP, Hollmann TJ, Jungbluth AA, Busam KJ
Am J Surg Pathol 2020 Apr;44(4):503-508. doi: 10.1097/PAS.0000000000001393. PMID: 31633488Free PMC Article
De Souza LM, Robertson BM, Robertson GP
Cancer Lett 2017 Apr 28;392:60-70. Epub 2017 Feb 2 doi: 10.1016/j.canlet.2017.01.023. PMID: 28163189
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Pinkus H
Mod Probl Paediatr 1976 Oct 20-23;20:50-7. PMID: 1032522

Recent systematic reviews

Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Alonso-Belmonte C, Montero-Vilchez T, Arias-Santiago S, Buendía-Eisman A
Actas Dermosifiliogr 2022 Sep;113(8):781-791. Epub 2022 May 5 doi: 10.1016/j.ad.2022.04.015. PMID: 35526566
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Seth R, Messersmith H, Kaur V, Kirkwood JM, Kudchadkar R, McQuade JL, Provenzano A, Swami U, Weber J, Alluri KC, Agarwala S, Ascierto PA, Atkins MB, Davis N, Ernstoff MS, Faries MB, Gold JS, Guild S, Gyorki DE, Khushalani NI, Meyers MO, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Tsai KK, van Akkooi A, Funchain P
J Clin Oncol 2020 Nov 20;38(33):3947-3970. Epub 2020 Mar 31 doi: 10.1200/JCO.20.00198. PMID: 32228358
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

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