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Metastatic Malignant Neoplasm in the Skin

MedGen UID:
102287
•Concept ID:
C0153687
•
Neoplastic Process
Synonyms: Cancer metastatic to skin; Cutaneous metastasis; Dermal metastasis; Malignant infiltration of skin; Metastases to Skin; Metastasis to skin; Metastasis to Skin; Metastatic malignant neoplasm of skin; Metastatic malignant neoplasm to skin; Metastatic Malignant Neoplasm to the Skin; Metastatic Neoplasm to the Skin; Metastatic Tumor to the Skin; Secondary cancer of skin; Secondary malignant neoplasm of skin; Skin Metastases; Skin Metastasis; Skin secondaries
SNOMED CT: Secondary malignant neoplasm of skin (94579000); Metastatic malignant neoplasm to skin (94579000); Cancer metastatic to skin (94579000); Metastatic malignant neoplasm of skin (94579000); Dermal metastasis (94579000); Cutaneous metastasis (94579000); Malignant infiltration of skin (94579000); Skin secondaries (94579000); Secondary cancer of skin (94579000); Metastasis to skin (94579000)

Definition

The spread of a malignant neoplasm to the skin. This may be from a primary skin malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Skin

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023.
Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E
Eur J Cancer 2023 Oct;192:113254. Epub 2023 Jul 28 doi: 10.1016/j.ejca.2023.113254. PMID: 37604067
European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085
Current state of melanoma diagnosis and treatment.
Davis LE, Shalin SC, Tackett AJ
Cancer Biol Ther 2019;20(11):1366-1379. Epub 2019 Aug 1 doi: 10.1080/15384047.2019.1640032. PMID: 31366280Free PMC Article

Recent clinical studies

Etiology

Skin cancer: Primary, secondary, and tertiary prevention. Part I.
Perez M, Abisaad JA, Rojas KD, Marchetti MA, Jaimes N
J Am Acad Dermatol 2022 Aug;87(2):255-268. Epub 2022 Feb 14 doi: 10.1016/j.jaad.2021.12.066. PMID: 35176397
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Melanocytic nevi.
Hauschild A, Egberts F, Garbe C, Bauer J, Grabbe S, Hamm H, Kerl H, Reusch M, Rompel R, Schlaeger M; expert group "Melanocytic nevi"
J Dtsch Dermatol Ges 2011 Sep;9(9):723-34. Epub 2011 Jul 15 doi: 10.1111/j.1610-0387.2011.07741.x. PMID: 21762380

Diagnosis

Skin cancer: Primary, secondary, and tertiary prevention. Part II.
Rojas KD, Perez ME, Marchetti MA, Nichols AJ, Penedo FJ, Jaimes N
J Am Acad Dermatol 2022 Aug;87(2):271-288. Epub 2022 Feb 14 doi: 10.1016/j.jaad.2022.01.053. PMID: 35176398
Imaging in Cutaneous Melanoma: Which Test to Order and When?
Patel V, Su-Velez BM, Hannabass K, St John MA
Laryngoscope 2021 Dec;131(12):2636-2638. Epub 2021 Feb 19 doi: 10.1002/lary.29460. PMID: 33605438
Inflammatory Myositis-Secondary to SLE.
Ravi SV, Selvakumar CJ, Sacrates M, Shobhana, Mahesh A
J Assoc Physicians India 2019 Aug;67(8):11-12. PMID: 31562728
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Malignant proliferating angioendotheliomatosis.
Kauh YC, McFarland JP, Carnabuci GG, Luscombe HA
Arch Dermatol 1980 Jul;116(7):803-6. PMID: 7396545

Therapy

Pre-clinical modeling of cutaneous melanoma.
Rebecca VW, Somasundaram R, Herlyn M
Nat Commun 2020 Jun 5;11(1):2858. doi: 10.1038/s41467-020-15546-9. PMID: 32504051Free PMC Article
Management of Locoregionally Advanced Melanoma.
Pointer DT Jr, Zager JS
Surg Clin North Am 2020 Feb;100(1):109-125. Epub 2019 Oct 28 doi: 10.1016/j.suc.2019.09.003. PMID: 31753106
RF-Scalp cooling.
Moreno-Arrones OM, Saceda-Corralo D, Vañó-Galván S
Actas Dermosifiliogr 2017 Dec;108(10):945-946. Epub 2017 Jul 1 doi: 10.1016/j.ad.2017.04.014. PMID: 28676145
Advances in therapy for melanoma brain metastases.
Flanigan JC, Jilaveanu LB, Chiang VL, Kluger HM
Clin Dermatol 2013 May-Jun;31(3):264-81. doi: 10.1016/j.clindermatol.2012.08.008. PMID: 23608446
Melanoma and immunotherapy.
Eggermont AM, Schadendorf D
Hematol Oncol Clin North Am 2009 Jun;23(3):547-64, ix-x. doi: 10.1016/j.hoc.2009.03.009. PMID: 19464602

Prognosis

In-transit melanoma metastases.
Di Altobrando A, Scarfì F, Misciali C, Patrizi A, Dika E
Int J Dermatol 2019 Jul;58(7):844-845. Epub 2019 Jan 8 doi: 10.1111/ijd.14377. PMID: 30620054
Cutaneous Metastasis.
Strickley JD, Jenson AB, Jung JY
Hematol Oncol Clin North Am 2019 Feb;33(1):173-197. doi: 10.1016/j.hoc.2018.08.008. PMID: 30497674
Chordoma cutis.
Rubin AI, Bagel J, Niedt G
J Am Acad Dermatol 2005 May;52(5 Suppl 1):S105-8. doi: 10.1016/j.jaad.2004.07.055. PMID: 15858504
Secondary anetoderma involving a pilomatricoma.
Shames BS, Nassif A, Bailey CS, Saltzstein SL
Am J Dermatopathol 1994 Oct;16(5):557-60. doi: 10.1097/00000372-199410000-00020. PMID: 7802171
Malignant proliferating angioendotheliomatosis.
Kauh YC, McFarland JP, Carnabuci GG, Luscombe HA
Arch Dermatol 1980 Jul;116(7):803-6. PMID: 7396545

Clinical prediction guides

Predictors and outcomes of cutaneous metastatic breast carcinoma: a retrospective, single-institution review.
Choo ZY, Xu AZ
Arch Dermatol Res 2023 Nov;315(9):2725-2728. Epub 2023 Jul 25 doi: 10.1007/s00403-023-02676-5. PMID: 37490055
Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.
Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Pathological assessment of resection specimens after neoadjuvant therapy for metastatic melanoma.
Tetzlaff MT, Messina JL, Stein JE, Xu X, Amaria RN, Blank CU, van de Wiel BA, Ferguson PM, Rawson RV, Ross MI, Spillane AJ, Gershenwald JE, Saw RPM, van Akkooi ACJ, van Houdt WJ, Mitchell TC, Menzies AM, Long GV, Wargo JA, Davies MA, Prieto VG, Taube JM, Scolyer RA
Ann Oncol 2018 Aug 1;29(8):1861-1868. doi: 10.1093/annonc/mdy226. PMID: 29945191Free PMC Article
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989
Paraneoplastic cicatricial pemphigoid.
Setterfield J, Shirlaw PJ, Lazarova Z, Bryant BM, Bhogal BS, Harman K, Challacombe SJ, Black MM
Br J Dermatol 1999 Jul;141(1):127-31. doi: 10.1046/j.1365-2133.1999.02933.x. PMID: 10417528

Recent systematic reviews

Systemic Therapy for Melanoma: ASCO Guideline Update.
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review.
Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Current State of Skin Cancer Prevention: A Systematic Review.
Alonso-Belmonte C, Montero-Vilchez T, Arias-Santiago S, Buendía-Eisman A
Actas Dermosifiliogr 2022 Sep;113(8):781-791. Epub 2022 May 5 doi: 10.1016/j.ad.2022.04.015. PMID: 35526566
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;2015(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

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