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Metastatic Malignant Neoplasm in the Skin

MedGen UID:
102287
•Concept ID:
C0153687
•
Neoplastic Process
Synonyms: Cancer metastatic to skin; Cutaneous metastasis; Dermal metastasis; Malignant infiltration of skin; Metastases to Skin; Metastasis to skin; Metastasis to Skin; Metastatic malignant neoplasm of skin; Metastatic malignant neoplasm to skin; Metastatic Malignant Neoplasm to the Skin; Metastatic Neoplasm to the Skin; Metastatic Tumor to the Skin; Secondary cancer of skin; Secondary malignant neoplasm of skin; Skin Metastases; Skin Metastasis; Skin secondaries
SNOMED CT: Secondary malignant neoplasm of skin (94579000); Metastatic malignant neoplasm to skin (94579000); Cancer metastatic to skin (94579000); Metastatic malignant neoplasm of skin (94579000); Dermal metastasis (94579000); Cutaneous metastasis (94579000); Malignant infiltration of skin (94579000); Skin secondaries (94579000); Secondary cancer of skin (94579000); Metastasis to skin (94579000)

Definition

The spread of a malignant neoplasm to the skin. This may be from a primary skin malignant neoplasm, or from a malignant neoplasm at a distant site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Skin

Professional guidelines

PubMed

European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics: Update 2022.
Garbe C, Amaral T, Peris K, Hauschild A, Arenberger P, Basset-Seguin N, Bastholt L, Bataille V, Del Marmol V, Dréno B, Fargnoli MC, Forsea AM, Grob JJ, Höller C, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Lytvynenko B, Malvehy J, Moreno-Ramirez D, Nathan P, Pellacani G, Saiag P, Stratigos AJ, Van Akkooi ACJ, Vieira R, Zalaudek I, Lorigan P; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2022 Jul;170:236-255. Epub 2022 May 12 doi: 10.1016/j.ejca.2022.03.008. PMID: 35570085
Current state of melanoma diagnosis and treatment.
Davis LE, Shalin SC, Tackett AJ
Cancer Biol Ther 2019;20(11):1366-1379. Epub 2019 Aug 1 doi: 10.1080/15384047.2019.1640032. PMID: 31366280Free PMC Article
Diagnosis and treatment of basal cell carcinoma: European consensus-based interdisciplinary guidelines.
Peris K, Fargnoli MC, Garbe C, Kaufmann R, Bastholt L, Seguin NB, Bataille V, Marmol VD, Dummer R, Harwood CA, Hauschild A, Höller C, Haedersdal M, Malvehy J, Middleton MR, Morton CA, Nagore E, Stratigos AJ, Szeimies RM, Tagliaferri L, Trakatelli M, Zalaudek I, Eggermont A, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2019 Sep;118:10-34. Epub 2019 Jul 6 doi: 10.1016/j.ejca.2019.06.003. PMID: 31288208

Recent clinical studies

Etiology

Skin cancer: Primary, secondary, and tertiary prevention. Part I.
Perez M, Abisaad JA, Rojas KD, Marchetti MA, Jaimes N
J Am Acad Dermatol 2022 Aug;87(2):255-268. Epub 2022 Feb 14 doi: 10.1016/j.jaad.2021.12.066. PMID: 35176397
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Diagnosis

Skin cancer: Primary, secondary, and tertiary prevention. Part II.
Rojas KD, Perez ME, Marchetti MA, Nichols AJ, Penedo FJ, Jaimes N
J Am Acad Dermatol 2022 Aug;87(2):271-288. Epub 2022 Feb 14 doi: 10.1016/j.jaad.2022.01.053. PMID: 35176398
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Cutaneous Metastasis.
Strickley JD, Jenson AB, Jung JY
Hematol Oncol Clin North Am 2019 Feb;33(1):173-197. doi: 10.1016/j.hoc.2018.08.008. PMID: 30497674
Malignant Melanoma: Beyond the Basics.
Pavri SN, Clune J, Ariyan S, Narayan D
Plast Reconstr Surg 2016 Aug;138(2):330e-340e. doi: 10.1097/PRS.0000000000002367. PMID: 27465194
Paediatric melanoma.
Wood BA
Pathology 2016 Feb;48(2):155-65. Epub 2016 Jan 16 doi: 10.1016/j.pathol.2015.12.001. PMID: 27020388

Therapy

Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.
Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Pre-clinical modeling of cutaneous melanoma.
Rebecca VW, Somasundaram R, Herlyn M
Nat Commun 2020 Jun 5;11(1):2858. doi: 10.1038/s41467-020-15546-9. PMID: 32504051Free PMC Article
European interdisciplinary guideline on invasive squamous cell carcinoma of the skin: Part 2. Treatment.
Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, Bataille V, Bastholt L, Dreno B, Concetta Fargnoli M, Forsea AM, Frenard C, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NWJ, Malvehy J, Del Marmol V, Middleton MR, Moreno-Ramirez D, Pellecani G, Peris K, Saiag P, van den Beuken-van Everdingen MHJ, Vieira R, Zalaudek I, Eggermont AMM, Grob JJ; European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO) and the European Organization for Research and Treatment of Cancer (EORTC)
Eur J Cancer 2020 Mar;128:83-102. Epub 2020 Feb 26 doi: 10.1016/j.ejca.2020.01.008. PMID: 32113942
Diagnosis and Management of Basal Cell Carcinoma.
Tanese K
Curr Treat Options Oncol 2019 Feb 11;20(2):13. doi: 10.1007/s11864-019-0610-0. PMID: 30741348
Cutaneous Metastasis.
Strickley JD, Jenson AB, Jung JY
Hematol Oncol Clin North Am 2019 Feb;33(1):173-197. doi: 10.1016/j.hoc.2018.08.008. PMID: 30497674

Prognosis

The risk of metastases from squamous cell carcinoma of the skin.
Caudill J, Thomas JE, Burkhart CG
Int J Dermatol 2023 Apr;62(4):483-486. Epub 2022 Mar 24 doi: 10.1111/ijd.16164. PMID: 35324009
Cutaneous metastases: A great imitator.
Jaros J, Hunt S, Mose E, Lai O, Tsoukas M
Clin Dermatol 2020 Mar-Apr;38(2):216-222. Epub 2019 Oct 25 doi: 10.1016/j.clindermatol.2019.10.004. PMID: 32513401
Malignant melanoma in HIV: Epidemiology, pathogenesis, and management.
Facciolà A, Venanzi Rullo E, Ceccarelli M, D'Andrea F, Coco M, Micali C, Cacopardo B, Marino A, Cannavò SP, Di Rosa M, Condorelli F, Pellicanò GF, Guarneri C, Nunnari G
Dermatol Ther 2020 Jan;33(1):e13180. Epub 2019 Dec 9 doi: 10.1111/dth.13180. PMID: 31770477
Cutaneous Metastasis.
Strickley JD, Jenson AB, Jung JY
Hematol Oncol Clin North Am 2019 Feb;33(1):173-197. doi: 10.1016/j.hoc.2018.08.008. PMID: 30497674
Genetics of metastasis: melanoma and other cancers.
Turner N, Ware O, Bosenberg M
Clin Exp Metastasis 2018 Aug;35(5-6):379-391. Epub 2018 May 2 doi: 10.1007/s10585-018-9893-y. PMID: 29722002

Clinical prediction guides

Melanoma of the gallbladder.
Bojar P, Burdan F, Wronecki L, Szumiło J
Folia Med Cracov 2023 Jul 30;63(2):77-92. doi: 10.24425/fmc.2023.145915. PMID: 37903381
Single-cell Characterization of the Cellular Landscape of Acral Melanoma Identifies Novel Targets for Immunotherapy.
Li J, Smalley I, Chen Z, Wu JY, Phadke MS, Teer JK, Nguyen T, Karreth FA, Koomen JM, Sarnaik AA, Zager JS, Khushalani NI, Tarhini AA, Sondak VK, Rodriguez PC, Messina JL, Chen YA, Smalley KSM
Clin Cancer Res 2022 May 13;28(10):2131-2146. doi: 10.1158/1078-0432.CCR-21-3145. PMID: 35247927Free PMC Article
Liquid biopsy to monitor melanoma patients.
Gaiser MR, von Bubnoff N, Gebhardt C, Utikal JS
J Dtsch Dermatol Ges 2018 Apr;16(4):405-414. Epub 2018 Mar 7 doi: 10.1111/ddg.13461. PMID: 29512873
GATA3: a multispecific but potentially useful marker in surgical pathology: a systematic analysis of 2500 epithelial and nonepithelial tumors.
Miettinen M, McCue PA, Sarlomo-Rikala M, Rys J, Czapiewski P, Wazny K, Langfort R, Waloszczyk P, Biernat W, Lasota J, Wang Z
Am J Surg Pathol 2014 Jan;38(1):13-22. doi: 10.1097/PAS.0b013e3182a0218f. PMID: 24145643Free PMC Article
Management of immune-related adverse events and kinetics of response with ipilimumab.
Weber JS, Kähler KC, Hauschild A
J Clin Oncol 2012 Jul 20;30(21):2691-7. Epub 2012 May 21 doi: 10.1200/JCO.2012.41.6750. PMID: 22614989

Recent systematic reviews

Systemic Therapy for Melanoma: ASCO Guideline Update.
Seth R, Agarwala SS, Messersmith H, Alluri KC, Ascierto PA, Atkins MB, Bollin K, Chacon M, Davis N, Faries MB, Funchain P, Gold JS, Guild S, Gyorki DE, Kaur V, Khushalani NI, Kirkwood JM, McQuade JL, Meyers MO, Provenzano A, Robert C, Santinami M, Sehdev A, Sondak VK, Spurrier G, Swami U, Truong TG, Tsai KK, van Akkooi A, Weber J
J Clin Oncol 2023 Oct 20;41(30):4794-4820. Epub 2023 Aug 14 doi: 10.1200/JCO.23.01136. PMID: 37579248
Artificial intelligence and machine learning algorithms for early detection of skin cancer in community and primary care settings: a systematic review.
Jones OT, Matin RN, van der Schaar M, Prathivadi Bhayankaram K, Ranmuthu CKI, Islam MS, Behiyat D, Boscott R, Calanzani N, Emery J, Williams HC, Walter FM
Lancet Digit Health 2022 Jun;4(6):e466-e476. doi: 10.1016/S2589-7500(22)00023-1. PMID: 35623799
Current State of Skin Cancer Prevention: A Systematic Review.
Alonso-Belmonte C, Montero-Vilchez T, Arias-Santiago S, Buendía-Eisman A
Actas Dermosifiliogr 2022 Sep;113(8):781-791. Epub 2022 May 5 doi: 10.1016/j.ad.2022.04.015. PMID: 35526566
Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.
Kibbi N, Owen JL, Worley B, Wang JX, Harikumar V, Downing MB, Aasi SZ, Aung PP, Barker CA, Bolotin D, Bordeaux JS, Cartee TV, Chandra S, Cho NL, Choi JN, Chung KY, Cliby WA, Dorigo O, Eisen DB, Fujisawa Y, Golda N, Halfdanarson TR, Iavazzo C, Jiang SIB, Kanitakis J, Khan A, Kim JYS, Kuzel TM, Lawrence N, Leitao MM Jr, MacLean AB, Maher IA, Mittal BB, Nehal KS, Ozog DM, Pettaway CA, Ross JS, Rossi AM, Servaes S, Solomon MJ, Thomas VD, Tolia M, Voelzke BB, Waldman A, Wong MK, Zhou Y, Arai N, Brackett A, Ibrahim SA, Kang BY, Poon E, Alam M
JAMA Oncol 2022 Apr 1;8(4):618-628. doi: 10.1001/jamaoncol.2021.7148. PMID: 35050310
Manual lymphatic drainage for lymphedema following breast cancer treatment.
Ezzo J, Manheimer E, McNeely ML, Howell DM, Weiss R, Johansson KI, Bao T, Bily L, Tuppo CM, Williams AF, Karadibak D
Cochrane Database Syst Rev 2015 May 21;2015(5):CD003475. doi: 10.1002/14651858.CD003475.pub2. PMID: 25994425Free PMC Article

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