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Benign Orbit Neoplasm

MedGen UID:
102304
Concept ID:
C0154023
Neoplastic Process
Synonyms: Benign neoplasm of orbit; Benign Neoplasm of Orbit; Benign Neoplasm of the Orbit; Benign Orbit Tumor; Benign Orbital Neoplasm; Benign orbital tumor; Benign Orbital Tumor; Benign tumor of orbit; Benign Tumor of Orbit; Benign Tumor of the Orbit
SNOMED CT: Benign tumor of orbit (92258000); Benign orbital tumor (92258000); Benign neoplasm of orbit (92258000)

Definition

A neoplasm that arises from the orbit and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Professional guidelines

PubMed

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Tadepalli SH, Shields CL, Shields JA, Honavar SG
Indian J Ophthalmol 2019 Jun;67(6):755-762. doi: 10.4103/ijo.IJO_845_19. PMID: 31124483Free PMC Article
Khong JJ, Moore S, Prabhakaran VC, Selva D
Orbit 2009;28(2-3):88-97. doi: 10.1080/08820530802506094. PMID: 19839890

Recent clinical studies

Etiology

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Cunnane MB, Curtin HD
Handb Clin Neurol 2016;135:659-672. doi: 10.1016/B978-0-444-53485-9.00031-3. PMID: 27432687
Bozza F, Marcelli VA, Pistilli R, Govoni FA, Marsico C
Minerva Stomatol 2006 Apr;55(4):215-22. PMID: 16618996

Diagnosis

Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513

Therapy

Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455
Shome D, Esmaeli B
Curr Opin Ophthalmol 2008 Sep;19(5):414-21. doi: 10.1097/ICU.0b013e32830b1539. PMID: 18772675
Boulos PR, Knoepp SM, Rubin PA
Arch Ophthalmol 2007 Mar;125(3):380-6. doi: 10.1001/archopht.125.3.380. PMID: 17353410

Prognosis

Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

Clinical prediction guides

Furdová A, Babál P
Cesk Slov Oftalmol 2020 Spring;76(2):62-67. doi: 10.31348/2020/13. PMID: 33126800
Snyderman CH, Lavigne P
Adv Otorhinolaryngol 2020;84:106-113. Epub 2020 Jul 30 doi: 10.1159/000457930. PMID: 32731223
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Allen RC
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):60-64. doi: 10.4103/meajo.MEAJO_93_18. PMID: 30122850Free PMC Article

Recent systematic reviews

Javadirad E, Azimivaghar J, Montazer S, Sharafi S
Head Neck Pathol 2022 Dec;16(4):1172-1184. Epub 2022 May 4 doi: 10.1007/s12105-022-01452-7. PMID: 35507301Free PMC Article
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Badran KW, Suh JD, Namiri N, Wrobel B, Ference EH
Am J Rhinol Allergy 2018 Nov;32(6):465-472. Epub 2018 Aug 22 doi: 10.1177/1945892418793475. PMID: 30132339
Tata A, Cohen-Inbar O, Sheehan JP
BMJ Case Rep 2016 Oct 7;2016 doi: 10.1136/bcr-2016-217114. PMID: 27758816Free PMC Article
Lenzi R, Bleier BS, Felisati G, Muscatello L
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2319-22. Epub 2015 Jul 26 doi: 10.1007/s00405-015-3733-3. PMID: 26210157

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