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Benign Orbit Neoplasm

MedGen UID:
102304
•Concept ID:
C0154023
•
Neoplastic Process
Synonyms: Benign neoplasm of orbit; Benign Neoplasm of Orbit; Benign Neoplasm of the Orbit; Benign Orbit Tumor; Benign Orbital Neoplasm; Benign orbital tumor; Benign Orbital Tumor; Benign tumor of orbit; Benign Tumor of Orbit; Benign Tumor of the Orbit
SNOMED CT: Benign tumor of orbit (92258000); Benign orbital tumor (92258000); Benign neoplasm of orbit (92258000)

Definition

A non-metastasizing neoplasm that arises from the orbit. [from NCI]

Professional guidelines

PubMed

Orbital diseases mimicking graves' orbitopathy: a long-standing challenge in differential diagnosis.
Marinò M, Ionni I, Lanzolla G, Sframeli A, Latrofa F, Rocchi R, Marcocci C
J Endocrinol Invest 2020 Apr;43(4):401-411. Epub 2019 Nov 5 doi: 10.1007/s40618-019-01141-3. PMID: 31691261
Intraocular medulloepithelioma - A review of clinical features, DICER 1 mutation, and management.
Tadepalli SH, Shields CL, Shields JA, Honavar SG
Indian J Ophthalmol 2019 Jun;67(6):755-762. doi: 10.4103/ijo.IJO_845_19. PMID: 31124483Free PMC Article
Genetic testing in orbital tumors.
Khong JJ, Moore S, Prabhakaran VC, Selva D
Orbit 2009;28(2-3):88-97. doi: 10.1080/08820530802506094. PMID: 19839890

Recent clinical studies

Etiology

Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
Imaging of orbital disorders.
Cunnane MB, Curtin HD
Handb Clin Neurol 2016;135:659-672. doi: 10.1016/B978-0-444-53485-9.00031-3. PMID: 27432687
Endoscopic sinus surgery for benign and malignant nasal and sinus neoplasm.
Banhiran W, Casiano RR
Curr Opin Otolaryngol Head Neck Surg 2005 Feb;13(1):50-4. doi: 10.1097/00020840-200502000-00012. PMID: 15654216

Diagnosis

Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Orbital dermoid cyst.
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Idiopathic orbital pseudotumour.
Ding ZX, Lip G, Chong V
Clin Radiol 2011 Sep;66(9):886-92. Epub 2011 May 4 doi: 10.1016/j.crad.2011.03.018. PMID: 21546008

Therapy

PET/CT and PET/MRI in ophthalmic oncology (Review).
Kalemaki MS, Karantanas AH, Exarchos D, Detorakis ET, Zoras O, Marias K, Millo C, Bagci U, Pallikaris I, Stratis A, Karatzanis I, Perisinakis K, Koutentakis P, Kontadakis GA, Spandidos DA, Tsatsakis A, Papadakis GZ
Int J Oncol 2020 Feb;56(2):417-429. Epub 2020 Jan 3 doi: 10.3892/ijo.2020.4955. PMID: 31939615Free PMC Article
Sebaceous Carcinoma: A Review of the Scientific Literature.
Knackstedt T, Samie FH
Curr Treat Options Oncol 2017 Aug;18(8):47. doi: 10.1007/s11864-017-0490-0. PMID: 28681210
Orbital pseudotumor.
Mendenhall WM, Lessner AM
Am J Clin Oncol 2010 Jun;33(3):304-6. doi: 10.1097/COC.0b013e3181a07567. PMID: 19738455
Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa.
Shome D, Esmaeli B
Curr Opin Ophthalmol 2008 Sep;19(5):414-21. doi: 10.1097/ICU.0b013e32830b1539. PMID: 18772675
Green bone.
Boulos PR, Knoepp SM, Rubin PA
Arch Ophthalmol 2007 Mar;125(3):380-6. doi: 10.1001/archopht.125.3.380. PMID: 17353410

Prognosis

Intramuscular Eyelid Myxoma.
Liu CK, Williamson JE 3rd, Milman T, Lally SE, Shields CL
Ophthalmic Plast Reconstr Surg 2022 Nov-Dec 01;38(6):e180-e183. Epub 2022 Jul 4 doi: 10.1097/IOP.0000000000002236. PMID: 35793663
Rare Diseases of the Orbit.
Kisser U, Heichel J, Glien A
Laryngorhinootologie 2021 Apr;100(S 01):S1-S79. Epub 2021 Apr 30 doi: 10.1055/a-1384-4641. PMID: 34352903Free PMC Article
Optic nerve sheath meningioma.
Douglas VP, Douglas KAA, Cestari DM
Curr Opin Ophthalmol 2020 Nov;31(6):455-461. doi: 10.1097/ICU.0000000000000700. PMID: 33009076
Overview of benign and malignant lacrimal gland tumors.
Gündüz AK, Yeşiltaş YS, Shields CL
Curr Opin Ophthalmol 2018 Sep;29(5):458-468. doi: 10.1097/ICU.0000000000000515. PMID: 30028745
An Update on Tumors of the Lacrimal Gland.
Andreasen S, Esmaeli B, Holstein SL, Mikkelsen LH, Rasmussen PK, Heegaard S
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172. doi: 10.22608/APO.201707. PMID: 28399336

Clinical prediction guides

Primary Intrabulbar Neurofibroma.
Furdová A, Babál P
Cesk Slov Oftalmol 2020 Spring;76(2):62-67. doi: 10.31348/2020/13. PMID: 33126800
Benign Tumors of the Anterior Cranial Base.
Snyderman CH, Lavigne P
Adv Otorhinolaryngol 2020;84:106-113. Epub 2020 Jul 30 doi: 10.1159/000457930. PMID: 32731223
Dacryops - A review.
Tanaboonyawat S, Idowu OO, Copperman TS, Vagefi MR, Kersten RC
Orbit 2020 Apr;39(2):128-134. Epub 2019 Sep 12 doi: 10.1080/01676830.2019.1608564. PMID: 31512543
Orbital Paraganglioma.
Zhu B, Yan J
J Craniofac Surg 2019 Sep;30(6):e503-e506. doi: 10.1097/SCS.0000000000005408. PMID: 30896513
Orbital Metastases: When to Suspect? When to biopsy?
Allen RC
Middle East Afr J Ophthalmol 2018 Apr-Jun;25(2):60-64. doi: 10.4103/meajo.MEAJO_93_18. PMID: 30122850Free PMC Article

Recent systematic reviews

A Systematic Review of Nasal Chondromesenchymal Hamartoma (NCMH) with a New Case Report.
Javadirad E, Azimivaghar J, Montazer S, Sharafi S
Head Neck Pathol 2022 Dec;16(4):1172-1184. Epub 2022 May 4 doi: 10.1007/s12105-022-01452-7. PMID: 35507301Free PMC Article
Exclusively endoscopic endonasal resection of benign orbital tumors: a systematic review and meta-analysis.
Jafari A, von Sneidern M, Lehmann AE, Shen SA, Shishido S, Freitag SK, Bleier BS
Int Forum Allergy Rhinol 2021 May;11(5):924-934. Epub 2020 Dec 22 doi: 10.1002/alr.22745. PMID: 33350602
Pediatric Benign Paranasal Sinus Osteoneogenic Tumors: A Case Series and Systematic Review of Outcomes, Techniques, and a Multiportal Approach.
Badran KW, Suh JD, Namiri N, Wrobel B, Ference EH
Am J Rhinol Allergy 2018 Nov;32(6):465-472. Epub 2018 Aug 22 doi: 10.1177/1945892418793475. PMID: 30132339
Treatment of orbital solitary fibrous tumour with gamma knife radiosurgery and systematic review of literature.
Tata A, Cohen-Inbar O, Sheehan JP
BMJ Case Rep 2016 Oct 7;2016 doi: 10.1136/bcr-2016-217114. PMID: 27758816Free PMC Article
Purely endoscopic trans-nasal management of orbital intraconal cavernous haemangiomas: a systematic review of the literature.
Lenzi R, Bleier BS, Felisati G, Muscatello L
Eur Arch Otorhinolaryngol 2016 Sep;273(9):2319-22. Epub 2015 Jul 26 doi: 10.1007/s00405-015-3733-3. PMID: 26210157

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