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Pigmented spindle cell nevus

MedGen UID:
105378
Concept ID:
C0474967
Neoplastic Process
Synonyms: Pigmented Spindle Cell Nevus; pigmented spindle cell nevus; Pigmented Spindle Cell Nevus of Reed; Pigmented Spindle Cell Variant of Spitz Nevus; Reed Nevus; Spindle cell nevus of Reed; Spindle Cell Nevus of Reed; spindle cell Nevus of Reed
SNOMED CT: Spindle cell nevus of Reed (254812004)
 
Monarch Initiative: MONDO:0006905

Definition

A benign, small and slightly elevated brown or black skin lesion with usually well-demarcated borders. It is characterized by the presence of a melanocytic proliferation resulting in the formation of uniform cellular nests. Sometimes the clinical and morphologic features may be difficult to distinguish from melanoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPigmented spindle cell nevus

Professional guidelines

PubMed

Aung PP, Mutyambizi KK, Danialan R, Ivan D, Prieto VG
J Clin Pathol 2015 Dec;68(12):963-70. doi: 10.1136/jclinpath-2015-202887. PMID: 26602414
Requena C, Botella R, Nagore E, Sanmartín O, Llombart B, Serra-Guillén C, Guillén C, Requena L, Traves V
Am J Dermatopathol 2012 Jul;34(5):478-86. doi: 10.1097/DAD.0b013e318234e780. PMID: 22257900
Metcalf JS
Semin Oncol 1996 Dec;23(6):688-92. PMID: 8970588

Recent clinical studies

Etiology

Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Barnhill RL, Barnhill MA, Berwick M, Mihm MC Jr
Hum Pathol 1991 Jan;22(1):52-8. doi: 10.1016/0046-8177(91)90061-s. PMID: 1985078

Diagnosis

Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Puri PK, Elston CA, Tyler WB, Ferringer TC, Elston DM
J Cutan Pathol 2011 Jan;38(1):14-7. Epub 2010 Oct 5 doi: 10.1111/j.1600-0560.2010.01624.x. PMID: 21039744
Requena C, Requena L, Sánchez-Yus E, Kutzner H, Llombart B, Sanmartín O, Botella-Estrada R, Nagore E, Serra C, Guillén C
J Cutan Pathol 2008 Oct;35 Suppl 1:87-9. Epub 2008 Jun 28 doi: 10.1111/j.1600-0560.2007.00957.x. PMID: 18547345
Maurichi A, Baldi M, Bartoli C, Bono A, Camerini T, Moglia D, Patuzzo R, Pennacchioli E, Tragni G, Santinami M
Dermatol Online J 2004 Oct 15;10(2):5. PMID: 15530295
Sau P, Graham JH, Helwig EB
J Am Acad Dermatol 1993 Apr;28(4):565-71. doi: 10.1016/0190-9622(93)70075-5. PMID: 8463457

Prognosis

Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Díaz A, Valera A, Carrera C, Hakim S, Aguilera P, García A, Palou J, Puig S, Malvehy J, Alos L
Am J Surg Pathol 2011 Nov;35(11):1733-42. doi: 10.1097/PAS.0b013e318229cf66. PMID: 21997694
Barnhill RL, Barnhill MA, Berwick M, Mihm MC Jr
Hum Pathol 1991 Jan;22(1):52-8. doi: 10.1016/0046-8177(91)90061-s. PMID: 1985078

Clinical prediction guides

Díaz A, Valera A, Carrera C, Hakim S, Aguilera P, García A, Palou J, Puig S, Malvehy J, Alos L
Am J Surg Pathol 2011 Nov;35(11):1733-42. doi: 10.1097/PAS.0b013e318229cf66. PMID: 21997694
Sau P, Graham JH, Helwig EB
J Am Acad Dermatol 1993 Apr;28(4):565-71. doi: 10.1016/0190-9622(93)70075-5. PMID: 8463457

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