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Pigmented Nevus

MedGen UID:
777118
•Concept ID:
C3665593
•
Neoplastic Process
Synonyms: Melanocytic nevi; Pigmented moles; Pigmented nevi; Pigmented nevus
SNOMED CT: Melanocytic nevus of skin (400010006); Pigmented nevus of skin (400010006); Mole of skin (400010006)

Definition

A nevus characterised by the presence of excessive pigment. [from NCI]

Professional guidelines

PubMed

The effect of carbon dioxide lattice laser cosmetic technique in the treatment of pigmented nevus and the evaluation of the improvement of patients' appearance.
Ye S, Zhou D
Minerva Surg 2022 Apr;77(2):195-197. Epub 2021 Aug 3 doi: 10.23736/S2724-5691.21.09041-9. PMID: 34342408
Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis.
Shin H, Kim YG, Kim YE, Park H
J Dermatol 2019 Oct;46(10):843-848. Epub 2019 Aug 6 doi: 10.1111/1346-8138.15035. PMID: 31389056
Diagnosis and treatment of pigmented moles and melanomas.
BECKER SW
Ill Med J 1954 Mar;105(3):113-8. PMID: 13128802

Recent clinical studies

Etiology

Nevi - when to refer.
Shah SA, Jahnke MN
Curr Opin Pediatr 2024 Aug 1;36(4):411-417. Epub 2024 Jun 4 doi: 10.1097/MOP.0000000000001375. PMID: 38957127
Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Childhood melanoma.
Jen M, Murphy M, Grant-Kels JM
Clin Dermatol 2009 Nov-Dec;27(6):529-36. doi: 10.1016/j.clindermatol.2008.09.011. PMID: 19880040
Torpedo maculopathy.
Teitelbaum BA, Hachey DL, Messner LV
J Am Optom Assoc 1997 Jun;68(6):373-6. PMID: 9190137

Diagnosis

Melanocytic naevi, melanocytomas and emerging concepts.
Yeh I
Pathology 2023 Mar;55(2):178-186. Epub 2022 Dec 27 doi: 10.1016/j.pathol.2022.12.341. PMID: 36642570
Phakomatosis Pigmentovascularis.
Tran C, Alward WLM
Ophthalmol Glaucoma 2021 May-Jun;4(3):250. doi: 10.1016/j.ogla.2021.03.003. PMID: 34030827
Kissing naevus.
Lysebo DE, Krohn J
Tidsskr Nor Laegeforen 2021 Jan 12;141(1) Epub 2021 Jan 7 doi: 10.4045/tidsskr.20.0605. PMID: 33433097
Childhood melanoma.
Jen M, Murphy M, Grant-Kels JM
Clin Dermatol 2009 Nov-Dec;27(6):529-36. doi: 10.1016/j.clindermatol.2008.09.011. PMID: 19880040
Nevus spilus.
Vaidya DC, Schwartz RA, Janniger CK
Cutis 2007 Dec;80(6):465-8. PMID: 18246877

Therapy

Pigmented Lesions.
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Eruptive Melanocytic Nevi: A Review.
Burian EA, Jemec GBE
Am J Clin Dermatol 2019 Oct;20(5):669-682. doi: 10.1007/s40257-019-00444-8. PMID: 31119650
Drug-induced eruptive melanocytic nevi.
Vena GA, Fargnoli MC, Cassano N, Argenziano G
Expert Opin Drug Metab Toxicol 2017 Mar;13(3):293-300. Epub 2016 Oct 21 doi: 10.1080/17425255.2017.1247155. PMID: 27759434
Angioadnexocentric nevus.
Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690
Azelaic acid.
Breathnach AS, Nazzaro-Porro M, Passi S
Br J Dermatol 1984 Jul;111(1):115-20. doi: 10.1111/j.1365-2133.1984.tb04025.x. PMID: 6234914

Prognosis

Incidence of neurocutaneous melanosis in Japanese pediatric patients with congenital melanocytic nevi.
Takiya M, Fushimi Y, Sakamoto M, Yoshida T, Ueno K, Nakajima S, Sakata A, Okuchi S, Otani S, Tagawa H, Morimoto N, Nakamoto Y
Sci Rep 2023 Sep 30;13(1):16442. doi: 10.1038/s41598-023-43829-w. PMID: 37777590Free PMC Article
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Melanocytic nevi.
Hauschild A, Egberts F, Garbe C, Bauer J, Grabbe S, Hamm H, Kerl H, Reusch M, Rompel R, Schlaeger M; expert group "Melanocytic nevi"
J Dtsch Dermatol Ges 2011 Sep;9(9):723-34. Epub 2011 Jul 15 doi: 10.1111/j.1610-0387.2011.07741.x. PMID: 21762380
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

Pigmented lesions of the conjunctiva: The sheep and the wolf.
Christy MC, Honavar SG, Mulay K, Talloju SS
Indian J Ophthalmol 2023 Jul;71(7):2927. doi: 10.4103/IJO.IJO_1367_23. PMID: 37417160Free PMC Article
Genodermatoses associated with melanocytic nevi.
Ramseier JY, Perkins SH
Clin Dermatol 2022 Jul-Aug;40(4):339-354. Epub 2022 Feb 15 doi: 10.1016/j.clindermatol.2022.02.007. PMID: 35181411
ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Giant congenital melanocytic nevi.
Arneja JS, Gosain AK
Plast Reconstr Surg 2009 Jul;124(1 Suppl):1e-13e. doi: 10.1097/PRS.0b013e3181ab11be. PMID: 19568135
Mucinous nevus.
Yokogawa M, Kamakura T, Ishiguro H, Ikeda M, Kodama H
J Dermatol 2005 Jan;32(1):30-3. doi: 10.1111/j.1346-8138.2005.tb00710.x. PMID: 15841658

Recent systematic reviews

Changes in melanocytic nevi treated with laser hair removal: A systematic review.
Cices A, Dover JS, Labadie JG
Lasers Surg Med 2023 Sep;55(7):617-624. Epub 2023 Jul 26 doi: 10.1002/lsm.23712. PMID: 37493510
Safety and effectiveness of surgical excision of medium, large, and giant congenital melanocytic nevi: A systematic review and meta-analysis.
Gout HA, Fledderus AC, Lokhorst MM, Pasmans SGMA, Breugem CC, Lapid O, van der Horst CMAM
J Plast Reconstr Aesthet Surg 2023 Feb;77:430-455. Epub 2022 Nov 21 doi: 10.1016/j.bjps.2022.10.048. PMID: 36652871
Risk of melanoma in congenital melanocytic nevi of all sizes: A systematic review.
Scard C, Aubert H, Wargny M, Martin L, Barbarot S
J Eur Acad Dermatol Venereol 2023 Jan;37(1):32-39. Epub 2022 Oct 5 doi: 10.1111/jdv.18581. PMID: 36149403
Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis.
Fledderus AC, Widdershoven AL, Lapid O, Breugem CC, Pasmans SGMA, van der Horst CMAM, Engelen MM, Spuls PI
Orphanet J Rare Dis 2022 Mar 2;17(1):95. doi: 10.1186/s13023-022-02234-8. PMID: 35236387Free PMC Article
Divided nevus of the eyelid: review of embryology, pathology and treatment.
Desai SC, Walen S, Holds JB, Branham G
Am J Otolaryngol 2013 May-Jun;34(3):223-9. Epub 2013 Feb 4 doi: 10.1016/j.amjoto.2013.01.004. PMID: 23380310

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