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Pigmented Nevus

MedGen UID:
777118
•Concept ID:
C3665593
•
Neoplastic Process
Synonyms: Melanocytic nevi; Pigmented moles; Pigmented nevi; Pigmented nevus
SNOMED CT: Melanocytic nevus of skin (400010006); Pigmented nevus of skin (400010006); Mole of skin (400010006)

Definition

A nevus characterised by the presence of excessive pigment. [from NCI]

Professional guidelines

PubMed

The effect of carbon dioxide lattice laser cosmetic technique in the treatment of pigmented nevus and the evaluation of the improvement of patients' appearance.
Ye S, Zhou D
Minerva Surg 2022 Apr;77(2):195-197. Epub 2021 Aug 3 doi: 10.23736/S2724-5691.21.09041-9. PMID: 34342408
Clinical characteristics and treatment of 52 cases of phakomatosis pigmentovascularis.
Shin H, Kim YG, Kim YE, Park H
J Dermatol 2019 Oct;46(10):843-848. Epub 2019 Aug 6 doi: 10.1111/1346-8138.15035. PMID: 31389056
Diagnosis and treatment of pigmented moles and melanomas.
BECKER SW
Ill Med J 1954 Mar;105(3):113-8. PMID: 13128802

Recent clinical studies

Etiology

Care of Congenital Melanocytic Nevi in Newborns and Infants: Review and Management Recommendations.
Jahnke MN, O'Haver J, Gupta D, Hawryluk EB, Finelt N, Kruse L, Jen M, Horii KA, Frieden IJ, Price H, Coughlin CC
Pediatrics 2021 Dec 1;148(6) doi: 10.1542/peds.2021-051536. PMID: 34845496
Congenital melanocytic naevi: An up-to-date overview.
Farabi B, Akay BN, Goldust M, Wollina U, Atak MF, Rao B
Australas J Dermatol 2021 May;62(2):e178-e191. Epub 2021 Feb 16 doi: 10.1111/ajd.13535. PMID: 33591589
Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240
Torpedo maculopathy.
Teitelbaum BA, Hachey DL, Messner LV
J Am Optom Assoc 1997 Jun;68(6):373-6. PMID: 9190137

Diagnosis

Phakomatosis Pigmentovascularis.
Tran C, Alward WLM
Ophthalmol Glaucoma 2021 May-Jun;4(3):250. doi: 10.1016/j.ogla.2021.03.003. PMID: 34030827
Kissing naevus.
Lysebo DE, Krohn J
Tidsskr Nor Laegeforen 2021 Jan 12;141(1) Epub 2021 Jan 7 doi: 10.4045/tidsskr.20.0605. PMID: 33433097
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240
Childhood melanoma.
Jen M, Murphy M, Grant-Kels JM
Clin Dermatol 2009 Nov-Dec;27(6):529-36. doi: 10.1016/j.clindermatol.2008.09.011. PMID: 19880040
Nevus spilus.
Vaidya DC, Schwartz RA, Janniger CK
Cutis 2007 Dec;80(6):465-8. PMID: 18246877

Therapy

Pigmented Lesions.
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Editorial.
Goldberg DJ
J Cosmet Laser Ther 2016 Aug;18(4):187. doi: 10.1080/14764172.2016.1200281. PMID: 27337367
Dermal melanocytosis and associated disorders.
Franceschini D, Dinulos JG
Curr Opin Pediatr 2015 Aug;27(4):480-5. doi: 10.1097/MOP.0000000000000247. PMID: 26087431
Angioadnexocentric nevus.
Hashimoto K, Amano M, Setoyama M
J Dermatol 2012 Nov;39(11):909-15. Epub 2012 Jul 4 doi: 10.1111/j.1346-8138.2012.01599.x. PMID: 22762690
Dermoscopy.
Tanaka M
J Dermatol 2006 Aug;33(8):513-7. doi: 10.1111/j.1346-8138.2006.00126.x. PMID: 16923131

Prognosis

Histologic mimics of malignant melanoma.
Bsirini C, Smoller BR
Singapore Med J 2018 Nov;59(11):602-607. Epub 2018 May 18 doi: 10.11622/smedj.2018041. PMID: 29774360Free PMC Article
Dermal melanocytosis and associated disorders.
Franceschini D, Dinulos JG
Curr Opin Pediatr 2015 Aug;27(4):480-5. doi: 10.1097/MOP.0000000000000247. PMID: 26087431
Management of pigmented conjunctival lesions.
Oellers P, Karp CL
Ocul Surf 2012 Oct;10(4):251-63. Epub 2012 Aug 11 doi: 10.1016/j.jtos.2012.08.002. PMID: 23084146
Congenital melanocytic nevi.
Zayour M, Lazova R
Clin Lab Med 2011 Jun;31(2):267-80. doi: 10.1016/j.cll.2011.03.004. PMID: 21549240
Ancient melanocytic nevus.
Kerl H, Soyer HP, Cerroni L, Wolf IH, Ackerman AB
Semin Diagn Pathol 1998 Aug;15(3):210-5. PMID: 9711671

Clinical prediction guides

ESP, EORTC, and EURACAN Expert Opinion: practical recommendations for the pathological diagnosis and clinical management of intermediate melanocytic tumors and rare related melanoma variants.
de la Fouchardiere A, Blokx W, van Kempen LC, Luzar B, Piperno-Neumann S, Puig S, Alos L, Calonje E, Massi D; ESP Dermatopathology Working Group; EORTC Melanoma Group; EURACAN
Virchows Arch 2021 Jul;479(1):3-11. Epub 2021 Jan 12 doi: 10.1007/s00428-020-03005-1. PMID: 33432480
Lasers.
Passeron T
Ann Dermatol Venereol 2012 Dec;139 Suppl 4:S159-65. doi: 10.1016/S0151-9638(12)70129-1. PMID: 23522632
Giant congenital melanocytic nevi.
Arneja JS, Gosain AK
Plast Reconstr Surg 2007 Aug;120(2):26e-40e. doi: 10.1097/01.prs.0000267583.63342.0a. PMID: 17632335
Mucinous nevus.
Yokogawa M, Kamakura T, Ishiguro H, Ikeda M, Kodama H
J Dermatol 2005 Jan;32(1):30-3. doi: 10.1111/j.1346-8138.2005.tb00710.x. PMID: 15841658
Deep penetrating nevus.
Mehregan DA, Mehregan AH
Arch Dermatol 1993 Mar;129(3):328-31. PMID: 8447669

Recent systematic reviews

Neurological signs, symptoms and MRI abnormalities in patients with congenital melanocytic naevi and evaluation of routine MRI-screening: systematic review and meta-analysis.
Fledderus AC, Widdershoven AL, Lapid O, Breugem CC, Pasmans SGMA, van der Horst CMAM, Engelen MM, Spuls PI
Orphanet J Rare Dis 2022 Mar 2;17(1):95. doi: 10.1186/s13023-022-02234-8. PMID: 35236387Free PMC Article
Neonatal Blue Light Phototherapy and Melanocytic Nevus Count in Children: A Systematic Review and Meta-Analysis of Observational Studies.
Lai YC, Yew YW
Pediatr Dermatol 2016 Jan-Feb;33(1):62-8. Epub 2015 Dec 8 doi: 10.1111/pde.12730. PMID: 26645992
Divided nevus of the eyelid: review of embryology, pathology and treatment.
Desai SC, Walen S, Holds JB, Branham G
Am J Otolaryngol 2013 May-Jun;34(3):223-9. Epub 2013 Feb 4 doi: 10.1016/j.amjoto.2013.01.004. PMID: 23380310
Large congenital melanocytic nevi: therapeutic management and melanoma risk: a systematic review.
Vourc'h-Jourdain M, Martin L, Barbarot S; aRED
J Am Acad Dermatol 2013 Mar;68(3):493-8.e1-14. Epub 2012 Nov 19 doi: 10.1016/j.jaad.2012.09.039. PMID: 23182059
Sunscreen use and melanocytic nevi in children: a systematic review.
de Maleissye MF, Beauchet A, Saiag P, Corrêa M, Godin-Beeckmann S, Haeffelin M, Mahé E
Pediatr Dermatol 2013 Jan-Feb;30(1):51-9. Epub 2012 Sep 20 doi: 10.1111/j.1525-1470.2012.01847.x. PMID: 22994908

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