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Elevated circulating lysophosphatidylcholine concentration

MedGen UID:
1053820
•Concept ID:
CN376999
•
Finding
HPO: HP:6000403

Definition

The concentration of lysophosphatidylcholines in the blood circulation is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated circulating lysophosphatidylcholine concentration

Recent clinical studies

Etiology

Graduate Student Literature Review: A scoping review on the impact of consumption of dairy products on phosphatidylcholine and lysophosphatidylcholine in circulation and the liver in human studies and animal models.
Yuzbashian E, Moftah S, Chan CB
J Dairy Sci 2023 Jan;106(1):24-38. Epub 2022 Nov 16 doi: 10.3168/jds.2022-21938. PMID: 36400621
Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A.
Rached F, Lhomme M, Camont L, Gomes F, Dauteuille C, Robillard P, Santos RD, Lesnik P, Serrano CV Jr, Chapman MJ, Kontush A
Biochim Biophys Acta 2015 Sep;1851(9):1254-61. Epub 2015 May 30 doi: 10.1016/j.bbalip.2015.05.007. PMID: 26037829

Diagnosis

Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A.
Rached F, Lhomme M, Camont L, Gomes F, Dauteuille C, Robillard P, Santos RD, Lesnik P, Serrano CV Jr, Chapman MJ, Kontush A
Biochim Biophys Acta 2015 Sep;1851(9):1254-61. Epub 2015 May 30 doi: 10.1016/j.bbalip.2015.05.007. PMID: 26037829
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Murph M, Tanaka T, Pang J, Felix E, Liu S, Trost R, Godwin AK, Newman R, Mills G
Methods Enzymol 2007;433:1-25. doi: 10.1016/S0076-6879(07)33001-2. PMID: 17954226

Prognosis

Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A.
Rached F, Lhomme M, Camont L, Gomes F, Dauteuille C, Robillard P, Santos RD, Lesnik P, Serrano CV Jr, Chapman MJ, Kontush A
Biochim Biophys Acta 2015 Sep;1851(9):1254-61. Epub 2015 May 30 doi: 10.1016/j.bbalip.2015.05.007. PMID: 26037829
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Murph M, Tanaka T, Pang J, Felix E, Liu S, Trost R, Godwin AK, Newman R, Mills G
Methods Enzymol 2007;433:1-25. doi: 10.1016/S0076-6879(07)33001-2. PMID: 17954226

Clinical prediction guides

Defective functionality of small, dense HDL3 subpopulations in ST segment elevation myocardial infarction: Relevance of enrichment in lysophosphatidylcholine, phosphatidic acid and serum amyloid A.
Rached F, Lhomme M, Camont L, Gomes F, Dauteuille C, Robillard P, Santos RD, Lesnik P, Serrano CV Jr, Chapman MJ, Kontush A
Biochim Biophys Acta 2015 Sep;1851(9):1254-61. Epub 2015 May 30 doi: 10.1016/j.bbalip.2015.05.007. PMID: 26037829
Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: potential biomarkers for cancer diagnosis.
Murph M, Tanaka T, Pang J, Felix E, Liu S, Trost R, Godwin AK, Newman R, Mills G
Methods Enzymol 2007;433:1-25. doi: 10.1016/S0076-6879(07)33001-2. PMID: 17954226
LDL oxidative modifications in well- or moderately controlled type 2 diabetes.
Scheffer PG, Henry RM, Wever EJ, van Rooij GJ, Bos G, Heine RJ, Dekker JM, Diamant M, Stehouwer CD, Nijpels G, Blankenstein MA, Teerlink T
Diabetes Metab Res Rev 2004 Jul-Aug;20(4):298-304. doi: 10.1002/dmrr.461. PMID: 15250032

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