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Abnormal circulating free fatty acid concentration

MedGen UID:
1386581
•Concept ID:
C4477038
•
Finding
Synonym: Abnormal circulating free fatty acid level
 
HPO: HP:0040300

Definition

Any deviation from the normal concentration of a free fatty acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating free fatty acid concentration

Professional guidelines

PubMed

Twenty-four hour hormonal and metabolic profiles in uraemic patients before and during treatment with continuous ambulatory peritoneal dialysis.
Heaton A, Johnston DG, Haigh JW, Ward MK, Alberti KG, Kerr DN
Clin Sci (Lond) 1985 Oct;69(4):449-57. doi: 10.1042/cs0690449. PMID: 4042546

Recent clinical studies

Etiology

The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.
Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC
Prostaglandins Leukot Essent Fatty Acids 2021 Jun;169:102236. Epub 2020 Dec 24 doi: 10.1016/j.plefa.2020.102236. PMID: 33906081
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Role of body fat distribution and the metabolic complications of obesity.
Jensen MD
J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S57-63. doi: 10.1210/jc.2008-1585. PMID: 18987271Free PMC Article
Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398
Membrane proteins implicated in long-chain fatty acid uptake by mammalian cells: CD36, FATP and FABPm.
Abumrad N, Coburn C, Ibrahimi A
Biochim Biophys Acta 1999 Oct 18;1441(1):4-13. doi: 10.1016/s1388-1981(99)00137-7. PMID: 10526223

Diagnosis

Circulating Inhibitory Factor 1 levels in adult patients with Prader-Willi syndrome.
Delvecchio M, Grugni G, Mai S, Favoino E, Ingletto A, Gnoni A
Horm Mol Biol Clin Investig 2021 Mar 5;42(3):317-320. doi: 10.1515/hmbci-2020-0097. PMID: 33675216
Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Contribution of triglyceride-rich lipoproteins to plasma free fatty acids.
Miles JM, Nelson RH
Horm Metab Res 2007 Oct;39(10):726-9. doi: 10.1055/s-2007-990273. PMID: 17952834
Vascular function, insulin resistance and fatty acids.
Steinberg HO, Baron AD
Diabetologia 2002 May;45(5):623-34. Epub 2002 Apr 4 doi: 10.1007/s00125-002-0800-2. PMID: 12107742
PET contributions to understanding normal and abnormal cardiac perfusion and metabolism.
Schelbert HR
Ann Biomed Eng 2000 Aug;28(8):922-9. doi: 10.1114/1.1310216. PMID: 11144676

Therapy

The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.
Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC
Prostaglandins Leukot Essent Fatty Acids 2021 Jun;169:102236. Epub 2020 Dec 24 doi: 10.1016/j.plefa.2020.102236. PMID: 33906081
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398
Plasma and lipoprotein fatty acid composition in glycogen storage disease type I.
Levy E, Letarte J, Lepage G, Thibault L, Roy CC
Lipids 1987 Jun;22(6):381-5. doi: 10.1007/BF02537265. PMID: 3475522
Metabolism and function of myo-inositol and inositol phospholipids.
Holub BJ
Annu Rev Nutr 1986;6:563-97. doi: 10.1146/annurev.nu.06.070186.003023. PMID: 2425833

Prognosis

Plasma lipidome profiling of newborns with antenatal exposure to Zika virus.
da Costa Faria NR, Chaves-Filho AB, Alcantara LCJ, de Siqueira IC, Calcagno JI, Miyamoto S, de Filippis AMB, Yoshinaga MY
PLoS Negl Trop Dis 2021 Apr;15(4):e0009388. Epub 2021 Apr 30 doi: 10.1371/journal.pntd.0009388. PMID: 33930014Free PMC Article
Reduced circulating stem cells associate with excess fasting and post-load NEFA exposure in healthy adults with normal glucose tolerance.
Fadini GP, Tura A, Pacini G, Avogaro A, Vigili de Kreutzenberg S
Atherosclerosis 2017 Jun;261:117-123. Epub 2017 Mar 6 doi: 10.1016/j.atherosclerosis.2017.03.002. PMID: 28298252
Role of body fat distribution and the metabolic complications of obesity.
Jensen MD
J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S57-63. doi: 10.1210/jc.2008-1585. PMID: 18987271Free PMC Article
Temporal patterns of circulating leptin levels in lean and obese adolescents: relationships to insulin, growth hormone, and free fatty acids rhythmicity.
Heptulla R, Smitten A, Teague B, Tamborlane WV, Ma YZ, Caprio S
J Clin Endocrinol Metab 2001 Jan;86(1):90-6. doi: 10.1210/jcem.86.1.7136. PMID: 11231983
Blood ketone bodies in congestive heart failure.
Lommi J, Kupari M, Koskinen P, Näveri H, Leinonen H, Pulkki K, Härkönen M
J Am Coll Cardiol 1996 Sep;28(3):665-72. doi: 10.1016/0735-1097(96)00214-8. PMID: 8772754

Clinical prediction guides

Plasma lipidome profiling of newborns with antenatal exposure to Zika virus.
da Costa Faria NR, Chaves-Filho AB, Alcantara LCJ, de Siqueira IC, Calcagno JI, Miyamoto S, de Filippis AMB, Yoshinaga MY
PLoS Negl Trop Dis 2021 Apr;15(4):e0009388. Epub 2021 Apr 30 doi: 10.1371/journal.pntd.0009388. PMID: 33930014Free PMC Article
The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.
Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC
Prostaglandins Leukot Essent Fatty Acids 2021 Jun;169:102236. Epub 2020 Dec 24 doi: 10.1016/j.plefa.2020.102236. PMID: 33906081
Role of body fat distribution and the metabolic complications of obesity.
Jensen MD
J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S57-63. doi: 10.1210/jc.2008-1585. PMID: 18987271Free PMC Article
Adipocyte fatty acid-binding protein is associated with markers of obesity, but is an unlikely link between obesity, insulin resistance, and hyperandrogenism in polycystic ovary syndrome women.
Möhlig M, Weickert MO, Ghadamgadai E, Machlitt A, Pfüller B, Arafat AM, Pfeiffer AF, Schöfl C
Eur J Endocrinol 2007 Aug;157(2):195-200. doi: 10.1530/EJE-07-0102. PMID: 17656598
Splanchnic circulation and metabolism in patients with acute liver failure.
Clemmesen O
Dan Med Bull 2002 Aug;49(3):177-93. PMID: 12238280

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