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Abnormal circulating fatty-acid concentration

MedGen UID:
892372
•Concept ID:
C4021656
•
Finding
Synonym: Abnormality of fatty-acid metabolism
 
HPO: HP:0004359

Definition

A deviation from the normal concentration of a fatty acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating fatty-acid concentration

Professional guidelines

PubMed

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.
Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q
Front Immunol 2021;12:661990. Epub 2021 Apr 19 doi: 10.3389/fimmu.2021.661990. PMID: 33953724Free PMC Article
Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.
Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729

Recent clinical studies

Etiology

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Serum fatty acid profile in psoriasis and its comorbidity.
Myśliwiec H, Baran A, Harasim-Symbor E, Myśliwiec P, Milewska AJ, Chabowski A, Flisiak I
Arch Dermatol Res 2017 Jul;309(5):371-380. Epub 2017 Jun 5 doi: 10.1007/s00403-017-1748-x. PMID: 28585093Free PMC Article
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article

Diagnosis

Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina.
Lu YC, Lee TL, Hsuan CF, Hung WC, Wu CC, Wang CP, Wei CT, Yu TH, Chung FM, Lee YJ, Tsai IT
Int J Med Sci 2021;18(9):2076-2085. Epub 2021 Mar 11 doi: 10.7150/ijms.54508. PMID: 33850478Free PMC Article
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Vascular function, insulin resistance and fatty acids.
Steinberg HO, Baron AD
Diabetologia 2002 May;45(5):623-34. Epub 2002 Apr 4 doi: 10.1007/s00125-002-0800-2. PMID: 12107742
PET contributions to understanding normal and abnormal cardiac perfusion and metabolism.
Schelbert HR
Ann Biomed Eng 2000 Aug;28(8):922-9. doi: 10.1114/1.1310216. PMID: 11144676
Control of glycaemia.
Gerich JE
Baillieres Clin Endocrinol Metab 1993 Jul;7(3):551-86. doi: 10.1016/s0950-351x(05)80207-1. PMID: 8379904

Therapy

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.
Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q
Front Immunol 2021;12:661990. Epub 2021 Apr 19 doi: 10.3389/fimmu.2021.661990. PMID: 33953724Free PMC Article
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Chia (Salvia hispanica)-supplemented diet ameliorates non-alcoholic fatty liver disease and its metabolic abnormalities in humans.
Medina-Urrutia A, Lopez-Uribe AR, El Hafidi M, González-Salazar MDC, Posadas-Sánchez R, Jorge-Galarza E, Del Valle-Mondragón L, Juárez-Rojas JG
Lipids Health Dis 2020 May 19;19(1):96. doi: 10.1186/s12944-020-01283-x. PMID: 32430018Free PMC Article
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Metabolic changes after cardiac surgery.
Jakob SM, Ensinger H, Takala J
Curr Opin Clin Nutr Metab Care 2001 Mar;4(2):149-55. doi: 10.1097/00075197-200103000-00012. PMID: 11224661

Prognosis

Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Elevated plasma fatty acid-binding protein 3 is related to prolonged corrected QT interval and reduced ejection fraction in patients with stable angina.
Lu YC, Lee TL, Hsuan CF, Hung WC, Wu CC, Wang CP, Wei CT, Yu TH, Chung FM, Lee YJ, Tsai IT
Int J Med Sci 2021;18(9):2076-2085. Epub 2021 Mar 11 doi: 10.7150/ijms.54508. PMID: 33850478Free PMC Article
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
Int J Mol Sci 2019 Jul 2;20(13) doi: 10.3390/ijms20133264. PMID: 31269778Free PMC Article
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Nuclear Magnetic Resonance-Based Metabolomics and Risk of CKD.
Geng TT, Chen JX, Lu Q, Wang PL, Xia PF, Zhu K, Li Y, Guo KQ, Yang K, Liao YF, Zhou YF, Liu G, Pan A
Am J Kidney Dis 2024 Jan;83(1):9-17. Epub 2023 Sep 9 doi: 10.1053/j.ajkd.2023.05.014. PMID: 37678743
Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Plasma lipidome profiling of newborns with antenatal exposure to Zika virus.
da Costa Faria NR, Chaves-Filho AB, Alcantara LCJ, de Siqueira IC, Calcagno JI, Miyamoto S, de Filippis AMB, Yoshinaga MY
PLoS Negl Trop Dis 2021 Apr;15(4):e0009388. Epub 2021 Apr 30 doi: 10.1371/journal.pntd.0009388. PMID: 33930014Free PMC Article
Serum fatty acid profile in psoriasis and its comorbidity.
Myśliwiec H, Baran A, Harasim-Symbor E, Myśliwiec P, Milewska AJ, Chabowski A, Flisiak I
Arch Dermatol Res 2017 Jul;309(5):371-380. Epub 2017 Jun 5 doi: 10.1007/s00403-017-1748-x. PMID: 28585093Free PMC Article
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Recent systematic reviews

Influence of Statins on Circulating Inflammatory Cytokines in Patients With Abnormal Glucose Homeostasis: A Meta-analysis of Data From Randomized Controlled Trials.
Milajerdi A, Sadeghi A, Mousavi SM, Larijani B, Esmaillzadeh A
Clin Ther 2020 Feb;42(2):e13-e31. Epub 2020 Jan 17 doi: 10.1016/j.clinthera.2019.12.009. PMID: 31955966

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