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Abnormal circulating fatty-acid concentration

MedGen UID:
892372
•Concept ID:
C4021656
•
Finding
Synonym: Abnormality of fatty-acid metabolism
 
HPO: HP:0004359

Definition

A deviation from the normal concentration of a fatty acid in the blood circulation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal circulating fatty-acid concentration

Professional guidelines

PubMed

The Architecture of Circulating Immune Cells Is Dysregulated in People Living With HIV on Long Term Antiretroviral Treatment and Relates With Markers of the HIV-1 Reservoir, Cytomegalovirus, and Microbial Translocation.
Van de Wijer L, van der Heijden WA, Ter Horst R, Jaeger M, Trypsteen W, Rutsaert S, van Cranenbroek B, van Rijssen E, Joosten I, Joosten L, Vandekerckhove L, Schoofs T, van Lunzen J, Netea MG, Koenen HJPM, van der Ven AJAM, de Mast Q
Front Immunol 2021;12:661990. Epub 2021 Apr 19 doi: 10.3389/fimmu.2021.661990. PMID: 33953724Free PMC Article
Treprostinil treatment decreases circulating platelet microvesicles and their procoagulant activity in pediatric pulmonary hypertension.
Bacha NC, Levy M, Guerin CL, Le Bonniec B, Harroche A, Szezepanski I, Renard JM, Gaussem P, Israel-Biet D, Boulanger CM, Smadja DM
Pediatr Pulmonol 2019 Jan;54(1):66-72. Epub 2018 Nov 28 doi: 10.1002/ppul.24190. PMID: 30485728
Circulating levels of allopregnanolone, a neuroactive steroid, and leptin during treatment with valproic acid in children with epilepsy.
Grosso S, Luisi S, Mostardini R, Matera M, Barlocco EG, Casarosa E, Balestri P, Petraglia F
Neuroendocrinology 2011;93(3):159-64. Epub 2010 Oct 27 doi: 10.1159/000321664. PMID: 20980729

Recent clinical studies

Etiology

Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.
Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC
Prostaglandins Leukot Essent Fatty Acids 2021 Jun;169:102236. Epub 2020 Dec 24 doi: 10.1016/j.plefa.2020.102236. PMID: 33906081
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Serum fatty acid profile in psoriasis and its comorbidity.
Myśliwiec H, Baran A, Harasim-Symbor E, Myśliwiec P, Milewska AJ, Chabowski A, Flisiak I
Arch Dermatol Res 2017 Jul;309(5):371-380. Epub 2017 Jun 5 doi: 10.1007/s00403-017-1748-x. PMID: 28585093Free PMC Article
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article

Diagnosis

Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Guevara-Cruz M, Godinez-Salas ET, Sanchez-Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizar-Heredia R, Arteaga-Sanchez L, Gamba G, Mojica-Espinosa R, Schcolnik-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR
BMJ Open Diabetes Res Care 2020 Mar;8(1) doi: 10.1136/bmjdrc-2019-000948. PMID: 32152146Free PMC Article
Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study.
Colter AL, Cutler C, Meckling KA
Nutr J 2008 Feb 14;7:8. doi: 10.1186/1475-2891-7-8. PMID: 18275609Free PMC Article
PET contributions to understanding normal and abnormal cardiac perfusion and metabolism.
Schelbert HR
Ann Biomed Eng 2000 Aug;28(8):922-9. doi: 10.1114/1.1310216. PMID: 11144676
Control of glycaemia.
Gerich JE
Baillieres Clin Endocrinol Metab 1993 Jul;7(3):551-86. doi: 10.1016/s0950-351x(05)80207-1. PMID: 8379904

Therapy

The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.
Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC
Prostaglandins Leukot Essent Fatty Acids 2021 Jun;169:102236. Epub 2020 Dec 24 doi: 10.1016/j.plefa.2020.102236. PMID: 33906081
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Genistein stimulates insulin sensitivity through gut microbiota reshaping and skeletal muscle AMPK activation in obese subjects.
Guevara-Cruz M, Godinez-Salas ET, Sanchez-Tapia M, Torres-Villalobos G, Pichardo-Ontiveros E, Guizar-Heredia R, Arteaga-Sanchez L, Gamba G, Mojica-Espinosa R, Schcolnik-Cabrera A, Granados O, López-Barradas A, Vargas-Castillo A, Torre-Villalvazo I, Noriega LG, Torres N, Tovar AR
BMJ Open Diabetes Res Care 2020 Mar;8(1) doi: 10.1136/bmjdrc-2019-000948. PMID: 32152146Free PMC Article
Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes.
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS
Am J Clin Nutr 2010 Dec;92(6):1350-8. Epub 2010 Oct 13 doi: 10.3945/ajcn.110.003970. PMID: 20943795Free PMC Article
Rationale for a metabolic approach in diabetic coronary patients.
Stanley WC
Coron Artery Dis 2005 Nov;16 Suppl 1:S11-5. doi: 10.1097/00019501-200511001-00003. PMID: 16340398

Prognosis

Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
Ileal bile acid transporter inhibition as an anticholestatic therapeutic target in biliary atresia and other cholestatic disorders.
Karpen SJ, Kelly D, Mack C, Stein P
Hepatol Int 2020 Sep;14(5):677-689. Epub 2020 Jul 11 doi: 10.1007/s12072-020-10070-w. PMID: 32653991
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy.
Evangelista I, Nuti R, Picchioni T, Dotta F, Palazzuoli A
Int J Mol Sci 2019 Jul 2;20(13) doi: 10.3390/ijms20133264. PMID: 31269778Free PMC Article
Role of body fat distribution and the metabolic complications of obesity.
Jensen MD
J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S57-63. doi: 10.1210/jc.2008-1585. PMID: 18987271Free PMC Article
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Clinical prediction guides

Circulating Bile Acid Profiles: A Need for Further Examination.
Qi L, Tian Y, Chen Y
J Clin Endocrinol Metab 2021 Oct 21;106(11):3093-3112. doi: 10.1210/clinem/dgab531. PMID: 34279029
The effect of a 6-month ketogenic medium-chain triglyceride supplement on plasma cardiometabolic and inflammatory markers in mild cognitive impairment.
Myette-Côté É, St-Pierre V, Beaulieu S, Castellano CA, Fortier M, Plourde M, Bocti C, Fulop T, Cunnane SC
Prostaglandins Leukot Essent Fatty Acids 2021 Jun;169:102236. Epub 2020 Dec 24 doi: 10.1016/j.plefa.2020.102236. PMID: 33906081
Serum fatty acid profile in psoriasis and its comorbidity.
Myśliwiec H, Baran A, Harasim-Symbor E, Myśliwiec P, Milewska AJ, Chabowski A, Flisiak I
Arch Dermatol Res 2017 Jul;309(5):371-380. Epub 2017 Jun 5 doi: 10.1007/s00403-017-1748-x. PMID: 28585093Free PMC Article
Role of body fat distribution and the metabolic complications of obesity.
Jensen MD
J Clin Endocrinol Metab 2008 Nov;93(11 Suppl 1):S57-63. doi: 10.1210/jc.2008-1585. PMID: 18987271Free PMC Article
Alpha-fetoprotein in abortion.
Seppälä M, Ruoslahti E
Br Med J 1972 Dec 30;4(5843):769-71. doi: 10.1136/bmj.4.5843.769. PMID: 4646508Free PMC Article

Recent systematic reviews

Influence of Statins on Circulating Inflammatory Cytokines in Patients With Abnormal Glucose Homeostasis: A Meta-analysis of Data From Randomized Controlled Trials.
Milajerdi A, Sadeghi A, Mousavi SM, Larijani B, Esmaillzadeh A
Clin Ther 2020 Feb;42(2):e13-e31. Epub 2020 Jan 17 doi: 10.1016/j.clinthera.2019.12.009. PMID: 31955966

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