U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Elevated urinary mandelic acid

MedGen UID:
1054702
•Concept ID:
CN378351
•
Finding
HPO: HP:6000999

Definition

The amount of mandelic acid in the urine, normalized for urine concentration, is above the upper limit of normal. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVElevated urinary mandelic acid

Professional guidelines

PubMed

Urinary catecholamines and their metabolites in management of neuroblastoma.
Eldeeb BB, Hammond EM, Worthington DJ, Mann JR
Pediatr Hematol Oncol 1988;5(3):229-37. doi: 10.3109/08880018809031273. PMID: 3152967

Recent clinical studies

Etiology

Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence.
Xia B, Zhu Q, Zhao Y, Ge W, Zhao Y, Song Q, Zhou Y, Shi H, Zhang Y
Environ Int 2018 Dec;121(Pt 1):159-168. Epub 2018 Sep 9 doi: 10.1016/j.envint.2018.09.001. PMID: 30208345
Biomonitoring of styrene occupational exposures: Biomarkers and determinants.
Persoons R, Richard J, Herve C, Montlevier S, Marques M, Maitre A
Toxicol Lett 2018 Dec 1;298:99-105. Epub 2018 Jun 22 doi: 10.1016/j.toxlet.2018.06.1211. PMID: 29940302
Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey.
Xu C, Liu Q, Liu H, Héroux P, Zhang Q, Jiang ZY, Gu A
PLoS One 2015;10(5):e0127451. Epub 2015 May 21 doi: 10.1371/journal.pone.0127451. PMID: 25996772Free PMC Article
Study of urinary concentrations of mandelic acid in employees exposed to styrene.
Poláková M, Krajcovicová Z, Melus V, Stefkovicová M, Sulcová M
Cent Eur J Public Health 2012 Sep;20(3):226-32. doi: 10.21101/cejph.a3649. PMID: 23285526
Genetic effects and biotoxicity monitoring of occupational styrene exposure.
Rueff J, Teixeira JP, Santos LS, Gaspar JF
Clin Chim Acta 2009 Jan;399(1-2):8-23. Epub 2008 Sep 20 doi: 10.1016/j.cca.2008.09.012. PMID: 18845133

Diagnosis

Study of urinary concentrations of mandelic acid in employees exposed to styrene.
Poláková M, Krajcovicová Z, Melus V, Stefkovicová M, Sulcová M
Cent Eur J Public Health 2012 Sep;20(3):226-32. doi: 10.21101/cejph.a3649. PMID: 23285526
Evaluation of long-term occupational exposure to styrene vapor on olfactory function.
Dalton P, Lees PS, Gould M, Dilks D, Stefaniak A, Bader M, Ihrig A, Triebig G
Chem Senses 2007 Oct;32(8):739-47. Epub 2007 Jun 29 doi: 10.1093/chemse/bjm041. PMID: 17602142
Childhood sporadic pheochromocytoma: clinical profile and outcome in 19 patients.
Bhansali A, Rajput R, Behra A, Rao KL, Khandelwal N, Radotra BD
J Pediatr Endocrinol Metab 2006 May;19(5):749-56. doi: 10.1515/jpem.2006.19.5.749. PMID: 16789642
Abdominal and pelvic extra-adrenal paraganglioma: a review of literature and a report on 7 cases.
Ali-el-Dein B, el-Sobky E, el-Baz M, Shaaban AA
In Vivo 2002 Jul-Aug;16(4):249-54. PMID: 12224134
Cyclic Cushing's syndrome due to ectopic ACTH secretion by an adrenal pheochromocytoma.
Terzolo M, Alì A, Pia A, Bollito E, Reimondo G, Paccotti P, Scardapane R, Angeli A
J Endocrinol Invest 1994 Dec;17(11):869-74. doi: 10.1007/BF03347794. PMID: 7745235

Therapy

Biomonitoring of styrene occupational exposures: Biomarkers and determinants.
Persoons R, Richard J, Herve C, Montlevier S, Marques M, Maitre A
Toxicol Lett 2018 Dec 1;298:99-105. Epub 2018 Jun 22 doi: 10.1016/j.toxlet.2018.06.1211. PMID: 29940302
DNA damage and susceptibility assessment in industrial workers exposed to styrene.
Costa C, Costa S, Silva S, Coelho P, Botelho M, Gaspar J, Rueff J, Laffon B, Teixeira JP
J Toxicol Environ Health A 2012;75(13-15):735-46. doi: 10.1080/15287394.2012.688488. PMID: 22788361
Childhood sporadic pheochromocytoma: clinical profile and outcome in 19 patients.
Bhansali A, Rajput R, Behra A, Rao KL, Khandelwal N, Radotra BD
J Pediatr Endocrinol Metab 2006 May;19(5):749-56. doi: 10.1515/jpem.2006.19.5.749. PMID: 16789642
Phaeochromocytoma: an unusual cause of hypertension in pregnancy.
Bullough A, Karadia S, Watters M
Anaesthesia 2001 Jan;56(1):43-6. doi: 10.1046/j.1365-2044.2001.01726.x. PMID: 11167434
Phenylalanine metabolism in uremic and normal man.
Jones MR, Kopple JD, Swendseid ME
Kidney Int 1978 Aug;14(2):169-79. doi: 10.1038/ki.1978.104. PMID: 357810

Prognosis

Study of urinary concentrations of mandelic acid in employees exposed to styrene.
Poláková M, Krajcovicová Z, Melus V, Stefkovicová M, Sulcová M
Cent Eur J Public Health 2012 Sep;20(3):226-32. doi: 10.21101/cejph.a3649. PMID: 23285526
Utility of follow-up studies using meta-[123 I]iodobenzylguanidine scintigraphy for detecting recurrent neuroblastoma.
Okuyama C, Ushijima Y, Kubota T, Nakamura T, Kikkawa M, Nishimura T
Nucl Med Commun 2002 Jul;23(7):663-72. doi: 10.1097/00006231-200207000-00011. PMID: 12089489
Neuroblastoma in southern Africa: epidemiological features, prognostic factors and outcome.
Hesseling PB, Ankone K, Wessels G, Schneider JW, Du Plessis L, Moore S
Ann Trop Paediatr 1999 Dec;19(4):357-63. doi: 10.1080/02724939992202. PMID: 10716030
Urinary catecholamines and their metabolites in management of neuroblastoma.
Eldeeb BB, Hammond EM, Worthington DJ, Mann JR
Pediatr Hematol Oncol 1988;5(3):229-37. doi: 10.3109/08880018809031273. PMID: 3152967
Serum neuron-specific enolase as a marker useful for monitoring the effectiveness of therapy in patients with neuroblastoma--as compared with urinary catecholamine metabolites.
Hashimoto K, Gotoh Y, Tada K
Tohoku J Exp Med 1986 May;149(1):25-30. doi: 10.1620/tjem.149.25. PMID: 3738914

Clinical prediction guides

Phthalate exposure and childhood overweight and obesity: Urinary metabolomic evidence.
Xia B, Zhu Q, Zhao Y, Ge W, Zhao Y, Song Q, Zhou Y, Shi H, Zhang Y
Environ Int 2018 Dec;121(Pt 1):159-168. Epub 2018 Sep 9 doi: 10.1016/j.envint.2018.09.001. PMID: 30208345
Biomonitoring of styrene occupational exposures: Biomarkers and determinants.
Persoons R, Richard J, Herve C, Montlevier S, Marques M, Maitre A
Toxicol Lett 2018 Dec 1;298:99-105. Epub 2018 Jun 22 doi: 10.1016/j.toxlet.2018.06.1211. PMID: 29940302
Low Serum Testosterone Levels Are Associated with Elevated Urinary Mandelic Acid, and Strontium Levels in Adult Men According to the US 2011-2012 National Health and Nutrition Examination Survey.
Xu C, Liu Q, Liu H, Héroux P, Zhang Q, Jiang ZY, Gu A
PLoS One 2015;10(5):e0127451. Epub 2015 May 21 doi: 10.1371/journal.pone.0127451. PMID: 25996772Free PMC Article
DNA damage and susceptibility assessment in industrial workers exposed to styrene.
Costa C, Costa S, Silva S, Coelho P, Botelho M, Gaspar J, Rueff J, Laffon B, Teixeira JP
J Toxicol Environ Health A 2012;75(13-15):735-46. doi: 10.1080/15287394.2012.688488. PMID: 22788361
Evaluation of long-term occupational exposure to styrene vapor on olfactory function.
Dalton P, Lees PS, Gould M, Dilks D, Stefaniak A, Bader M, Ihrig A, Triebig G
Chem Senses 2007 Oct;32(8):739-47. Epub 2007 Jun 29 doi: 10.1093/chemse/bjm041. PMID: 17602142

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...