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Post-kala-azar dermal leishmaniasis

MedGen UID:
10868
Concept ID:
C0032749
Disease or Syndrome
Synonyms: PKDL - Post-Kala-azar dermal leishmanioid; Post Kala-Azar Dermal Leishmaniasis; Post-Kala-azar dermal leishmanioid
SNOMED CT: Post-kala-azar dermal leishmaniasis (67896006); PKDL - Post-Kala-azar dermal leishmanioid (67896006); Post-Kala-azar dermal leishmanioid (67896006)

Definition

A cutaneous form of leishmaniasis which sometimes occurs after visceral leishmaniasis treatment. It is characterized by hypo-pigmented macules, papules, plaques, nodules, or facial erythema; and is considered to be a durable infection reservoir for visceral leishmaniasis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPost-kala-azar dermal leishmaniasis

Professional guidelines

PubMed

Mazire P, Agarwal V, Roy A
Drug Dev Res 2022 Apr;83(2):317-327. Epub 2021 Dec 28 doi: 10.1002/ddr.21907. PMID: 34962315
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Saleem MD, Oussedik E, Picardo M, Schoch JJ
J Am Acad Dermatol 2019 May;80(5):1233-1250.e10. Epub 2018 Sep 17 doi: 10.1016/j.jaad.2018.07.070. PMID: 30236514

Recent clinical studies

Etiology

Grifferty G, Shirley H, O'Brien K, Hirsch JL, Orriols AM, Amechi KL, Lo J, Chanda N, El Hamzaoui S, Kahn J, Yap SV, Watson KE, Curran C, Atef AbdelAlim A, Bose N, Cilfone AL, Wamai R
PLoS Negl Trop Dis 2023 Jun;17(6):e0011358. Epub 2023 Jun 1 doi: 10.1371/journal.pntd.0011358. PMID: 37262045Free PMC Article
Volpedo G, Pacheco-Fernandez T, Holcomb EA, Cipriano N, Cox B, Satoskar AR
Front Cell Infect Microbiol 2021;11:685296. Epub 2021 Jun 8 doi: 10.3389/fcimb.2021.685296. PMID: 34169006Free PMC Article
Moulik S, Sengupta S, Chatterjee M
Front Cell Infect Microbiol 2021;11:623437. Epub 2021 Feb 22 doi: 10.3389/fcimb.2021.623437. PMID: 33692966Free PMC Article
Zijlstra EE
Parasit Vectors 2016 Aug 23;9(1):464. doi: 10.1186/s13071-016-1721-0. PMID: 27553063Free PMC Article
Singh S, Sharma U, Mishra J
Int J Dermatol 2011 Sep;50(9):1099-108. doi: 10.1111/j.1365-4632.2011.04925.x. PMID: 22126871

Diagnosis

Pathania YS, Budania A
QJM 2022 Jan 5;114(11):824-825. doi: 10.1093/qjmed/hcab236. PMID: 34499181
Zijlstra EE
Front Cell Infect Microbiol 2019;9:228. Epub 2019 Jul 31 doi: 10.3389/fcimb.2019.00228. PMID: 31417876Free PMC Article
Saleem MD, Oussedik E, Picardo M, Schoch JJ
J Am Acad Dermatol 2019 May;80(5):1233-1250.e10. Epub 2018 Sep 17 doi: 10.1016/j.jaad.2018.07.070. PMID: 30236514
Zijlstra EE, Musa AM, Khalil EA, el-Hassan IM, el-Hassan AM
Lancet Infect Dis 2003 Feb;3(2):87-98. doi: 10.1016/s1473-3099(03)00517-6. PMID: 12560194
Grevelink SA, Lerner EA
J Am Acad Dermatol 1996 Feb;34(2 Pt 1):257-72. doi: 10.1016/s0190-9622(96)80121-6. PMID: 8642091

Therapy

Gedda MR, Singh B, Kumar D, Singh AK, Madhukar P, Upadhyay S, Singh OP, Sundar S
PLoS Negl Trop Dis 2020 Jul;14(7):e0008221. Epub 2020 Jul 2 doi: 10.1371/journal.pntd.0008221. PMID: 32614818Free PMC Article
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Pradhan A, Basak S, Chowdhury T, Mohanta A, Chatterjee A
Cornea 2018 Jan;37(1):113-115. doi: 10.1097/ICO.0000000000001396. PMID: 29040115
Mukhopadhyay D, Dalton JE, Kaye PM, Chatterjee M
Trends Parasitol 2014 Feb;30(2):65-74. Epub 2014 Jan 2 doi: 10.1016/j.pt.2013.12.004. PMID: 24388776Free PMC Article
Mondal D, Khan MG
Curr Opin Infect Dis 2011 Oct;24(5):418-22. doi: 10.1097/QCO.0b013e32834a8ba1. PMID: 21885919

Prognosis

Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Mondal D, Khan MG
Curr Opin Infect Dis 2011 Oct;24(5):418-22. doi: 10.1097/QCO.0b013e32834a8ba1. PMID: 21885919
Ganguly S, Das NK, Barbhuiya JN, Chatterjee M
Int J Dermatol 2010 Aug;49(8):921-31. doi: 10.1111/j.1365-4632.2010.04558.x. PMID: 21128917
Zijlstra EE, Musa AM, Khalil EA, el-Hassan IM, el-Hassan AM
Lancet Infect Dis 2003 Feb;3(2):87-98. doi: 10.1016/s1473-3099(03)00517-6. PMID: 12560194
Ramesh V, Mukherjee A
Int J Dermatol 1995 Feb;34(2):85-91. doi: 10.1111/j.1365-4362.1995.tb03584.x. PMID: 7737782

Clinical prediction guides

Volpedo G, Pacheco-Fernandez T, Holcomb EA, Cipriano N, Cox B, Satoskar AR
Front Cell Infect Microbiol 2021;11:685296. Epub 2021 Jun 8 doi: 10.3389/fcimb.2021.685296. PMID: 34169006Free PMC Article
Gedda MR, Singh B, Kumar D, Singh AK, Madhukar P, Upadhyay S, Singh OP, Sundar S
PLoS Negl Trop Dis 2020 Jul;14(7):e0008221. Epub 2020 Jul 2 doi: 10.1371/journal.pntd.0008221. PMID: 32614818Free PMC Article
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Ganguly S, Das NK, Barbhuiya JN, Chatterjee M
Int J Dermatol 2010 Aug;49(8):921-31. doi: 10.1111/j.1365-4632.2010.04558.x. PMID: 21128917
Zijlstra EE, Musa AM, Khalil EA, el-Hassan IM, el-Hassan AM
Lancet Infect Dis 2003 Feb;3(2):87-98. doi: 10.1016/s1473-3099(03)00517-6. PMID: 12560194

Recent systematic reviews

Pires M, Wright B, Kaye PM, da Conceição V, Churchill RC
PLoS One 2019;14(10):e0223313. Epub 2019 Oct 17 doi: 10.1371/journal.pone.0223313. PMID: 31622369Free PMC Article
Kip AE, Balasegaram M, Beijnen JH, Schellens JH, de Vries PJ, Dorlo TP
Antimicrob Agents Chemother 2015 Jan;59(1):1-14. Epub 2014 Nov 3 doi: 10.1128/AAC.04298-14. PMID: 25367913Free PMC Article
Badaró R, Gonçalves LO, Gois LL, Maia ZP, Benson C, Grassi MF
J Int Assoc Provid AIDS Care 2015 Sep-Oct;14(5):402-7. Epub 2014 Oct 20 doi: 10.1177/2325957414555225. PMID: 25331225Free PMC Article
Singh S
Int J Infect Dis 2014 Dec;29:103-12. Epub 2014 Oct 22 doi: 10.1016/j.ijid.2014.07.011. PMID: 25449244
Bern C, Courtenay O, Alvar J
PLoS Negl Trop Dis 2010 Feb 9;4(2):e599. doi: 10.1371/journal.pntd.0000599. PMID: 20161727Free PMC Article

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