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Leishmaniasis

MedGen UID:
9714
Concept ID:
C0023281
Disease or Syndrome
Synonyms: Infection, Leishmania; Infections, Leishmania; Leishmania Infection; Leishmania Infections; Leishmaniases
SNOMED CT: Leishmaniasis (80612004); Leishmaniosis (80612004)
Modes of inheritance:
Not genetically inherited
MedGen UID:
988794
Concept ID:
CN307044
Finding
Source: Orphanet
clinical entity without genetic inheritance.
 
Monarch Initiative: MONDO:0011989
Orphanet: ORPHA507

Definition

A parasitic disease caused by different species of the genus <i>Leishmania</i>, transmitted through the bite of hematophagous female phlebotomine sand flies. The clinical spectrum ranges from asymptomatic to clinically overt disease which can remain localized to the skin or disseminate to the upper oral and respiratory mucous membranes or throughout the reticulo-endothelial system. Three main clinical syndromes have been described: visceral (or Kala-Azar; with fever, weight loss, hepatosplenomegaly), cutaneous, and mucocutaneous leishmaniasis (cutaneous or mucocutaneous ulceration). [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeishmaniasis
Follow this link to review classifications for Leishmaniasis in Orphanet.

Professional guidelines

PubMed

de Vries HJC, Schallig HD
Am J Clin Dermatol 2022 Nov;23(6):823-840. Epub 2022 Sep 14 doi: 10.1007/s40257-022-00726-8. PMID: 36103050Free PMC Article
Pradhan S, Schwartz RA, Patil A, Grabbe S, Goldust M
Clin Exp Dermatol 2022 Mar;47(3):516-521. Epub 2021 Oct 20 doi: 10.1111/ced.14919. PMID: 34480806
McGwire BS, Satoskar AR
QJM 2014 Jan;107(1):7-14. Epub 2013 Jun 5 doi: 10.1093/qjmed/hct116. PMID: 23744570Free PMC Article

Recent clinical studies

Etiology

de Vries HJC, Schallig HD
Am J Clin Dermatol 2022 Nov;23(6):823-840. Epub 2022 Sep 14 doi: 10.1007/s40257-022-00726-8. PMID: 36103050Free PMC Article
Bharati K
Infect Genet Evol 2022 Mar;98:105203. Epub 2022 Jan 4 doi: 10.1016/j.meegid.2021.105203. PMID: 34990851
Mahender T, Pankaj W, Kumar SP, Ankur V, Kumar SS
Mini Rev Med Chem 2022;22(5):743-757. doi: 10.2174/1389557521666210913115116. PMID: 34517799
McGwire BS, Satoskar AR
QJM 2014 Jan;107(1):7-14. Epub 2013 Jun 5 doi: 10.1093/qjmed/hct116. PMID: 23744570Free PMC Article
Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S
Lancet Infect Dis 2007 Sep;7(9):581-96. doi: 10.1016/S1473-3099(07)70209-8. PMID: 17714672

Diagnosis

Crecelius EM, Burnett MW
J Spec Oper Med 2021 Spring;21(1):113-114. doi: 10.55460/IMV2-JGWD. PMID: 33721318
Müller KE, Blomberg B, Tellevik MG, Jensenius M, Fladeby C, Lier T, Sand G, Hannula R, Langeland N, Mørch K
Tidsskr Nor Laegeforen 2021 Feb 23;141(3) Epub 2021 Feb 22 doi: 10.4045/tidsskr.19.0171. PMID: 33624958
Ibarra-Meneses AV, Moreno J, Carrillo E
Trends Parasitol 2020 Jan;36(1):29-38. Epub 2019 Nov 9 doi: 10.1016/j.pt.2019.10.005. PMID: 31718888
van Griensven J, Diro E
Infect Dis Clin North Am 2019 Mar;33(1):79-99. doi: 10.1016/j.idc.2018.10.005. PMID: 30712769
David CV, Craft N
Dermatol Ther 2009 Nov-Dec;22(6):491-502. doi: 10.1111/j.1529-8019.2009.01272.x. PMID: 19889134

Therapy

van Griensven J, Diro E
Infect Dis Clin North Am 2019 Mar;33(1):79-99. doi: 10.1016/j.idc.2018.10.005. PMID: 30712769
Uliana SRB, Trinconi CT, Coelho AC
Parasitology 2018 Apr;145(4):464-480. Epub 2017 Jan 20 doi: 10.1017/S0031182016002523. PMID: 28103966
Taslimi Y, Zahedifard F, Rafati S
Parasitology 2018 Apr;145(4):497-507. Epub 2016 Dec 15 doi: 10.1017/S003118201600216X. PMID: 27974063
Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N
Cochrane Database Syst Rev 2015 Mar 6;2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. PMID: 25742878Free PMC Article
Skinner RB Jr
Dermatol Clin 2003 Apr;21(2):291-300. doi: 10.1016/s0733-8635(02)00094-3. PMID: 12757252

Prognosis

Lin Y, Fang K, Zheng Y, Wang HL, Wu J
J Travel Med 2022 May 31;29(3) doi: 10.1093/jtm/taac031. PMID: 35238925
Gianchecchi E, Montomoli E
Expert Rev Anti Infect Ther 2020 Jun;18(6):563-577. Epub 2020 Apr 17 doi: 10.1080/14787210.2020.1751611. PMID: 32249634
de Souza A, Marins DSS, Mathias SL, Monteiro LM, Yukuyama MN, Scarim CB, Löbenberg R, Bou-Chacra NA
Int J Pharm 2018 Aug 25;547(1-2):421-431. Epub 2018 Jun 8 doi: 10.1016/j.ijpharm.2018.06.018. PMID: 29886097
Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Bin Abdulhak A, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Burney P, Carapetis J, Chen H, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, De Leo D, Degenhardt L, Delossantos A, Denenberg J, Des Jarlais DC, Dharmaratne SD, Dorsey ER, Driscoll T, Duber H, Ebel B, Erwin PJ, Espindola P, Ezzati M, Feigin V, Flaxman AD, Forouzanfar MH, Fowkes FG, Franklin R, Fransen M, Freeman MK, Gabriel SE, Gakidou E, Gaspari F, Gillum RF, Gonzalez-Medina D, Halasa YA, Haring D, Harrison JE, Havmoeller R, Hay RJ, Hoen B, Hotez PJ, Hoy D, Jacobsen KH, James SL, Jasrasaria R, Jayaraman S, Johns N, Karthikeyan G, Kassebaum N, Keren A, Khoo JP, Knowlton LM, Kobusingye O, Koranteng A, Krishnamurthi R, Lipnick M, Lipshultz SE, Ohno SL, Mabweijano J, MacIntyre MF, Mallinger L, March L, Marks GB, Marks R, Matsumori A, Matzopoulos R, Mayosi BM, McAnulty JH, McDermott MM, McGrath J, Mensah GA, Merriman TR, Michaud C, Miller M, Miller TR, Mock C, Mocumbi AO, Mokdad AA, Moran A, Mulholland K, Nair MN, Naldi L, Narayan KM, Nasseri K, Norman P, O'Donnell M, Omer SB, Ortblad K, Osborne R, Ozgediz D, Pahari B, Pandian JD, Rivero AP, Padilla RP, Perez-Ruiz F, Perico N, Phillips D, Pierce K, Pope CA 3rd, Porrini E, Pourmalek F, Raju M, Ranganathan D, Rehm JT, Rein DB, Remuzzi G, Rivara FP, Roberts T, De León FR, Rosenfeld LC, Rushton L, Sacco RL, Salomon JA, Sampson U, Sanman E, Schwebel DC, Segui-Gomez M, Shepard DS, Singh D, Singleton J, Sliwa K, Smith E, Steer A, Taylor JA, Thomas B, Tleyjeh IM, Towbin JA, Truelsen T, Undurraga EA, Venketasubramanian N, Vijayakumar L, Vos T, Wagner GR, Wang M, Wang W, Watt K, Weinstock MA, Weintraub R, Wilkinson JD, Woolf AD, Wulf S, Yeh PH, Yip P, Zabetian A, Zheng ZJ, Lopez AD, Murray CJ, AlMazroa MA, Memish ZA
Lancet 2012 Dec 15;380(9859):2095-128. doi: 10.1016/S0140-6736(12)61728-0. PMID: 23245604Free PMC Article
Reithinger R, Dujardin JC, Louzir H, Pirmez C, Alexander B, Brooker S
Lancet Infect Dis 2007 Sep;7(9):581-96. doi: 10.1016/S1473-3099(07)70209-8. PMID: 17714672

Clinical prediction guides

Mahender T, Pankaj W, Kumar SP, Ankur V, Kumar SS
Mini Rev Med Chem 2022;22(5):743-757. doi: 10.2174/1389557521666210913115116. PMID: 34517799
Chakravarty J, Sundar S
Expert Opin Pharmacother 2019 Jul;20(10):1251-1265. Epub 2019 May 7 doi: 10.1080/14656566.2019.1609940. PMID: 31063412
Borghi SM, Fattori V, Conchon-Costa I, Pinge-Filho P, Pavanelli WR, Verri WA Jr
Parasitol Res 2017 Feb;116(2):465-475. Epub 2016 Dec 9 doi: 10.1007/s00436-016-5340-7. PMID: 27933392
Gharbi M, Mhadhbi M, Rejeb A, Jaouadi K, Rouatbi M, Darghouth MA
Rev Sci Tech 2015 Aug;34(2):613-26. doi: 10.20506/rst.34.2.2384. PMID: 26601461
Von Stebut E
J Dtsch Dermatol Ges 2015 Mar;13(3):191-200; quiz 201. doi: 10.1111/ddg.12595. PMID: 25721626

Recent systematic reviews

Santos FA, Cruz GS, Vieira FA, Queiroz BRS, Freitas CDT, Mesquita FP, Souza PFN
Acta Trop 2022 Dec;236:106675. Epub 2022 Aug 31 doi: 10.1016/j.actatropica.2022.106675. PMID: 36057367
Ahramiyanpour N, Shafie'ei M, Sarvipour N, Amiri R, Akbari Z
J Cosmet Dermatol 2022 May;21(5):1874-1894. Epub 2022 Feb 14 doi: 10.1111/jocd.14834. PMID: 35124882
Mignot G, Bhattacharya Y, Reddy A
Indian J Ophthalmol 2021 May;69(5):1052-1060. doi: 10.4103/ijo.IJO_2232_20. PMID: 33913831Free PMC Article
Taghipour A, Abdoli A, Ramezani A, Abolghazi A, Mofazzal Jahromi MA, Maani S, Heidar Nejadi SM, Rasti S, Shams M, Ghasemi E
Biol Trace Elem Res 2021 Oct;199(10):3918-3938. Epub 2021 Jan 6 doi: 10.1007/s12011-020-02505-0. PMID: 33405078
Jull AB, Cullum N, Dumville JC, Westby MJ, Deshpande S, Walker N
Cochrane Database Syst Rev 2015 Mar 6;2015(3):CD005083. doi: 10.1002/14651858.CD005083.pub4. PMID: 25742878Free PMC Article

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