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Leukemogenesis

MedGen UID:
109335
•Concept ID:
C0598766
•
Neoplastic Process
Synonyms: Leukemogenesis/Lymphomagenesis; Lymphomagenesis

Definition

The causation (or induction), development, and progression of a leukaemic disease. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLeukemogenesis

Professional guidelines

PubMed

Clinical Utility of Next-Generation Sequencing in Acute Myeloid Leukemia.
Yang F, Anekpuritanang T, Press RD
Mol Diagn Ther 2020 Feb;24(1):1-13. doi: 10.1007/s40291-019-00443-9. PMID: 31848884
ICUS, IDUS, CHIP and CCUS: Diagnostic Criteria, Separation from MDS and Clinical Implications.
Valent P
Pathobiology 2019;86(1):30-38. Epub 2018 Jun 1 doi: 10.1159/000489042. PMID: 29860246Free PMC Article
LGL leukemia: from pathogenesis to treatment.
Lamy T, Moignet A, Loughran TP Jr
Blood 2017 Mar 2;129(9):1082-1094. Epub 2017 Jan 23 doi: 10.1182/blood-2016-08-692590. PMID: 28115367

Recent clinical studies

Etiology

Single-cell genomics in AML: extending the frontiers of AML research.
Ediriwickrema A, Gentles AJ, Majeti R
Blood 2023 Jan 26;141(4):345-355. doi: 10.1182/blood.2021014670. PMID: 35926108Free PMC Article
Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
Recent Advances in Managing Acute Lymphoblastic Leukemia.
DeAngelo DJ, Jabbour E, Advani A
Am Soc Clin Oncol Educ Book 2020 May;40:330-342. doi: 10.1200/EDBK_280175. PMID: 32421447
The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells.
Nepstad I, Hatfield KJ, Grønningsæter IS, Reikvam H
Int J Mol Sci 2020 Apr 21;21(8) doi: 10.3390/ijms21082907. PMID: 32326335Free PMC Article
Genomics of Acute Myeloid Leukemia Diagnosis and Pathways.
Bullinger L, Döhner K, Döhner H
J Clin Oncol 2017 Mar 20;35(9):934-946. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.71.2208. PMID: 28297624

Diagnosis

All that glitters is not LGL Leukemia.
Semenzato G, Teramo A, Calabretto G, Gasparini VR, Zambello R
Leukemia 2022 Nov;36(11):2551-2557. Epub 2022 Sep 15 doi: 10.1038/s41375-022-01695-x. PMID: 36109593
Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
Clinical Utility of Next-Generation Sequencing in Acute Myeloid Leukemia.
Yang F, Anekpuritanang T, Press RD
Mol Diagn Ther 2020 Feb;24(1):1-13. doi: 10.1007/s40291-019-00443-9. PMID: 31848884
Genetic Basis of Acute Lymphoblastic Leukemia.
Iacobucci I, Mullighan CG
J Clin Oncol 2017 Mar 20;35(9):975-983. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.70.7836. PMID: 28297628Free PMC Article
Genomics of Acute Myeloid Leukemia Diagnosis and Pathways.
Bullinger L, Döhner K, Döhner H
J Clin Oncol 2017 Mar 20;35(9):934-946. Epub 2017 Feb 13 doi: 10.1200/JCO.2016.71.2208. PMID: 28297624

Therapy

Advances in acute myeloid leukemia.
Newell LF, Cook RJ
BMJ 2021 Oct 6;375:n2026. doi: 10.1136/bmj.n2026. PMID: 34615640
Novel therapies for AML: a round-up for clinicians.
Swaminathan M, Wang ES
Expert Rev Clin Pharmacol 2020 Dec;13(12):1389-1400. Epub 2021 Jan 7 doi: 10.1080/17512433.2020.1850255. PMID: 33412978
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M
Int J Mol Med 2020 Feb;45(2):279-297. Epub 2019 Dec 4 doi: 10.3892/ijmm.2019.4418. PMID: 31894255Free PMC Article
Mutations driving CLL and their evolution in progression and relapse.
Landau DA, Tausch E, Taylor-Weiner AN, Stewart C, Reiter JG, Bahlo J, Kluth S, Bozic I, Lawrence M, Böttcher S, Carter SL, Cibulskis K, Mertens D, Sougnez CL, Rosenberg M, Hess JM, Edelmann J, Kless S, Kneba M, Ritgen M, Fink A, Fischer K, Gabriel S, Lander ES, Nowak MA, Döhner H, Hallek M, Neuberg D, Getz G, Stilgenbauer S, Wu CJ
Nature 2015 Oct 22;526(7574):525-30. Epub 2015 Oct 14 doi: 10.1038/nature15395. PMID: 26466571Free PMC Article
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
Lindsley RC, Mar BG, Mazzola E, Grauman PV, Shareef S, Allen SL, Pigneux A, Wetzler M, Stuart RK, Erba HP, Damon LE, Powell BL, Lindeman N, Steensma DP, Wadleigh M, DeAngelo DJ, Neuberg D, Stone RM, Ebert BL
Blood 2015 Feb 26;125(9):1367-76. Epub 2014 Dec 30 doi: 10.1182/blood-2014-11-610543. PMID: 25550361Free PMC Article

Prognosis

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.
Hu CL, Chen BY, Li Z, Yang T, Xu CH, Yang R, Yu PC, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei MY, Zong LJ, Zhang JY, Wu JC, Chen SB, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng CH, Ren YY, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu LY, Chang CK, Shen S, Chen Z, Chen SJ, Liu X, Sun XJ, Zheng M, Wang L
Cell Res 2022 Dec;32(12):1105-1123. Epub 2022 Oct 27 doi: 10.1038/s41422-022-00735-6. PMID: 36302855Free PMC Article
Clinical Utility of Next-Generation Sequencing in Acute Myeloid Leukemia.
Yang F, Anekpuritanang T, Press RD
Mol Diagn Ther 2020 Feb;24(1):1-13. doi: 10.1007/s40291-019-00443-9. PMID: 31848884
Epigenetics in pediatric acute lymphoblastic leukemia.
Nordlund J, Syvänen AC
Semin Cancer Biol 2018 Aug;51:129-138. Epub 2017 Sep 5 doi: 10.1016/j.semcancer.2017.09.001. PMID: 28887175
The Philadelphia chromosome in leukemogenesis.
Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q
Chin J Cancer 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. PMID: 27233483Free PMC Article
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.
Lindsley RC, Mar BG, Mazzola E, Grauman PV, Shareef S, Allen SL, Pigneux A, Wetzler M, Stuart RK, Erba HP, Damon LE, Powell BL, Lindeman N, Steensma DP, Wadleigh M, DeAngelo DJ, Neuberg D, Stone RM, Ebert BL
Blood 2015 Feb 26;125(9):1367-76. Epub 2014 Dec 30 doi: 10.1182/blood-2014-11-610543. PMID: 25550361Free PMC Article

Clinical prediction guides

Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.
Hu CL, Chen BY, Li Z, Yang T, Xu CH, Yang R, Yu PC, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei MY, Zong LJ, Zhang JY, Wu JC, Chen SB, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng CH, Ren YY, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu LY, Chang CK, Shen S, Chen Z, Chen SJ, Liu X, Sun XJ, Zheng M, Wang L
Cell Res 2022 Dec;32(12):1105-1123. Epub 2022 Oct 27 doi: 10.1038/s41422-022-00735-6. PMID: 36302855Free PMC Article
The PI3K-Akt-mTOR Signaling Pathway in Human Acute Myeloid Leukemia (AML) Cells.
Nepstad I, Hatfield KJ, Grønningsæter IS, Reikvam H
Int J Mol Sci 2020 Apr 21;21(8) doi: 10.3390/ijms21082907. PMID: 32326335Free PMC Article
The cell of origin and the leukemia stem cell in acute myeloid leukemia.
Chopra M, Bohlander SK
Genes Chromosomes Cancer 2019 Dec;58(12):850-858. Epub 2019 Aug 31 doi: 10.1002/gcc.22805. PMID: 31471945
Causes and Consequences of Hematopoietic Stem Cell Heterogeneity.
Haas S, Trumpp A, Milsom MD
Cell Stem Cell 2018 May 3;22(5):627-638. doi: 10.1016/j.stem.2018.04.003. PMID: 29727678
The Philadelphia chromosome in leukemogenesis.
Kang ZJ, Liu YF, Xu LZ, Long ZJ, Huang D, Yang Y, Liu B, Feng JX, Pan YJ, Yan JS, Liu Q
Chin J Cancer 2016 May 27;35:48. doi: 10.1186/s40880-016-0108-0. PMID: 27233483Free PMC Article

Recent systematic reviews

Monosomy 7/del (7q) in inherited bone marrow failure syndromes: A systematic review.
Pezeshki A, Podder S, Kamel R, Corey SJ
Pediatr Blood Cancer 2017 Dec;64(12) Epub 2017 Jul 14 doi: 10.1002/pbc.26714. PMID: 28708320Free PMC Article
Parental alcohol consumption and risk of leukemia in the offspring: a systematic review and meta-analysis.
Karalexi MA, Dessypris N, Thomopoulos TP, Ntouvelis E, Kantzanou M, Diamantaras AA, Moschovi M, Baka M, Hatzipantelis E, Kourti M, Polychronopoulou S, Stiakaki E, Mora AM, Wunsch-Filho V, Infante-Rivard C, Loutradis D, Petridou ET
Eur J Cancer Prev 2017 Sep;26(5):433-441. doi: 10.1097/CEJ.0000000000000350. PMID: 28379884
Association of maternal and index child's diet with subsequent leukemia risk: A systematic review and meta analysis.
Dessypris N, Karalexi MA, Ntouvelis E, Diamantaras AA, Papadakis V, Baka M, Hatzipantelis E, Kourti M, Moschovi M, Polychronopoulou S, Sidi V, Stiakaki E, Petridou ET
Cancer Epidemiol 2017 Apr;47:64-75. Epub 2017 Jan 25 doi: 10.1016/j.canep.2017.01.003. PMID: 28130996
The role of cytokines in acute myeloid leukemia: a systematic review.
Kupsa T, Horacek JM, Jebavy L
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2012 Dec;156(4):291-301. Epub 2012 Dec 7 doi: 10.5507/bp.2012.108. PMID: 23223353
Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis.
Ye Z, Song H
Eur J Cancer 2005 May;41(7):980-9. doi: 10.1016/j.ejca.2005.01.014. PMID: 15862746

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