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Warthin tumor

MedGen UID:: 124
•Concept ID:: C0001429
•: Neoplastic Process

Synonym:	Papillary cystadenoma lymphomatosum (formerly)
SNOMED CT:	Adenolymphoma (422470007); Papillary cystadenoma lymphomatosum (422470007); Warthin's tumor (422470007); Adenolymphoma (20776008); Papillary cystadenoma lymphomatosum (20776008); Warthin's tumor (20776008)

Monarch Initiative:	MONDO:0006493

Definition

An adenoma characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid gland, and is the second most common benign parotid salivary gland tumor. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVWarthin tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Adenoma
        Warthin tumor
        Lacrimal Gland Warthin Tumor
        Parotid Gland Warthin Tumor

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259 Free PMC Article

Utility of clinical features with fine needle aspiration biopsy for diagnosis of Warthin tumor.

So T, Sahovaler A, Nichols A, Fung K, Yoo J, Weir MM, MacNeil SD
J Otolaryngol Head Neck Surg 2019 Aug 29;48(1):41. doi: 10.1186/s40463-019-0366-3. PMID: 31464652 Free PMC Article

If cytology of Warthin tumor is accurate, can management be conservative?

Vlantis AC, Ng SK, Mak CK, Cheung JM, Chan AB, van Hasselt CA
Ear Nose Throat J 2016 Apr-May;95(4-5):185-8. PMID: 27140020

See all (7)

Recent clinical studies

Etiology

Pitfalls in Salivary Gland Cytology.

Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Clinicopathological features of incidental parotid lesions.

Al-Balas H, Metwalli ZA, Eberson S, Sada DM
Head Face Med 2021 Mar 23;17(1):10. doi: 10.1186/s13005-021-00262-6. PMID: 33757536 Free PMC Article

Sebaceous Lymphadenoma: Radiology-Pathology Correlation.

Dababneh MN, Griffith CC, Patel MR, Magliocca KR
Head Neck Pathol 2021 Jun;15(2):593-598. Epub 2021 Jan 4 doi: 10.1007/s12105-020-01266-5. PMID: 33398686 Free PMC Article

Benign Parotid Tumors.

Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

See all (108)

Diagnosis

Warthin-like mucoepidermoid carcinoma of the parotid gland: Clinicopathological observation and literature review.

Yan L, Xu J, Liu L, Li X
Sci Prog 2023 Apr-Jun;106(2):368504231179816. doi: 10.1177/00368504231179816. PMID: 37335119 Free PMC Article

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Recurrent Benign Salivary Gland Neoplasms.

Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Benign Parotid Tumors.

Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Intraparotid schwannoma.

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

See all (173)

Therapy

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor.

Lee JY, Kim HJ, Kim YK, Cha J, Kim ST
Diagn Interv Radiol 2019 Jul;25(4):285-290. doi: 10.5152/dir.2019.18337. PMID: 31120425 Free PMC Article

Surgical treatment strategy in Warthin tumor of the parotid gland.

Lee DH, Yoon TM, Lee JK, Lim SC
Braz J Otorhinolaryngol 2019 Sep-Oct;85(5):546-550. Epub 2018 May 16 doi: 10.1016/j.bjorl.2018.04.004. PMID: 29807810 Free PMC Article

Diagnostic accuracy of fine-needle aspiration cytology in Warthin tumors.

Veder LL, Kerrebijn JD, Smedts FM, den Bakker MA
Head Neck 2010 Dec;32(12):1635-40. doi: 10.1002/hed.21382. PMID: 20848407

See all (19)

Prognosis

Pitfalls in Salivary Gland Cytology.

Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

Incidental finding of upper lip Warthin tumor.

Petrocelli M, Sbordone C, Salzano G, Orabona GD, Cassandro FM, Fusetti S, Califano L, Cassandro E
Ann Ital Chir 2017 Nov 14;6 PMID: 29134953

Recurrent Benign Salivary Gland Neoplasms.

Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Intraparotid schwannoma.

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

See all (59)

Clinical prediction guides

Pitfalls in Salivary Gland Cytology.

Saoud C, Bailey GE, Graham A, Bonilla LM, Sanchez SI, Maleki Z
Acta Cytol 2024;68(3):194-205. Epub 2024 Feb 28 doi: 10.1159/000538069. PMID: 38417405

Warthin-like mucoepidermoid carcinoma of the parotid gland: Clinicopathological observation and literature review.

Yan L, Xu J, Liu L, Li X
Sci Prog 2023 Apr-Jun;106(2):368504231179816. doi: 10.1177/00368504231179816. PMID: 37335119 Free PMC Article

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

Recurrent Benign Salivary Gland Neoplasms.

Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Intraparotid schwannoma.

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

See all (71)