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Warthin tumor

MedGen UID:: 124
•Concept ID:: C0001429
•: Neoplastic Process

Synonym:	Papillary cystadenoma lymphomatosum (formerly)
SNOMED CT:	Adenolymphoma (422470007); Papillary cystadenoma lymphomatosum (422470007); Warthin's tumor (422470007); Adenolymphoma (20776008); Papillary cystadenoma lymphomatosum (20776008); Warthin's tumor (20776008)

Monarch Initiative:	MONDO:0006493

Definition

An adenoma characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid gland, and is the second most common benign parotid salivary gland tumor. A strong association with smoking has been reported. It typically presents as a painless swelling in the lower portion of the parotid gland. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVWarthin tumor

Pathological Conditions, Signs and Symptoms
- Pathological process
  - Disease
    - Neoplasm
      - Epithelial neoplasm
        Adenoma
        Warthin tumor
        Lacrimal Gland Warthin Tumor
        Parotid Gland Warthin Tumor

Professional guidelines

PubMed

Oncocytoid Salivary Tumors: Differential Diagnosis and Utility of Newly Described Immunohistochemistry.

Katabi N
Head Neck Pathol 2024 Mar 19;18(1):20. doi: 10.1007/s12105-024-01622-9. PMID: 38502259 Free PMC Article

Utility of clinical features with fine needle aspiration biopsy for diagnosis of Warthin tumor.

So T, Sahovaler A, Nichols A, Fung K, Yoo J, Weir MM, MacNeil SD
J Otolaryngol Head Neck Surg 2019 Aug 29;48(1):41. doi: 10.1186/s40463-019-0366-3. PMID: 31464652 Free PMC Article

If cytology of Warthin tumor is accurate, can management be conservative?

Vlantis AC, Ng SK, Mak CK, Cheung JM, Chan AB, van Hasselt CA
Ear Nose Throat J 2016 Apr-May;95(4-5):185-8. PMID: 27140020

See all (7)

Recent clinical studies

Etiology

A retrospective study of nonneoplastic and neoplastic disorders of the salivary glands.

Vamesu S, Ursica OA, Gurita AM, Voda RI, Deacu M, Aschie M, Bosoteanu M, Cozaru GC, Mitroi AF, Orasanu CI
Medicine (Baltimore) 2023 Oct 20;102(42):e35751. doi: 10.1097/MD.0000000000035751. PMID: 37861511 Free PMC Article

Warthin Tumor of the Parotid Gland: The History of an Eponym.

Ide F, Sakamoto S, Miyazaki Y, Nishimura M, Ito Y, Muramatsu T, Kikuchi K
Head Neck Pathol 2023 Sep;17(3):775-781. Epub 2023 May 25 doi: 10.1007/s12105-023-01559-5. PMID: 37227678 Free PMC Article

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Benign Parotid Tumors.

Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

See all (104)

Diagnosis

Top Ten Oncocytic Head and Neck Lesions to Contemplate.

Bullock MJ, Jiang XS
Head Neck Pathol 2023 Mar;17(1):53-65. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01520-y. PMID: 36928735 Free PMC Article

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Cytomorphological findings in diagnosis of Warthin tumor.

Köybaşioğlu FF, Önal B, Han Ü, Adabağ A, Şahpaz A
Turk J Med Sci 2020 Feb 13;50(1):148-154. doi: 10.3906/sag-1901-215. PMID: 31769640 Free PMC Article

Benign Parotid Tumors.

Zhan KY, Khaja SF, Flack AB, Day TA
Otolaryngol Clin North Am 2016 Apr;49(2):327-42. doi: 10.1016/j.otc.2015.10.005. PMID: 27040584

Intraparotid schwannoma.

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

See all (167)

Therapy

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

Cytologic diagnosis of parotid gland Warthin tumor: Systematic review and meta-analysis.

Fisher R, Ronen O
Head Neck 2022 Oct;44(10):2277-2287. Epub 2022 May 18 doi: 10.1002/hed.27099. PMID: 35586869 Free PMC Article

Basal cell adenoma and myoepithelioma of the parotid gland: patterns of enhancement at two-phase CT in comparison with Warthin tumor.

Lee JY, Kim HJ, Kim YK, Cha J, Kim ST
Diagn Interv Radiol 2019 Jul;25(4):285-290. doi: 10.5152/dir.2019.18337. PMID: 31120425 Free PMC Article

Surgical treatment strategy in Warthin tumor of the parotid gland.

Lee DH, Yoon TM, Lee JK, Lim SC
Braz J Otorhinolaryngol 2019 Sep-Oct;85(5):546-550. Epub 2018 May 16 doi: 10.1016/j.bjorl.2018.04.004. PMID: 29807810 Free PMC Article

Identification of Warthin tumor: magnetic resonance imaging versus salivary scintigraphy with technetium-99m pertechnetate.

Motoori K, Ueda T, Uchida Y, Chazono H, Suzuki H, Ito H
J Comput Assist Tomogr 2005 Jul-Aug;29(4):506-12. doi: 10.1097/01.rct.0000164672.34261.33. PMID: 16012309

See all (19)

Prognosis

Value of T2-weighted-based radiomics model in distinguishing Warthin tumor from pleomorphic adenoma of the parotid.

Hu Z, Guo J, Feng J, Huang Y, Xu H, Zhou Q
Eur Radiol 2023 Jun;33(6):4453-4463. Epub 2022 Dec 11 doi: 10.1007/s00330-022-09295-0. PMID: 36502461

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

The significance of mucinous metaplasia in Warthin tumor: a frequent occurrence and potential pitfall.

Zhang X, Baloch ZW, Cooper K, Zhang PJ, Puthiyaveettil R, LiVolsi VA
Hum Pathol 2020 May;99:13-26. Epub 2020 Mar 26 doi: 10.1016/j.humpath.2020.03.008. PMID: 32223989

Recurrent Benign Salivary Gland Neoplasms.

Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Intraparotid schwannoma.

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

See all (57)

Clinical prediction guides

A retrospective study of nonneoplastic and neoplastic disorders of the salivary glands.

Distinguishing Parotid Polymorphic Adenoma and Warthin Tumor Based on the CT Radiomics Nomogram: A Multicenter Study.

Feng B, Wang Z, Cui J, Li J, Xu H, Yu D, Zeng Q, Xiu J
Acad Radiol 2023 Apr;30(4):717-726. Epub 2022 Aug 8 doi: 10.1016/j.acra.2022.06.017. PMID: 35953356

Xanthogranulomatous Sialadenitis, an Uncommon Reactive Change is Often Associated with Warthin's Tumor.

Bu L, Zhu H, Racila E, Khaja S, Hamlar D, Li F
Head Neck Pathol 2020 Jun;14(2):525-532. Epub 2019 Aug 31 doi: 10.1007/s12105-019-01066-6. PMID: 31473936 Free PMC Article

Recurrent Benign Salivary Gland Neoplasms.

Witt RL, Nicolai P
Adv Otorhinolaryngol 2016;78:63-70. Epub 2016 Apr 12 doi: 10.1159/000442126. PMID: 27093568

Intraparotid schwannoma.

McCarthy WA, Cox BL
Arch Pathol Lab Med 2014 Jul;138(7):982-5. doi: 10.5858/arpa.2013-0014-RS. PMID: 24978928

See all (66)