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Polyp of middle ear

MedGen UID:
124403
•Concept ID:
C0271466
•
Neoplastic Process
Synonyms: Aural polyp of middle ear; Middle Ear Polyp; middle Ear polyp; middle ear polyp; polyp - middle ear; Polyp of Middle Ear; polyp of middle ear; Polyp of the Middle Ear; polyp of the middle ear
SNOMED CT: Polyp of middle ear (73103007); Aural polyp of middle ear (73103007)
 
Monarch Initiative: MONDO:0004223

Definition

A benign polypoid growth in the middle ear. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVPolyp of middle ear

Professional guidelines

PubMed

Intractable otitis media - Pathogenesis and treatment of Eosinophilic otitis media (EOM) and otitis media with Antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (OMAAV).
Yoshida N
Auris Nasus Larynx 2023 Apr;50(2):171-179. Epub 2022 Aug 5 doi: 10.1016/j.anl.2022.07.005. PMID: 35934599
Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence?
Kuan EC, Kovacs AJ, Workman AD, Bosso JV, Adappa ND
Int Forum Allergy Rhinol 2019 May;9(S1):S16-S21. doi: 10.1002/alr.22340. PMID: 31087635
Diagnosis and management of chronic rhinosinusitis in adults.
Marple BF, Stankiewicz JA, Baroody FM, Chow JM, Conley DB, Corey JP, Ferguson BJ, Kern RC, Lusk RP, Naclerio RM, Orlandi RR, Parker MJ; American Academy of Otolaryngic Allergy Working Group on Chronic Rhinosinusitis
Postgrad Med 2009 Nov;121(6):121-39. doi: 10.3810/pgm.2009.11.2081. PMID: 19940423

Recent clinical studies

Etiology

Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps.
Mueller SK, Wendler O, Mayr S, Traxdorf M, Koch M, Mantsopoulos K, Sievert M, Grundtner P, Iro H, Bleier BS
Int Forum Allergy Rhinol 2024 May;14(5):887-897. Epub 2023 Nov 22 doi: 10.1002/alr.23295. PMID: 37990964
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.
Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, Mullol J, Greos LS, Bosso JV, Laidlaw TM, Cervin AU, Maspero JF, Hopkins C, Olze H, Canonica GW, Paggiaro P, Cho SH, Fokkens WJ, Fujieda S, Zhang M, Lu X, Fan C, Draikiwicz S, Kamat SA, Khan A, Pirozzi G, Patel N, Graham NMH, Ruddy M, Staudinger H, Weinreich D, Stahl N, Yancopoulos GD, Mannent LP
Lancet 2019 Nov 2;394(10209):1638-1650. Epub 2019 Sep 19 doi: 10.1016/S0140-6736(19)31881-1. PMID: 31543428
Middle ear function in sinonasal polyposis.
Bakhshaee M, Ardakani HP, Ghazizadeh AH, Movahed R, Jarahi L, Rajati M
Eur Arch Otorhinolaryngol 2016 Oct;273(10):2911-6. Epub 2015 Oct 31 doi: 10.1007/s00405-015-3812-5. PMID: 26521187
A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy.
Wright A, Hawkins CH, Anggård EE, Harper DR
Clin Otolaryngol 2009 Aug;34(4):349-57. doi: 10.1111/j.1749-4486.2009.01973.x. PMID: 19673983
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438

Diagnosis

Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps.
Mueller SK, Wendler O, Mayr S, Traxdorf M, Koch M, Mantsopoulos K, Sievert M, Grundtner P, Iro H, Bleier BS
Int Forum Allergy Rhinol 2024 May;14(5):887-897. Epub 2023 Nov 22 doi: 10.1002/alr.23295. PMID: 37990964
A whiff of trouble: tumours of the nasal cavity and their mimics.
Szewczyk-Bieda MJ, White RD, Budak MJ, Ananthakrishnan G, Brunton JN, Sudarshan TA
Clin Radiol 2014 May;69(5):519-28. Epub 2014 Feb 11 doi: 10.1016/j.crad.2013.12.004. PMID: 24525221
Diagnosis and management of chronic rhinosinusitis in adults.
Marple BF, Stankiewicz JA, Baroody FM, Chow JM, Conley DB, Corey JP, Ferguson BJ, Kern RC, Lusk RP, Naclerio RM, Orlandi RR, Parker MJ; American Academy of Otolaryngic Allergy Working Group on Chronic Rhinosinusitis
Postgrad Med 2009 Nov;121(6):121-39. doi: 10.3810/pgm.2009.11.2081. PMID: 19940423
A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy.
Wright A, Hawkins CH, Anggård EE, Harper DR
Clin Otolaryngol 2009 Aug;34(4):349-57. doi: 10.1111/j.1749-4486.2009.01973.x. PMID: 19673983
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438

Therapy

Mepolizumab improves sense of smell in severe chronic rhinosinusitis with nasal polyps: SYNAPSE.
Mullol J, Lund VJ, Wagenmann M, Han JK, Sousa AN, Smith SG, Mayer B, Chan RH, Fokkens WJ
Rhinology 2024 Jun 1;62(3):320-329. doi: 10.4193/Rhin22.416. PMID: 38217844
Intractable otitis media - Pathogenesis and treatment of Eosinophilic otitis media (EOM) and otitis media with Antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (OMAAV).
Yoshida N
Auris Nasus Larynx 2023 Apr;50(2):171-179. Epub 2022 Aug 5 doi: 10.1016/j.anl.2022.07.005. PMID: 35934599
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.
Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, Mullol J, Greos LS, Bosso JV, Laidlaw TM, Cervin AU, Maspero JF, Hopkins C, Olze H, Canonica GW, Paggiaro P, Cho SH, Fokkens WJ, Fujieda S, Zhang M, Lu X, Fan C, Draikiwicz S, Kamat SA, Khan A, Pirozzi G, Patel N, Graham NMH, Ruddy M, Staudinger H, Weinreich D, Stahl N, Yancopoulos GD, Mannent LP
Lancet 2019 Nov 2;394(10209):1638-1650. Epub 2019 Sep 19 doi: 10.1016/S0140-6736(19)31881-1. PMID: 31543428
Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence?
Kuan EC, Kovacs AJ, Workman AD, Bosso JV, Adappa ND
Int Forum Allergy Rhinol 2019 May;9(S1):S16-S21. doi: 10.1002/alr.22340. PMID: 31087635
A controlled clinical trial of a therapeutic bacteriophage preparation in chronic otitis due to antibiotic-resistant Pseudomonas aeruginosa; a preliminary report of efficacy.
Wright A, Hawkins CH, Anggård EE, Harper DR
Clin Otolaryngol 2009 Aug;34(4):349-57. doi: 10.1111/j.1749-4486.2009.01973.x. PMID: 19673983

Prognosis

Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps.
Mueller SK, Wendler O, Mayr S, Traxdorf M, Koch M, Mantsopoulos K, Sievert M, Grundtner P, Iro H, Bleier BS
Int Forum Allergy Rhinol 2024 May;14(5):887-897. Epub 2023 Nov 22 doi: 10.1002/alr.23295. PMID: 37990964
Intractable otitis media - Pathogenesis and treatment of Eosinophilic otitis media (EOM) and otitis media with Antineutrophil cytoplasmic antibody (ANCA) -associated vasculitis (OMAAV).
Yoshida N
Auris Nasus Larynx 2023 Apr;50(2):171-179. Epub 2022 Aug 5 doi: 10.1016/j.anl.2022.07.005. PMID: 35934599
The prognostic value of subjective nasal symptoms and SNOT-22 score in middle ear surgery.
Dispenza F, Immordino A, De Stefano A, Sireci F, Lorusso F, Salvago P, Martines F, Gallina S
Am J Otolaryngol 2022 Jul-Aug;43(4):103480. Epub 2022 May 5 doi: 10.1016/j.amjoto.2022.103480. PMID: 35537229
Examination of Sex Differences in a Chronic Rhinosinusitis Surgical Cohort.
Ramos L, Massey CJ, Asokan A, Rice JD, Kroehl M, Ramakrishnan VR
Otolaryngol Head Neck Surg 2022 Sep;167(3):583-589. Epub 2022 Feb 8 doi: 10.1177/01945998221076468. PMID: 35133914
Polypoidal choroidal vasculopathy.
Ciardella AP, Donsoff IM, Huang SJ, Costa DL, Yannuzzi LA
Surv Ophthalmol 2004 Jan-Feb;49(1):25-37. doi: 10.1016/j.survophthal.2003.10.007. PMID: 14711438

Clinical prediction guides

Mepolizumab improves sense of smell in severe chronic rhinosinusitis with nasal polyps: SYNAPSE.
Mullol J, Lund VJ, Wagenmann M, Han JK, Sousa AN, Smith SG, Mayer B, Chan RH, Fokkens WJ
Rhinology 2024 Jun 1;62(3):320-329. doi: 10.4193/Rhin22.416. PMID: 38217844
Comparison of mucus and serum biomarker sampling in chronic rhinosinusitis with nasal polyps.
Mueller SK, Wendler O, Mayr S, Traxdorf M, Koch M, Mantsopoulos K, Sievert M, Grundtner P, Iro H, Bleier BS
Int Forum Allergy Rhinol 2024 May;14(5):887-897. Epub 2023 Nov 22 doi: 10.1002/alr.23295. PMID: 37990964
Clinical evaluation and nasoendoscopic scores of patients with chronic rhinosinusitis in Ilorin, Nigeria.
Ayodele SO, Afolabi OA, Segun-Busari S, Omokanye HK, Alabi BS, Ologe FE
Pan Afr Med J 2021;38:396. Epub 2021 Apr 23 doi: 10.11604/pamj.2021.38.396.26115. PMID: 34381540Free PMC Article
Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials.
Bachert C, Han JK, Desrosiers M, Hellings PW, Amin N, Lee SE, Mullol J, Greos LS, Bosso JV, Laidlaw TM, Cervin AU, Maspero JF, Hopkins C, Olze H, Canonica GW, Paggiaro P, Cho SH, Fokkens WJ, Fujieda S, Zhang M, Lu X, Fan C, Draikiwicz S, Kamat SA, Khan A, Pirozzi G, Patel N, Graham NMH, Ruddy M, Staudinger H, Weinreich D, Stahl N, Yancopoulos GD, Mannent LP
Lancet 2019 Nov 2;394(10209):1638-1650. Epub 2019 Sep 19 doi: 10.1016/S0140-6736(19)31881-1. PMID: 31543428
Efficacy of fluticasone exhalation delivery system in the management of chronic rhinosinusitis: what is the evidence?
Kuan EC, Kovacs AJ, Workman AD, Bosso JV, Adappa ND
Int Forum Allergy Rhinol 2019 May;9(S1):S16-S21. doi: 10.1002/alr.22340. PMID: 31087635

Recent systematic reviews

Eustachian tube dysfunction (ETD) in chronic rhinosinusitis with comparison to primary ETD: A systematic review and meta-analysis.
Chen T, Shih MC, Edwards TS, Nguyen SA, Meyer TA, Soler ZM, Schlosser RJ
Int Forum Allergy Rhinol 2022 Jul;12(7):942-951. Epub 2022 Jan 5 doi: 10.1002/alr.22942. PMID: 34919345
The Glasgow Benefit Inventory: a systematic review of the use and value of an otorhinolaryngological generic patient-recorded outcome measure.
Hendry J, Chin A, Swan IR, Akeroyd MA, Browning GG
Clin Otolaryngol 2016 Jun;41(3):259-75. Epub 2016 Feb 7 doi: 10.1111/coa.12518. PMID: 26264703Free PMC Article
Surgical versus medical interventions for chronic rhinosinusitis with nasal polyps.
Rimmer J, Fokkens W, Chong LY, Hopkins C
Cochrane Database Syst Rev 2014;2014(12):CD006991. Epub 2014 Dec 1 doi: 10.1002/14651858.CD006991.pub2. PMID: 25437000Free PMC Article

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