U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Lymphoid cholangitis

MedGen UID:
1376805
•Concept ID:
C4476898
•
Disease or Syndrome
HPO: HP:0030989

Definition

Cholangitis characterized by a close association between duct branches, usually interlobular bile ducts, and lymphocytic aggregates, which may show a follicular arrangement. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLymphoid cholangitis

Professional guidelines

PubMed

Histopathologic findings in lung biopsies from patients with primary biliary cholangitis.
Lee HE, Churg A, Ryu JH, Bilawich AM, Larsen BT, Tazelaar HD, Yi ES
Hum Pathol 2018 Dec;82:177-186. Epub 2018 Jul 29 doi: 10.1016/j.humpath.2018.07.021. PMID: 30067952

Recent clinical studies

Etiology

Imbalanced distribution of group 2 innate lymphoid cells (ILCs) and ILC precursors in peripheral blood of patients with primary biliary cholangitis.
Li H, Zhan H, Cheng L, Yan S, Wang L, Li Y
Scand J Immunol 2022 Jul;96(1):e13166. Epub 2022 Apr 3 doi: 10.1111/sji.13166. PMID: 35315090
NFKB1 and MANBA Confer Disease Susceptibility to Primary Biliary Cholangitis via Independent Putative Primary Functional Variants.
Hitomi Y, Nakatani K, Kojima K, Nishida N, Kawai Y, Kawashima M, Aiba Y, Nagasaki M, Nakamura M, Tokunaga K
Cell Mol Gastroenterol Hepatol 2019;7(3):515-532. Epub 2018 Dec 4 doi: 10.1016/j.jcmgh.2018.11.006. PMID: 30528300Free PMC Article
Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.
Gwela A, Siddhanathi P, Chapman RW, Travis S, Powrie F, Arancibia-Cárcamo CV, Geremia A
J Crohns Colitis 2017 Sep 1;11(9):1124-1134. doi: 10.1093/ecco-jcc/jjx050. PMID: 28383652Free PMC Article
Follicular cholangitis and pancreatitis - clinicopathological features and differential diagnosis of an under-recognized entity.
Zen Y, Ishikawa A, Ogiso S, Heaton N, Portmann B
Histopathology 2012 Jan;60(2):261-9. doi: 10.1111/j.1365-2559.2011.04078.x. PMID: 22211284
Radiology of AIDS in the pediatric patient.
Grattan-Smith D, Harrison LF, Singleton EB
Curr Probl Diagn Radiol 1992 May-Jun;21(3):79-109. doi: 10.1016/0363-0188(92)90038-h. PMID: 1576831

Diagnosis

Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.
Gwela A, Siddhanathi P, Chapman RW, Travis S, Powrie F, Arancibia-Cárcamo CV, Geremia A
J Crohns Colitis 2017 Sep 1;11(9):1124-1134. doi: 10.1093/ecco-jcc/jjx050. PMID: 28383652Free PMC Article
Increases in IgE, Eosinophils, and Mast Cells Can be Used in Diagnosis and to Predict Relapse of IgG4-Related Disease.
Culver EL, Sadler R, Bateman AC, Makuch M, Cargill T, Ferry B, Aalberse R, Barnes E, Rispens T
Clin Gastroenterol Hepatol 2017 Sep;15(9):1444-1452.e6. Epub 2017 Feb 20 doi: 10.1016/j.cgh.2017.02.007. PMID: 28223204Free PMC Article
Unmet challenges in immune-mediated hepatobiliary diseases.
Beuers U, Gershwin ME
Clin Rev Allergy Immunol 2015 Jun;48(2-3):127-31. doi: 10.1007/s12016-015-8484-9. PMID: 25820618
Liver abnormalities in connective tissue diseases.
De Santis M, Crotti C, Selmi C
Best Pract Res Clin Gastroenterol 2013 Aug;27(4):543-51. doi: 10.1016/j.bpg.2013.06.016. PMID: 24090941
Follicular cholangitis and pancreatitis - clinicopathological features and differential diagnosis of an under-recognized entity.
Zen Y, Ishikawa A, Ogiso S, Heaton N, Portmann B
Histopathology 2012 Jan;60(2):261-9. doi: 10.1111/j.1365-2559.2011.04078.x. PMID: 22211284

Therapy

The Incidence of Pouch Neoplasia Following Ileal Pouch-Anal Anastomosis in Patients With Inflammatory Bowel Disease.
Urquhart SA, Comstock BP, Jin MF, Day CN, Eaton JE, Harmsen WS, Raffals LE, Loftus EV Jr, Coelho-Prabhu N
Inflamm Bowel Dis 2024 Feb 1;30(2):183-189. doi: 10.1093/ibd/izad021. PMID: 36812365
Is PBC a viral infectious disease?
Mason AL
Best Pract Res Clin Gastroenterol 2018 Jun-Aug;34-35:27-39. Epub 2018 Jun 14 doi: 10.1016/j.bpg.2018.06.001. PMID: 30343707
Long-term Outcomes and Risk Factors After Adult Living Donor Liver Transplantation.
Imai D, Yoshizumi T, Sakata K, Ikegami T, Itoh S, Harada N, Motomura T, Toshima T, Mano Y, Soejima Y, Maehara Y
Transplantation 2018 Sep;102(9):e382-e391. doi: 10.1097/TP.0000000000002324. PMID: 29912047
Genetic Association of PTPN22 Polymorphisms with Autoimmune Hepatitis and Primary Biliary Cholangitis in Japan.
Umemura T, Joshita S, Yamazaki T, Komatsu M, Katsuyama Y, Yoshizawa K, Tanaka E, Ota M
Sci Rep 2016 Jul 11;6:29770. doi: 10.1038/srep29770. PMID: 27406031Free PMC Article
Cancer risk in cystic fibrosis: a 20-year nationwide study from the United States.
Maisonneuve P, Marshall BC, Knapp EA, Lowenfels AB
J Natl Cancer Inst 2013 Jan 16;105(2):122-9. Epub 2012 Nov 24 doi: 10.1093/jnci/djs481. PMID: 23178438

Prognosis

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression.
Guillot A, Winkler M, Silva Afonso M, Aggarwal A, Lopez D, Berger H, Kohlhepp MS, Liu H, Özdirik B, Eschrich J, Ma J, Peiseler M, Heymann F, Pendem S, Mahadevan S, Gao B, Diehl L, Gupta R, Tacke F
Hepatology 2023 Jul 1;78(1):150-166. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000270. PMID: 36630995
IgG4-related sclerosing cholangitis in the absence of autoimmune pancreatitis mimicking extrahepatic cholangiocarcinoma.
Lin J, Cummings OW, Greenson JK, House MG, Liu X, Nalbantoglu I, Pai R, Davidson DD, Reuss SA
Scand J Gastroenterol 2015 Apr;50(4):447-53. Epub 2015 Jan 30 doi: 10.3109/00365521.2014.962603. PMID: 25635498
The role of natural killer cells in autoimmune liver disease: a comprehensive review.
Hudspeth K, Pontarini E, Tentorio P, Cimino M, Donadon M, Torzilli G, Lugli E, Della Bella S, Gershwin ME, Mavilio D
J Autoimmun 2013 Oct;46:55-65. Epub 2013 Jul 21 doi: 10.1016/j.jaut.2013.07.003. PMID: 23880068
Follicular cholangitis and pancreatitis - clinicopathological features and differential diagnosis of an under-recognized entity.
Zen Y, Ishikawa A, Ogiso S, Heaton N, Portmann B
Histopathology 2012 Jan;60(2):261-9. doi: 10.1111/j.1365-2559.2011.04078.x. PMID: 22211284
IgG4-related sclerosing disease, an emerging entity: a review of a multi-system disease.
Divatia M, Kim SA, Ro JY
Yonsei Med J 2012 Jan;53(1):15-34. doi: 10.3349/ymj.2012.53.1.15. PMID: 22187229Free PMC Article

Clinical prediction guides

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression.
Guillot A, Winkler M, Silva Afonso M, Aggarwal A, Lopez D, Berger H, Kohlhepp MS, Liu H, Özdirik B, Eschrich J, Ma J, Peiseler M, Heymann F, Pendem S, Mahadevan S, Gao B, Diehl L, Gupta R, Tacke F
Hepatology 2023 Jul 1;78(1):150-166. Epub 2023 Jan 13 doi: 10.1097/HEP.0000000000000270. PMID: 36630995
Is PBC a viral infectious disease?
Mason AL
Best Pract Res Clin Gastroenterol 2018 Jun-Aug;34-35:27-39. Epub 2018 Jun 14 doi: 10.1016/j.bpg.2018.06.001. PMID: 30343707
Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.
Gwela A, Siddhanathi P, Chapman RW, Travis S, Powrie F, Arancibia-Cárcamo CV, Geremia A
J Crohns Colitis 2017 Sep 1;11(9):1124-1134. doi: 10.1093/ecco-jcc/jjx050. PMID: 28383652Free PMC Article
Liver abnormalities in connective tissue diseases.
De Santis M, Crotti C, Selmi C
Best Pract Res Clin Gastroenterol 2013 Aug;27(4):543-51. doi: 10.1016/j.bpg.2013.06.016. PMID: 24090941
Autoimmune features in metabolic liver disease: a single-center experience and review of the literature.
Tsuneyama K, Baba H, Kikuchi K, Nishida T, Nomoto K, Hayashi S, Miwa S, Nakajima T, Nakanishi Y, Masuda S, Terada M, Imura J, Selmi C
Clin Rev Allergy Immunol 2013 Aug;45(1):143-8. doi: 10.1007/s12016-013-8383-x. PMID: 23842720

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...