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Inflammatory myofibroblastic tumor

MedGen UID:
137723
Concept ID:
C0334121
Neoplastic Process
Synonyms: Inflammatory fibrosarcoma; Inflammatory pseudotumor
SNOMED CT: Myofibroblastic tumor (116064009); Inflammatory myofibroblastic tumor (116064009); Inflammatory myofibroblastic tumor (771233008); Inflammatory pseudotumor (35073002)
 
Monarch Initiative: MONDO:0015798
Orphanet: ORPHA178342

Definition

A rare neoplastic lesion of the submucosal stroma, which can develop in any organ, often occurring in the lung, mesentery, omentum and the retroperitoneal region. It is histologically heterogenous, composed of spindle-shaped cells, myofibroblasts and inflammatory cells. It is usually benign, however local invasion, recurrence, malignant transformation with vascular invasion and metastases may occur. The presentation is nonspecific and depends on the organ involved. Some patients may present with paraneoplastic syndrome (fever, malaise, weight loss, thrombocytosis) or symptoms related to compression of adjacent organs, such as bowel obstruction. [from SNOMEDCT_US]

Professional guidelines

PubMed

Fuchs J, Warmann SW, Urla C, Schäfer JF, Schmidt A
Semin Pediatr Surg 2020 Aug;29(4):150941. Epub 2020 Jul 24 doi: 10.1016/j.sempedsurg.2020.150941. PMID: 32861445
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
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Magro G
Surg Pathol Clin 2018 Mar;11(1):91-121. Epub 2017 Dec 9 doi: 10.1016/j.path.2017.09.005. PMID: 29413661

Recent clinical studies

Etiology

Carrasco Rodríguez R, García Fontán EM, Blanco Ramos M, Magdalena Benavides LJ, Otero Lozano D, Moldes Rodriguez M, Cañizares Carretero MA
Cir Esp (Engl Ed) 2022 Jun;100(6):329-335. Epub 2022 May 13 doi: 10.1016/j.cireng.2022.05.012. PMID: 35577280
Shi P, Zhang L, Shi H, Wu Y
Oncol Res Treat 2022;45(6):353-365. Epub 2022 Apr 11 doi: 10.1159/000524489. PMID: 35405683Free PMC Article
Baranov E, Hornick JL
Head Neck Pathol 2020 Mar;14(1):43-58. Epub 2020 Jan 16 doi: 10.1007/s12105-019-01104-3. PMID: 31950474Free PMC Article
Shukla PS, Mittal K
Arch Pathol Lab Med 2019 Jan;143(1):122-129. Epub 2018 Jul 2 doi: 10.5858/arpa.2017-0575-RA. PMID: 29965784
Mossé YP, Voss SD, Lim MS, Rolland D, Minard CG, Fox E, Adamson P, Wilner K, Blaney SM, Weigel BJ
J Clin Oncol 2017 Oct 1;35(28):3215-3221. Epub 2017 Aug 8 doi: 10.1200/JCO.2017.73.4830. PMID: 28787259Free PMC Article

Diagnosis

Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Kertowidjojo EC, Bennett JA
Surg Pathol Clin 2022 Jun;15(2):315-340. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.008. PMID: 35715164
Mahajan P, Casanova M, Ferrari A, Fordham A, Trahair T, Venkatramani R
Curr Probl Cancer 2021 Aug;45(4):100768. Epub 2021 Jul 1 doi: 10.1016/j.currproblcancer.2021.100768. PMID: 34244015
Barata F, Marques D, Figueiredo A
Rev Port Cir Cardiotorac Vasc 2020 Apr-Jun;27(2):79-80. PMID: 32707612
Miller DV, Tazelaar HD
Arch Pathol Lab Med 2010 Mar;134(3):362-8. doi: 10.5858/134.3.362. PMID: 20196664

Therapy

Schoot RA, Orbach D, Minard Colin V, Alaggio R, Di Carlo D, Corradini N, Mercolini F, Milano GM, van Noesel MM, Rome A, Dall'Igna P, Pajtler K, Sparber-Sauer M, Ferrari A, Casanova M
JCO Precis Oncol 2023 Sep;7:e2300323. doi: 10.1200/PO.23.00323. PMID: 37856763
Mahajan P, Casanova M, Ferrari A, Fordham A, Trahair T, Venkatramani R
Curr Probl Cancer 2021 Aug;45(4):100768. Epub 2021 Jul 1 doi: 10.1016/j.currproblcancer.2021.100768. PMID: 34244015
Theilen TM, Soerensen J, Bochennek K, Becker M, Schwabe D, Rolle U, Klingebiel T, Lehrnbecher T
Pediatr Blood Cancer 2018 Apr;65(4) Epub 2017 Dec 29 doi: 10.1002/pbc.26920. PMID: 29286567
Mossé YP, Voss SD, Lim MS, Rolland D, Minard CG, Fox E, Adamson P, Wilner K, Blaney SM, Weigel BJ
J Clin Oncol 2017 Oct 1;35(28):3215-3221. Epub 2017 Aug 8 doi: 10.1200/JCO.2017.73.4830. PMID: 28787259Free PMC Article
Minoo P, Wang HY
Int J Clin Exp Pathol 2012;5(5):397-410. Epub 2012 May 23 PMID: 22808292Free PMC Article

Prognosis

Zhang Y, Liu J
Front Endocrinol (Lausanne) 2023;14:1156117. Epub 2023 May 15 doi: 10.3389/fendo.2023.1156117. PMID: 37255972Free PMC Article
Karpathiou G, Devouassoux-Shisheboran M, Stolnicu S, Chauleur C, Péoc'h M
Pathol Res Pract 2023 Feb;242:154335. Epub 2023 Jan 23 doi: 10.1016/j.prp.2023.154335. PMID: 36706588
Shi P, Zhang L, Shi H, Wu Y
Oncol Res Treat 2022;45(6):353-365. Epub 2022 Apr 11 doi: 10.1159/000524489. PMID: 35405683Free PMC Article
Wang GY, Lucas DR
Arch Pathol Lab Med 2018 Oct;142(10):1159-1163. doi: 10.5858/arpa.2018-0205-RA. PMID: 30281365
Khatri A, Agrawal A, Sikachi RR, Mehta D, Sahni S, Meena N
Adv Respir Med 2018;86(1):27-35. doi: 10.5603/ARM.2018.0007. PMID: 29490419

Clinical prediction guides

Caporalini C, Moscardi S, Tamburini A, Pierossi N, Di Maurizio M, Buccoliero AM
Fetal Pediatr Pathol 2018 Apr;37(2):117-125. Epub 2018 Jan 16 doi: 10.1080/15513815.2017.1385667. PMID: 29336647
Mossé YP, Voss SD, Lim MS, Rolland D, Minard CG, Fox E, Adamson P, Wilner K, Blaney SM, Weigel BJ
J Clin Oncol 2017 Oct 1;35(28):3215-3221. Epub 2017 Aug 8 doi: 10.1200/JCO.2017.73.4830. PMID: 28787259Free PMC Article
Krings G, McIntire P, Shin SJ
Semin Diagn Pathol 2017 Sep;34(5):427-437. Epub 2017 May 28 doi: 10.1053/j.semdp.2017.05.010. PMID: 28751104
Ong HS, Ji T, Zhang CP, Li J, Wang LZ, Li RR, Sun J, Ma CY
Oral Oncol 2012 Feb;48(2):141-8. Epub 2011 Oct 19 doi: 10.1016/j.oraloncology.2011.09.004. PMID: 22014665
Miller DV, Tazelaar HD
Arch Pathol Lab Med 2010 Mar;134(3):362-8. doi: 10.5858/134.3.362. PMID: 20196664

Recent systematic reviews

Chanthong S, Sathitsamitphong L, Natesirinilkul R, Charoenkwan P, Suwansirikul S, Choed-Amphai C
Childs Nerv Syst 2023 Feb;39(2):331-342. Epub 2022 Dec 14 doi: 10.1007/s00381-022-05789-w. PMID: 36515740
Craig E, Wiltsie LM, Beaupin LK, Baig A, Kozielski R, Rothstein DH, Li V, Twist CJ, Barth M
J Pediatr Surg 2021 Dec;56(12):2364-2371. Epub 2021 Feb 11 doi: 10.1016/j.jpedsurg.2021.02.004. PMID: 33676744
Spinazzi EF, Desai SV, Fang CH, Jyung RW, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Nov;125(11):2593-600. Epub 2015 Apr 17 doi: 10.1002/lary.25308. PMID: 25892586
Jindal A, Bal A, Agarwal R
J Bronchology Interv Pulmonol 2015 Jan;22(1):58-65. doi: 10.1097/LBR.0000000000000105. PMID: 25590486
Desai SV, Spinazzi EF, Fang CH, Huang G, Tomovic S, Liu JK, Baredes S, Eloy JA
Laryngoscope 2015 Apr;125(4):813-21. Epub 2014 Nov 6 doi: 10.1002/lary.24993. PMID: 25376630

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