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Retinal astrocytic hamartoma

MedGen UID:: 137924
•Concept ID:: C0339554
•: Neoplastic Process

Synonym:	Retinal astrocytoma
SNOMED CT:	Retinal astrocytoma (255026000); Intraocular optic nerve glioma (416351002); Intraocular glioma (416351002); Astrocytoma of retina (255026000)

HPO:	HP:0012778

Definition

A glial tumor of the retinal nerve fiber layer arising from a retinal astrocyte. [from HPO]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVRetinal astrocytic hamartoma

Abnormality of the nervous system
- Abnormal nervous system morphology
  - Abnormal glial cell morphology
    - Abnormal astrocyte morphology
      - Astrocytoma
        Optic tract astrocytoma
        Retinal astrocytic hamartoma

Professional guidelines

PubMed

Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study.

Ryu S, Kang HC, Lee SC, Byeon SH, Kim SS, Lee CS
Yonsei Med J 2023 Feb;64(2):133-138. doi: 10.3349/ymj.2022.0451. PMID: 36719021 Free PMC Article

Treatment of Aggressive Retinal Astrocytic Hamartoma with Oral Mechanistic Target of Rapamycin Inhibition.

Wu F, McGarrey MP, Geenen KR, Skalet AH, Guillot FH, Wilson JL, Shah AS, Gonzalez E, Thiele EA, Kim IK, Aronow ME
Ophthalmol Retina 2022 May;6(5):411-420. Epub 2022 Jan 8 doi: 10.1016/j.oret.2022.01.003. PMID: 35007768

See all (2)

Recent clinical studies

Etiology

Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study.

Ryu S, Kang HC, Lee SC, Byeon SH, Kim SS, Lee CS
Yonsei Med J 2023 Feb;64(2):133-138. doi: 10.3349/ymj.2022.0451. PMID: 36719021 Free PMC Article

Ocular findings in pediatric turner syndrome.

Huang J, Basith SST, Patel S, Goetsch Weisman A, Brickman W, Mets MB, Mets-Halgrimson R
Ophthalmic Genet 2022 Aug;43(4):450-453. Epub 2022 Apr 5 doi: 10.1080/13816810.2022.2045512. PMID: 35382690

Treatment of Aggressive Retinal Astrocytic Hamartoma with Oral Mechanistic Target of Rapamycin Inhibition.

Optic coherence tomography appearances of retinal astrocytic hamartoma and systemic features in tuberous sclerosis of Japanese patients.

Kato A, Obana A, Gohto Y, Seto T, Sasano H
Eur J Ophthalmol 2019 May;29(3):330-337. Epub 2018 Jul 11 doi: 10.1177/1120672118787441. PMID: 29991284

RETINAL ASTROCYTIC HAMARTOMA: Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex.

Pichi F, Massaro D, Serafino M, Carrai P, Giuliari GP, Shields CL, Veronese C, Ciardella AP, Nucci P
Retina 2016 Jun;36(6):1199-208. doi: 10.1097/IAE.0000000000000829. PMID: 26618803

See all (18)

Diagnosis

Treatment of Aggressive Retinal Astrocytic Hamartoma with Oral Mechanistic Target of Rapamycin Inhibition.

Isolated retinal astrocytic hamartoma.

Bennett LW
Clin Exp Optom 2020 May;103(3):382-383. Epub 2019 Aug 23 doi: 10.1111/cxo.12956. PMID: 31441104

Clinical Features and Multi-Modality Imaging of Isolated Retinal Astrocytic Hamartoma.

Stacey AW, Pefkianaki M, Ilginis T, Michaelides M, Hykin P, Webster A, Moore AT, Sagoo MS
Ophthalmic Surg Lasers Imaging Retina 2019 Feb 1;50(2):e1-e9. doi: 10.3928/23258160-20190129-12. PMID: 30768223

RETINAL ASTROCYTIC HAMARTOMA: Optical Coherence Tomography Classification and Correlation With Tuberous Sclerosis Complex.

Pichi F, Massaro D, Serafino M, Carrai P, Giuliari GP, Shields CL, Veronese C, Ciardella AP, Nucci P
Retina 2016 Jun;36(6):1199-208. doi: 10.1097/IAE.0000000000000829. PMID: 26618803

Retinal astrocytic hamartoma.

Martin K, Rossi V, Ferrucci S, Pian D
Optometry 2010 May;81(5):221-33. doi: 10.1016/j.optm.2009.12.009. PMID: 20435268

See all (46)

Therapy

Treatment of Aggressive Retinal Astrocytic Hamartoma with Oral Mechanistic Target of Rapamycin Inhibition.

Everolimus to treat aggressive retinal astrocytic hamartoma in tuberous sclerosis complex.

Nallasamy N, Seider MI, Gururangan S, Mruthyunjaya P
J AAPOS 2017 Aug;21(4):328-331. Epub 2017 Jul 18 doi: 10.1016/j.jaapos.2017.04.012. PMID: 28733147

Sirolimus for Retinal Astrocytic Hamartoma Associated with Tuberous Sclerosis Complex.

Zhang ZQ, Shen C, Long Q, Yang ZK, Dai RP, Wang J, Zhang W, Pan Q, Zhu Z, Xu KF
Ophthalmology 2015 Sep;122(9):1947-9. Epub 2015 Apr 24 doi: 10.1016/j.ophtha.2015.03.023. PMID: 25912145

Bilateral cystoid macular edema with giant retinal achromic patch in a patient with tuberous sclerosis.

Andrews L, Lally DR, Baumal CR
Ophthalmic Surg Lasers Imaging Retina 2014 Nov-Dec;45(6):602-5. doi: 10.3928/23258160-20141118-19. PMID: 25423644

Intravitreal ranibizumab for choroidal neovascularization associated with retinal astrocytic hamartoma.

Querques G, Kerrate H, Leveziel N, Coscas G, Soubrane G, Souied EH
Eur J Ophthalmol 2010 Jul-Aug;20(4):789-91. doi: 10.1177/112067211002000424. PMID: 20213614

See all (6)

Prognosis

Isolated retinal astrocytic hamartoma with 7-year follow-up: A case report.

Wójcik-Niklewska B, Sirek S, Tronina A, Filipek E
Medicine (Baltimore) 2023 Sep 1;102(35):e34522. doi: 10.1097/MD.0000000000034522. PMID: 37657027 Free PMC Article

Treatment of Aggressive Retinal Astrocytic Hamartoma with Oral Mechanistic Target of Rapamycin Inhibition.

TWO-YEAR FOLLOW-UP OF A RETINAL ASTROCYTIC HAMARTOMA IMAGED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Amoroso F, Souied EH, Bruyère E, Astroz P, Mouallem-Beziere A, Pedinielli A, Miere A
Retin Cases Brief Rep 2022 May 1;16(3):338-343. Epub 2020 Jan 29 doi: 10.1097/ICB.0000000000000975. PMID: 32004181

Long-term follow-up of adult patient with neurofibromatosis type 1 with retinal astrocytic hamartoma using spectral-domain optical coherence tomography: a review of the literature and a report of a case.

Abdolrahimzadeh S, Formisano M, Scuderi L, Rahimi S
Ophthalmic Genet 2021 Apr;42(2):209-215. Epub 2020 Nov 17 doi: 10.1080/13816810.2020.1849315. PMID: 33203322

Clinical features and optical coherence tomography findings of retinal astrocytic hamartomas in Chinese patients with tuberous sclerosis complex.

Zhang C, Xu K, Long Q, Yang Z, Dai R, Du H, Li D, Zhang Z
Graefes Arch Clin Exp Ophthalmol 2020 Apr;258(4):887-892. Epub 2020 Jan 2 doi: 10.1007/s00417-019-04476-y. PMID: 31897702

See all (9)

Clinical prediction guides

Refractive Errors, Retinal Findings, and Genotype of Tuberous Sclerosis Complex: A Retrospective Cohort Study.

Ryu S, Kang HC, Lee SC, Byeon SH, Kim SS, Lee CS
Yonsei Med J 2023 Feb;64(2):133-138. doi: 10.3349/ymj.2022.0451. PMID: 36719021 Free PMC Article

Wide-field Fundus Imaging and Fluorescein Angiography Findings in Various Pseudoretinoblastoma Conditions.

Gündüz AK, Mirzayev I, Tetik D
J Pediatr Ophthalmol Strabismus 2023 Jan-Feb;60(1):60-74. Epub 2022 Apr 21 doi: 10.3928/01913913-20220228-01. PMID: 35446191

Vitreous haemorrhage a rare manifestation of retinal astrocytic hamartoma: a paediatric case report.

Salazar-Quiñones L, Arcos-Villegas G, Valverde-Megías A, Flores-Moreno I, Méndez-Fernández R, Díaz-Valle D
Arch Soc Esp Oftalmol (Engl Ed) 2019 Sep;94(9):449-452. Epub 2019 Jun 12 doi: 10.1016/j.oftal.2019.04.012. PMID: 31202691

Optic coherence tomography appearances of retinal astrocytic hamartoma and systemic features in tuberous sclerosis of Japanese patients.

Kato A, Obana A, Gohto Y, Seto T, Sasano H
Eur J Ophthalmol 2019 May;29(3):330-337. Epub 2018 Jul 11 doi: 10.1177/1120672118787441. PMID: 29991284

Optical coherence tomography of retinal astrocytic hamartoma in 15 cases.

Shields CL, Benevides R, Materin MA, Shields JA
Ophthalmology 2006 Sep;113(9):1553-7. doi: 10.1016/j.ophtha.2006.03.032. PMID: 16949441

See all (14)

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Retinal astrocytic hamartoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

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Table of contents

Clinical resources

Practice guidelines

Consumer resources

Reviews

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