U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive

MedGen UID:
1381788
•Concept ID:
C4329626
•
Neoplastic Process
Synonym: Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive

Definition

An anaplastic large cell lymphoma, ALK-positive, arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Anaplastic Large Cell Lymphoma, ALK-Positive

Professional guidelines

PubMed

Cost‑Effectiveness of Lorlatinib in First-Line Treatment of Adult Patients with Anaplastic Lymphoma Kinase (ALK)‑Positive Non‑Small‑Cell Lung Cancer in Sweden.
Naik J, Beavers N, Nilsson FOL, Iadeluca L, Lowry C
Appl Health Econ Health Policy 2023 Jul;21(4):661-672. Epub 2023 May 12 doi: 10.1007/s40258-023-00807-7. PMID: 37173513Free PMC Article
Optimizing treatment for patients with anaplastic lymphoma kinase-positive lung cancer.
Dagogo-Jack I, Shaw AT, Riely GJ
Clin Pharmacol Ther 2017 May;101(5):625-633. Epub 2017 Mar 17 doi: 10.1002/cpt.653. PMID: 28182271

Recent clinical studies

Etiology

Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK Positive.
Ahrendsen JT, Ta R, Li J, Weinberg OK, Ferry JA, Hasserjian RP, Meredith DM, Varma H, Sadigh S, Michaels PD
Am J Clin Pathol 2022 Aug 4;158(2):300-310. doi: 10.1093/ajcp/aqac046. PMID: 35460414
Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration.
Pearson ADJ, Barry E, Mossé YP, Ligas F, Bird N, de Rojas T, Zimmerman ZF, Wilner K, Woessmann W, Weiner S, Weigel B, Venkatramani R, Valteau D, Trahair T, Smith M, Singh S, Selvaggi G, Scobie N, Schleiermacher G, Richardson N, Park J, Nysom K, Norga K, Merino M, McDonough J, Matloub Y, Marshall LV, Lowe E, Lesa G, Irwin M, Karres D, Gajjar A, Doz F, Fox E, DuBois SG, Donoghue M, Casanova M, Caron H, Buenger V, Bradford D, Blanc P, Barone A, Reaman G, Vassal G
Eur J Cancer 2021 Nov;157:198-213. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.022. PMID: 34536944
Update on Pediatric and Young Adult Mature Lymphomas.
Mason EF, Kovach AE
Clin Lab Med 2021 Sep;41(3):359-387. Epub 2021 Jul 1 doi: 10.1016/j.cll.2021.03.018. PMID: 34304770
Primary and secondary central nervous system mature T- and NK-cell lymphomas.
Pang Y, Chihara D
Semin Hematol 2021 Apr;58(2):123-129. Epub 2021 Mar 3 doi: 10.1053/j.seminhematol.2021.02.003. PMID: 33906722
Prognostic factors in paediatric anaplastic large cell lymphoma: role of ALK.
Damm-Welk C, Pillon M, Woessmann W, Mussolin L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):205-16. doi: 10.2741/S434. PMID: 25961696

Diagnosis

Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK Positive.
Ahrendsen JT, Ta R, Li J, Weinberg OK, Ferry JA, Hasserjian RP, Meredith DM, Varma H, Sadigh S, Michaels PD
Am J Clin Pathol 2022 Aug 4;158(2):300-310. doi: 10.1093/ajcp/aqac046. PMID: 35460414
Update on Pediatric and Young Adult Mature Lymphomas.
Mason EF, Kovach AE
Clin Lab Med 2021 Sep;41(3):359-387. Epub 2021 Jul 1 doi: 10.1016/j.cll.2021.03.018. PMID: 34304770
Primary central nervous system ALK-positive anaplastic large cell lymphoma with CD56 abnormally expression in a Chinese child: Challenge in diagnostic practice.
Liu Q, Chen X, Li G, Ye Y, Liu W, Zhao S, Zhang W
Int J Immunopathol Pharmacol 2020 Jan-Dec;34:2058738420941756. doi: 10.1177/2058738420941756. PMID: 32664812Free PMC Article
Primary central nervous system ALK-positive anaplastic large cell lymphoma in an adult: A rare case report.
Dong X, Li J, Huo N, Wang Y, Wu Z, Lin X, Zhao H
Medicine (Baltimore) 2016 Dec;95(49):e5534. doi: 10.1097/MD.0000000000005534. PMID: 27930548Free PMC Article
Prognostic factors in paediatric anaplastic large cell lymphoma: role of ALK.
Damm-Welk C, Pillon M, Woessmann W, Mussolin L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):205-16. doi: 10.2741/S434. PMID: 25961696

Therapy

Long-term remission of primary refractory ALK-positive anaplastic large cell lymphoma after allogeneic hematopoietic stem cell transplantation.
Miyazaki M, Ichikawa S, Onishi Y, Fukuhara N, Furukawa E, Onodera K, Yokoyama H, Ichinohasama R, Harigae H
J Clin Exp Hematop 2022 Sep 28;62(3):164-168. Epub 2022 Jun 22 doi: 10.3960/jslrt.22003. PMID: 35732409Free PMC Article
Profound and sustained response with next-generation ALK inhibitors in patients with relapsed or progressive ALK-positive anaplastic large cell lymphoma with central nervous system involvement.
Rigaud C, Abbou S, Ducassou S, Simonin M, Le Mouel L, Pereira V, Gourdon S, Lambilliotte A, Geoerger B, Minard-Colin V, Brugieres L
Haematologica 2022 Sep 1;107(9):2255-2260. doi: 10.3324/haematol.2021.280081. PMID: 35586965Free PMC Article
Second Paediatric Strategy Forum for anaplastic lymphoma kinase (ALK) inhibition in paediatric malignancies: ACCELERATE in collaboration with the European Medicines Agency with the participation of the Food and Drug Administration.
Pearson ADJ, Barry E, Mossé YP, Ligas F, Bird N, de Rojas T, Zimmerman ZF, Wilner K, Woessmann W, Weiner S, Weigel B, Venkatramani R, Valteau D, Trahair T, Smith M, Singh S, Selvaggi G, Scobie N, Schleiermacher G, Richardson N, Park J, Nysom K, Norga K, Merino M, McDonough J, Matloub Y, Marshall LV, Lowe E, Lesa G, Irwin M, Karres D, Gajjar A, Doz F, Fox E, DuBois SG, Donoghue M, Casanova M, Caron H, Buenger V, Bradford D, Blanc P, Barone A, Reaman G, Vassal G
Eur J Cancer 2021 Nov;157:198-213. Epub 2021 Sep 15 doi: 10.1016/j.ejca.2021.08.022. PMID: 34536944
Optimizing treatment for patients with anaplastic lymphoma kinase-positive lung cancer.
Dagogo-Jack I, Shaw AT, Riely GJ
Clin Pharmacol Ther 2017 May;101(5):625-633. Epub 2017 Mar 17 doi: 10.1002/cpt.653. PMID: 28182271
Primary central nervous system ALK positive anaplastic large cell lymphoma with predominantly leptomeningeal involvement in an adult.
Park JS, Park H, Park S, Kim SJ, Seol HJ, Ko YH
Yonsei Med J 2013 May 1;54(3):791-6. doi: 10.3349/ymj.2013.54.3.791. PMID: 23549832Free PMC Article

Prognosis

Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK Positive.
Ahrendsen JT, Ta R, Li J, Weinberg OK, Ferry JA, Hasserjian RP, Meredith DM, Varma H, Sadigh S, Michaels PD
Am J Clin Pathol 2022 Aug 4;158(2):300-310. doi: 10.1093/ajcp/aqac046. PMID: 35460414
Primary and secondary central nervous system mature T- and NK-cell lymphomas.
Pang Y, Chihara D
Semin Hematol 2021 Apr;58(2):123-129. Epub 2021 Mar 3 doi: 10.1053/j.seminhematol.2021.02.003. PMID: 33906722
Optimizing treatment for patients with anaplastic lymphoma kinase-positive lung cancer.
Dagogo-Jack I, Shaw AT, Riely GJ
Clin Pharmacol Ther 2017 May;101(5):625-633. Epub 2017 Mar 17 doi: 10.1002/cpt.653. PMID: 28182271
Prognostic factors in paediatric anaplastic large cell lymphoma: role of ALK.
Damm-Welk C, Pillon M, Woessmann W, Mussolin L
Front Biosci (Schol Ed) 2015 Jun 1;7(2):205-16. doi: 10.2741/S434. PMID: 25961696
Primary anaplastic large cell lymphoma of the central nervous system: prognostic effect of ALK-1 expression.
George DH, Scheithauer BW, Aker FV, Kurtin PJ, Burger PC, Cameselle-Teijeiro J, McLendon RE, Parisi JE, Paulus W, Roggendorf W, Sotelo C
Am J Surg Pathol 2003 Apr;27(4):487-93. doi: 10.1097/00000478-200304000-00008. PMID: 12657933

Clinical prediction guides

Primary Central Nervous System Anaplastic Large Cell Lymphoma, ALK Positive.
Ahrendsen JT, Ta R, Li J, Weinberg OK, Ferry JA, Hasserjian RP, Meredith DM, Varma H, Sadigh S, Michaels PD
Am J Clin Pathol 2022 Aug 4;158(2):300-310. doi: 10.1093/ajcp/aqac046. PMID: 35460414
CNS progression during vinblastine or targeted therapies for high-risk relapsed ALK-positive anaplastic large cell lymphoma: A case series.
Ruf S, Hebart H, Hjalgrim LL, Kabickova E, Lang P, Steinbach D, Schwabe GC, Woessmann W
Pediatr Blood Cancer 2018 Jun;65(6):e27003. Epub 2018 Mar 7 doi: 10.1002/pbc.27003. PMID: 29512859
Primary central nervous system ALK-positive anaplastic large cell lymphoma in an adult: A rare case report.
Dong X, Li J, Huo N, Wang Y, Wu Z, Lin X, Zhao H
Medicine (Baltimore) 2016 Dec;95(49):e5534. doi: 10.1097/MD.0000000000005534. PMID: 27930548Free PMC Article
Primary CNS T-cell Lymphomas: A Clinical, Morphologic, Immunophenotypic, and Molecular Analysis.
Menon MP, Nicolae A, Meeker H, Raffeld M, Xi L, Jegalian AG, Miller DC, Pittaluga S, Jaffe ES
Am J Surg Pathol 2015 Dec;39(12):1719-1729. doi: 10.1097/PAS.0000000000000503. PMID: 26379152Free PMC Article
Primary anaplastic large cell lymphoma in the dura of the brain: case report and prediction of a favorable prognosis.
Kim MK, Cho CH, Sung WJ, Ryoo HM, Lee HJ, Youn SW, Park KK
Int J Clin Exp Pathol 2013;6(8):1643-51. Epub 2013 Jul 15 PMID: 23923083Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...