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Head and Neck Basaloid Carcinoma

MedGen UID:
234337
•Concept ID:
C1333940
•
Neoplastic Process
Synonyms: Basaloid Squamous Cell Carcinoma of Head and Neck; Basaloid Squamous Cell Carcinoma of the Head and Neck; Head and Neck Basaloid Squamous Cell Carcinoma

Definition

A high-grade, aggressive variant of squamous cell carcinoma that arises from the head and neck region. The most common sites of origin are pyriform sinus, epiglottis, and base of tongue. It is characterized by the presence of small malignant cells with hyperchromatic nuclei and scant amount of cytoplasm forming lobules with peripheral palisading. Comedonecrosis may be present. [from NCI]

Professional guidelines

PubMed

How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?
López F, Williams MD, Cardesa A, Hunt JL, Strojan P, Rinaldo A, Nixon IJ, Rodrigo JP, Saba NF, Mendenhall WM, Quer M, Suárez C, Ferlito A
Eur Arch Otorhinolaryngol 2017 Jul;274(7):2709-2726. Epub 2017 Mar 31 doi: 10.1007/s00405-017-4533-8. PMID: 28364287
Role of cytology in the diagnosis and management of HPV-associated head and neck carcinoma.
Krane JF
Acta Cytol 2013;57(2):117-26. Epub 2013 Feb 28 doi: 10.1159/000346715. PMID: 23406782
Basaloid squamous cell carcinoma of the head and neck: role of HPV and implication in treatment and prognosis.
Thariat J, Badoual C, Faure C, Butori C, Marcy PY, Righini CA
J Clin Pathol 2010 Oct;63(10):857-66. doi: 10.1136/jcp.2010.078154. PMID: 20876315

Recent clinical studies

Etiology

Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
HPV-related squamous cell carcinoma of oropharynx: a review.
Rahimi S
J Clin Pathol 2020 Oct;73(10):624-629. Epub 2020 Jun 4 doi: 10.1136/jclinpath-2020-206686. PMID: 32499224
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Diagnosis

Basaloid squamous cell carcinoma clinically and radiologically masquerading as a head and neck paraganglioma: a case report and review of the literature.
Weerasekara P, Chandrarathne N, Jayaweera G, Rathnayake W, Perera S
J Med Case Rep 2024 Jun 11;18(1):275. doi: 10.1186/s13256-024-04601-4. PMID: 38858796Free PMC Article
Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Diagnostic traps awaiting the head/neck pathologist: "Cytoplasm-poor" neoplasms.
Wakely PE Jr
Ann Diagn Pathol 2019 Oct;42:78-86. Epub 2019 Jul 27 doi: 10.1016/j.anndiagpath.2019.07.005. PMID: 31382078
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342

Therapy

Cetuximab and paclitaxel combination therapy for recurrent basaloid squamous cell carcinoma in the ethmoid sinus.
Koyama S, Fujiwara K, Morisaki T, Fujii T, Nakamura Y, Fukuhara T, Takeuchi H
Auris Nasus Larynx 2021 Dec;48(6):1189-1192. Epub 2020 Jul 16 doi: 10.1016/j.anl.2020.07.002. PMID: 32684403
Systemic therapy in non-conventional cancers of the larynx.
Tan E, Mody MD, Saba NF
Oral Oncol 2018 Jul;82:61-68. Epub 2018 May 26 doi: 10.1016/j.oraloncology.2018.05.005. PMID: 29909903
New insights into human papillomavirus-associated head and neck squamous cell carcinoma.
Boscolo-Rizzo P, Del Mistro A, Bussu F, Lupato V, Baboci L, Almadori G, DA Mosto MC, Paludetti G
Acta Otorhinolaryngol Ital 2013 Apr;33(2):77-87. PMID: 23853396Free PMC Article
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117
Different risk factors in basaloid and common squamous head and neck cancer.
Kleist B, Bankau A, Lorenz G, Jäger B, Poetsch M
Laryngoscope 2004 Jun;114(6):1063-8. doi: 10.1097/00005537-200406000-00020. PMID: 15179214

Prognosis

Top 10 Basaloid Neoplasms of the Sinonasal Tract.
Baněčková M, Cox D
Head Neck Pathol 2023 Mar;17(1):16-32. Epub 2023 Mar 16 doi: 10.1007/s12105-022-01508-8. PMID: 36928732Free PMC Article
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA
Am J Surg Pathol 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. PMID: 34049316
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
Carcinoma of the head and neck in the HPV era.
Cardesa A, Nadal A
Acta Dermatovenerol Alp Pannonica Adriat 2011 Sep;20(3):161-73. PMID: 22131117

Clinical prediction guides

The histological spectrum and immunoprofile of head and neck NUT carcinoma: A multicentre series of 30 cases.
Viswanathan K, Hahn E, Dogan S, Weinreb I, Dickson BC, MacMillan C, Katabi N, Magliocca K, Ghossein R, Xu B
Histopathology 2024 Aug;85(2):317-326. Epub 2024 May 6 doi: 10.1111/his.15204. PMID: 38708903Free PMC Article
Oral epithelial dysplasia: Recognition, grading and clinical significance.
Odell E, Kujan O, Warnakulasuriya S, Sloan P
Oral Dis 2021 Nov;27(8):1947-1976. Epub 2021 Sep 14 doi: 10.1111/odi.13993. PMID: 34418233
Clinicopathologic features and outcome of head and neck mucosal spindle cell squamous cell carcinoma.
Prieto-Granada CN, Xu B, Alzumaili B, Al Rasheed MRH, Eskander A, Enepekides D, Patel SG, Stevens TM, Dogan S, Ghossein R, Katabi N
Virchows Arch 2021 Oct;479(4):729-739. Epub 2021 May 12 doi: 10.1007/s00428-021-03117-2. PMID: 33982148Free PMC Article
Human papillomavirus-related head and neck squamous cell carcinoma variants.
El-Mofty SK
Semin Diagn Pathol 2015 Jan;32(1):23-31. Epub 2015 Feb 25 doi: 10.1053/j.semdp.2015.02.022. PMID: 25804342
The role of cytology in the era of HPV-related head and neck carcinoma.
Roy-Chowdhuri S, Krishnamurthy S
Semin Diagn Pathol 2015 Jul;32(4):250-7. Epub 2014 Dec 19 doi: 10.1053/j.semdp.2014.12.006. PMID: 25638437

Recent systematic reviews

Effectiveness of Nasolacrimal SCC Treatments and Promising Role of Chemo-Induction: A Case Report and Systematic Review.
Alsavaf MB, Abouammo MD, Bhuskute GS, Sun S, Issa M, Seim NB, VanKoevering KK, Bhateja P, Bonomi M, Carrau RL
Laryngoscope 2024 Sep;134(9):3892-3902. Epub 2024 Apr 23 doi: 10.1002/lary.31426. PMID: 38651346
Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma-An Even Broader Tumor Entity?
Zupancic M, Näsman A
Viruses 2021 Sep 17;13(9) doi: 10.3390/v13091861. PMID: 34578442Free PMC Article
Basaloid squamous cell carcinoma of the larynx--A systematic review.
Thankappan K
Auris Nasus Larynx 2012 Aug;39(4):397-401. Epub 2011 Aug 24 doi: 10.1016/j.anl.2011.07.018. PMID: 21868181

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