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B-Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 21

MedGen UID:
1389629
•Concept ID:
C4329384
•
Neoplastic Process
Synonyms: B lymphoblastic leukemia lymphoma with iAMP21; B lymphoblastic leukemia lymphoma with intrachromosomal amplification of chromosome 21; B Lymphoblastic Leukemia/Lymphoma with iAMP21; B Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 21; B-Lymphoblastic Leukemia/Lymphoma with iAMP21
SNOMED CT: B lymphoblastic leukemia lymphoma with iAMP21 (785825000); B lymphoblastic leukemia lymphoma with intrachromosomal amplification of chromosome 21 (785825000)

Definition

B lymphoblastic leukemia/lymphoma characterized by amplification of a portion of chromosome 21. It usually occurs in children and is associated with an adverse prognosis. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVB-Lymphoblastic Leukemia/Lymphoma with Intrachromosomal Amplification of Chromosome 21

Recent clinical studies

Etiology

Clinicopathologic and genetic evaluation of B-lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 (iAMP21) in adult patients.
Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M
Leuk Lymphoma 2022 Dec;63(13):3200-3207. Epub 2022 Aug 22 doi: 10.1080/10428194.2022.2113524. PMID: 35995457
Characterization of unusual iAMP21 B-lymphoblastic leukemia (iAMP21-ALL) from the Mayo Clinic and Children's Oncology Group.
Koleilat A, Smadbeck JB, Zepeda-Mendoza CJ, Williamson CM, Pitel BA, Golden CL, Xu X, Greipp PT, Ketterling RP, Hoppman NL, Peterson JF, Harrison CJ, Akkari YMN, Tsuchiya KD, Shago M, Baughn LB
Genes Chromosomes Cancer 2022 Dec;61(12):710-719. Epub 2022 Jul 19 doi: 10.1002/gcc.23084. PMID: 35771717Free PMC Article
SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia.
Baughn LB, Meredith MM, Oseth L, Smolarek TA, Hirsch B
Cancer Genet 2018 Oct;226-227:30-35. Epub 2018 Jun 8 doi: 10.1016/j.cancergen.2018.05.004. PMID: 30005852
Cytogenetic Variation of B-Lymphoblastic Leukemia With Intrachromosomal Amplification of Chromosome 21 (iAMP21): A Multi-Institutional Series Review.
Johnson RC, Weinberg OK, Cascio MJ, Dahl GV, Mitton BA, Silverman LB, Cherry AM, Arber DA, Ohgami RS
Am J Clin Pathol 2015 Jul;144(1):103-12. doi: 10.1309/AJCPLUYF11HQBYRB. PMID: 26071468

Diagnosis

Clinicopathologic and genetic evaluation of B-lymphoblastic leukemia with intrachromosomal amplification of chromosome 21 (iAMP21) in adult patients.
Zak T, Gao J, Behdad A, Mehta J, Altman JK, Ji P, Lu X, Sukhanova M
Leuk Lymphoma 2022 Dec;63(13):3200-3207. Epub 2022 Aug 22 doi: 10.1080/10428194.2022.2113524. PMID: 35995457
SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia.
Baughn LB, Meredith MM, Oseth L, Smolarek TA, Hirsch B
Cancer Genet 2018 Oct;226-227:30-35. Epub 2018 Jun 8 doi: 10.1016/j.cancergen.2018.05.004. PMID: 30005852
Cytogenetic Variation of B-Lymphoblastic Leukemia With Intrachromosomal Amplification of Chromosome 21 (iAMP21): A Multi-Institutional Series Review.
Johnson RC, Weinberg OK, Cascio MJ, Dahl GV, Mitton BA, Silverman LB, Cherry AM, Arber DA, Ohgami RS
Am J Clin Pathol 2015 Jul;144(1):103-12. doi: 10.1309/AJCPLUYF11HQBYRB. PMID: 26071468

Prognosis

SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia.
Baughn LB, Meredith MM, Oseth L, Smolarek TA, Hirsch B
Cancer Genet 2018 Oct;226-227:30-35. Epub 2018 Jun 8 doi: 10.1016/j.cancergen.2018.05.004. PMID: 30005852

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