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Metastatic Malignant Neoplasm in the Thymus

MedGen UID:
146356
•Concept ID:
C0686617
•
Neoplastic Process
Synonyms: Metastasis to the Thymus; Metastasis to thymus; Metastatic malignant neoplasm of thymus; Metastatic Malignant Neoplasm to the Thymus; Metastatic malignant neoplasm to thymus; Metastatic Malignant Tumor to the Thymus; Metastatic Neoplasm to the Thymus; Metastatic Tumor to the Thymus; Secondary malignant neoplasm of thymus; Secondary Malignant Neoplasm to the Thymus; Secondary malignant tumor of thymus; Secondary Malignant Tumor to the Thymus
SNOMED CT: Secondary malignant neoplasm of thymus (94632009); Metastatic malignant neoplasm to thymus (94632009); Metastatic malignant neoplasm of thymus (94632009); Metastasis to thymus (94632009); Secondary malignant tumor of thymus (94632009)

Definition

A malignant neoplasm that has spread to the thymus from another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Malignant Neoplasm in the Thymus

Professional guidelines

PubMed

Pitfalls in Challenging Thyroid Tumors: Emphasis on Differential Diagnosis and Ancillary Biomarkers.
Cameselle-Teijeiro JM, Eloy C, Sobrinho-Simões M
Endocr Pathol 2020 Sep;31(3):197-217. Epub 2020 Jul 6 doi: 10.1007/s12022-020-09638-x. PMID: 32632840Free PMC Article
Thymic epithelial tumors: From biology to treatment.
Conforti F, Pala L, Giaccone G, De Pas T
Cancer Treat Rev 2020 Jun;86:102014. Epub 2020 Mar 23 doi: 10.1016/j.ctrv.2020.102014. PMID: 32272379
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Recent clinical studies

Etiology

Understanding the landscape of immunotherapy in thymic epithelial tumors.
Maniar R, Loehrer PJ Sr
Cancer 2023 Apr 15;129(8):1162-1172. Epub 2023 Feb 19 doi: 10.1002/cncr.34678. PMID: 36808725
Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA): a multicentre, phase 2 trial.
Sato J, Satouchi M, Itoh S, Okuma Y, Niho S, Mizugaki H, Murakami H, Fujisaka Y, Kozuki T, Nakamura K, Nagasaka Y, Kawasaki M, Yamada T, Machida R, Kuchiba A, Ohe Y, Yamamoto N
Lancet Oncol 2020 Jun;21(6):843-850. doi: 10.1016/S1470-2045(20)30162-5. PMID: 32502444

Diagnosis

Approach to Mediastinal Fine Needle Aspiration Cytology.
Li Z, Xu H, Fan F
Adv Anat Pathol 2022 Nov 1;29(6):337-348. Epub 2022 Jul 18 doi: 10.1097/PAP.0000000000000355. PMID: 35838636
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550
Cardiac tamponade.
Knoop T, Willenberg K
Semin Oncol Nurs 1999 Aug;15(3):168-73. doi: 10.1016/s0749-2081(99)80004-7. PMID: 10461701

Therapy

Understanding the landscape of immunotherapy in thymic epithelial tumors.
Maniar R, Loehrer PJ Sr
Cancer 2023 Apr 15;129(8):1162-1172. Epub 2023 Feb 19 doi: 10.1002/cncr.34678. PMID: 36808725
Immune checkpoint blockers in patients with unresectable or metastatic thymic epithelial tumours: A meta-analysis.
Remon J, Villacampa G, Facchinetti F, Di Maio M, Marcuse F, Tiseo M, Hochstenbag M, Hendriks LEL, Besse B
Eur J Cancer 2023 Feb;180:117-124. Epub 2022 Dec 12 doi: 10.1016/j.ejca.2022.12.005. PMID: 36592506
Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Lenvatinib in patients with advanced or metastatic thymic carcinoma (REMORA): a multicentre, phase 2 trial.
Sato J, Satouchi M, Itoh S, Okuma Y, Niho S, Mizugaki H, Murakami H, Fujisaka Y, Kozuki T, Nakamura K, Nagasaka Y, Kawasaki M, Yamada T, Machida R, Kuchiba A, Ohe Y, Yamamoto N
Lancet Oncol 2020 Jun;21(6):843-850. doi: 10.1016/S1470-2045(20)30162-5. PMID: 32502444
Thymoma: Diagnosis and treatment.
Singh G, Rumende CM, Amin Z
Acta Med Indones 2011 Jan;43(1):74-8. PMID: 21339550

Prognosis

Molecular profiling and target actionability for precision medicine in neuroendocrine neoplasms: real-world data.
Boilève A, Faron M, Fodil-Cherif S, Bayle A, Lamartina L, Planchard D, Tselikas L, Kanaan C, Scoazec JY, Ducreux M, Italiano A, Baudin E, Hadoux J
Eur J Cancer 2023 Jun;186:122-132. Epub 2023 Mar 24 doi: 10.1016/j.ejca.2023.03.024. PMID: 37062210
Conventional and radiomic features to predict pathology in the preoperative assessment of anterior mediastinal masses.
Mayoral M, Pagano AM, Araujo-Filho JAB, Zheng J, Perez-Johnston R, Tan KS, Gibbs P, Fernandes Shepherd A, Rimner A, Simone II CB, Riely G, Huang J, Ginsberg MS
Lung Cancer 2023 Apr;178:206-212. Epub 2023 Feb 21 doi: 10.1016/j.lungcan.2023.02.014. PMID: 36871345Free PMC Article
Overview of the 2022 WHO Classification of Thyroid Neoplasms.
Baloch ZW, Asa SL, Barletta JA, Ghossein RA, Juhlin CC, Jung CK, LiVolsi VA, Papotti MG, Sobrinho-Simões M, Tallini G, Mete O
Endocr Pathol 2022 Mar;33(1):27-63. Epub 2022 Mar 14 doi: 10.1007/s12022-022-09707-3. PMID: 35288841
Common and rare carcinomas of the thymus.
Roden AC, Szolkowska M
Virchows Arch 2021 Jan;478(1):111-128. Epub 2021 Jan 3 doi: 10.1007/s00428-020-03000-6. PMID: 33389148
The role of targeted therapy in thymic carcinoma.
Krishnan M, Ganti AK
J Oncol Pharm Pract 2019 Oct;25(7):1712-1718. Epub 2019 Jun 4 doi: 10.1177/1078155219852758. PMID: 31159657

Clinical prediction guides

Conventional and radiomic features to predict pathology in the preoperative assessment of anterior mediastinal masses.
Mayoral M, Pagano AM, Araujo-Filho JAB, Zheng J, Perez-Johnston R, Tan KS, Gibbs P, Fernandes Shepherd A, Rimner A, Simone II CB, Riely G, Huang J, Ginsberg MS
Lung Cancer 2023 Apr;178:206-212. Epub 2023 Feb 21 doi: 10.1016/j.lungcan.2023.02.014. PMID: 36871345Free PMC Article
Clinicogenomic Landscape of Metastatic Thymic Epithelial Tumors.
Ardeshir-Larijani F, Schneider BP, Althouse SK, Radovich M, Masood A, Perna F, Salman H, Loehrer PJ
JCO Precis Oncol 2023 Feb;7:e2200465. doi: 10.1200/PO.22.00465. PMID: 36787505Free PMC Article
Efficacy and Safety of Rituximab for New-Onset Generalized Myasthenia Gravis: The RINOMAX Randomized Clinical Trial.
Piehl F, Eriksson-Dufva A, Budzianowska A, Feresiadou A, Hansson W, Hietala MA, Håkansson I, Johansson R, Jons D, Kmezic I, Lindberg C, Lindh J, Lundin F, Nygren I, Punga AR, Press R, Samuelsson K, Sundström P, Wickberg O, Brauner S, Frisell T
JAMA Neurol 2022 Nov 1;79(11):1105-1112. doi: 10.1001/jamaneurol.2022.2887. PMID: 36121672Free PMC Article
Thymoma and thymic carcinoma.
Venuta F, Rendina EA, Anile M, de Giacomo T, Vitolo D, Coloni GF
Gen Thorac Cardiovasc Surg 2012 Jan;60(1):1-12. Epub 2012 Jan 13 doi: 10.1007/s11748-011-0814-0. PMID: 22237733
Cardiac tamponade.
Knoop T, Willenberg K
Semin Oncol Nurs 1999 Aug;15(3):168-73. doi: 10.1016/s0749-2081(99)80004-7. PMID: 10461701

Recent systematic reviews

Postoperative Radiotherapy for Completely Resected Masaoka/Masaoka-Koga Stage II/III Thymoma Improves Overall Survival: An Updated Meta-Analysis of 4746 Patients.
Tateishi Y, Horita N, Namkoong H, Enomoto T, Takeda A, Kaneko T
J Thorac Oncol 2021 Apr;16(4):677-685. Epub 2021 Jan 27 doi: 10.1016/j.jtho.2020.12.023. PMID: 33515812
Pathological and clinical features of enteric adenocarcinoma of the thymus. A pooled analysis of cases from a reference center and systematic review of the literature.
Conforti F, Tarantino P, Trillo P, Pala L, Zagami P, Pirola S, Di Venosa B, Catania C, Queirolo P, Pennacchioli E, Della Vigna P, Curigliano G, De Pas TM
Cancer Treat Rev 2021 Jan;92:102133. Epub 2020 Dec 3 doi: 10.1016/j.ctrv.2020.102133. PMID: 33296826
Adjuvant radiotherapy for thymic epithelial tumors: a systematic review and meta-analysis.
Korst RJ, Kansler AL, Christos PJ, Mandal S
Ann Thorac Surg 2009 May;87(5):1641-7. doi: 10.1016/j.athoracsur.2008.11.022. PMID: 19379938
Primary intrapulmonary thymoma: a systematic review.
Myers PO, Kritikos N, Bongiovanni M, Triponez F, Collaud S, Pache JC, Robert JH
Eur J Surg Oncol 2007 Dec;33(10):1137-41. Epub 2007 Apr 17 doi: 10.1016/j.ejso.2007.02.033. PMID: 17442530

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